1887

Abstract

Summary

Recombinant and parental poliovirus particles were indistinguishable by ratezonal and isopycnic sedimentation, and by u.v. inactivation. Sensitive selective procedures, applied to recombinants to detect genetic segregation of one parent, failed to reveal any. Poliovirus genetic recombinant particles thus appear to be conventional virus particles; their significance for recombination mechanisms is discussed. Sensitivity to the growth inhibitor 2-(3-chloro--tolyl)-5-ethyl-1,3,4-oxadiazole is shown to depend on a product of the structural protein gene.

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/content/journal/jgv/10.1099/0022-1317-23-1-41
1974-04-01
2019-10-15
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http://instance.metastore.ingenta.com/content/journal/jgv/10.1099/0022-1317-23-1-41
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