%0 Journal Article %A Cooper, P. D. %A Steiner-Pryor, A. %A Scotti, P. D. %A Delong, D. %T On the Nature of Poliovirus Genetic Recombinants %D 1974 %J Journal of General Virology, %V 23 %N 1 %P 41-49 %@ 1465-2099 %R https://doi.org/10.1099/0022-1317-23-1-41 %I Microbiology Society, %X SUMMARY Recombinant and parental poliovirus particles were indistinguishable by ratezonal and isopycnic sedimentation, and by u.v. inactivation. Sensitive selective procedures, applied to ts + recombinants to detect genetic segregation of one parent, failed to reveal any. Poliovirus genetic recombinant particles thus appear to be conventional virus particles; their significance for recombination mechanisms is discussed. Sensitivity to the growth inhibitor 2-(3-chloro-p-tolyl)-5-ethyl-1,3,4-oxadiazole is shown to depend on a product of the structural protein gene. %U https://www.microbiologyresearch.org/content/journal/jgv/10.1099/0022-1317-23-1-41