1887

Abstract

SUMMARY

Hybridization reactions between the DNAs of the six members of the ‘weakly’ oncogenic adenovirus group (types 3, 7, 11, 14, 16 and 21) show that they are closely related to each other, sharing 70 to 100 % of their nucleotide sequences. The ‘weakly’ oncogenic adenoviruses are but distantly related to ‘strongly’ oncogenic types 12 and 18, showing only 11 to 22% homology. Thus, two groups of oncogenic adenoviruses exist, differing remarkably in nucleotide sequence as well as in base composition and degree of oncogenicity.

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/content/journal/jgv/10.1099/0022-1317-1-4-413
1967-10-01
2022-08-10
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References

  1. Bolton E. T., Mccarthy B. J. 1963; An approach to the measurement of genetic relatedness among organisms. Proc. natn. Acad. Sci. U.S.A 50:156
    [Google Scholar]
  2. Girardi A. J., Hilleman M. R., Zwickey R. E. 1964; Tests in hamsters for oncogenic quality of ordinary viruses including adenovirus type 7. Proc. Soc. exp. Biol. Med 115:1141
    [Google Scholar]
  3. Green M., Piña M. 1964; Biochemical studies on adenovirus multiplication, VI. Properties of highly purified tumorigenic human adenoviruses and their DNAs. Proc. natn. Acad. Sci. U.S.A 51:1251
    [Google Scholar]
  4. Green M., Piña M., Kimes R., Wensink P. C., Machattie L. A., Thomas C. A. Jun 1967 Proc. natn. Acad. Sci. U.S.A 57:1302
    [Google Scholar]
  5. Hoyer B. H., Mccarthy B. J., Bolton E. T. 1964; A molecular approach in the systematics of higher organisms. Science, N. Y 144:959
    [Google Scholar]
  6. Huebner R. J., Rowe W. P., Lane W. T. 1962; Oncogenic effects in hamsters of human adenovirus types 12 and 18. Proc. natn. Acad. Sci. U.S.A 48:2051
    [Google Scholar]
  7. Huebner R. J., Casey M. J., Chanock R. M., Schell K. 1965; Tumors induced in hamsters by a strain of adenovirus type 3: sharing of tumor antigens and ‘neoantigens’ with those produced by adenovirus type 7 tumors. Proc. natn. Acad. Sci. U.S.A 54:381
    [Google Scholar]
  8. Huebner R. J., Rowe W. P., Turner H. C., Lane W. T. 1963; Specific adenovirus complement-fixing antigen in virus free hamster and rat tumors. Proc. natn. Acad. Sci. U.S.A 50:379
    [Google Scholar]
  9. Lacy S., Green M. 1964; Biochemical studies on adenovirus multiplication. VII. Homology between DNAs of tumorigenic and nontumorigenic human adenoviruses. Proc. natn. Acad. Sci. U.S.A 52:1053
    [Google Scholar]
  10. Lacy S., Green M. 1965; Adenovirus multiplication: Genetic relatedness of tumorigenic human adenovirus types 7, 12, and 18. Science, N. Y 150:1296
    [Google Scholar]
  11. Mccarthy B. J., Bolton E. T. 1962; A general method for the isolation of RNA complementary to DNA. Proc. natn. Acad. Sci. U.S.A 48:1390
    [Google Scholar]
  12. Mclaren A., Walker P. 1965; Genetic discrimination by means of DNA/DNA binding. Genet. Res 6:230
    [Google Scholar]
  13. Pereira H. G., Huebner R. J., Ginsberg H. S., Van der Veen J. 1963; A short description of the adenovirus group. Virology 20:613
    [Google Scholar]
  14. Pereira M. S., Pereira H. G., Clarke S. K. R. 1965; Human adenovirus type 31. A new serotype with oncogenic properties. Lancet 1:21
    [Google Scholar]
  15. Piña M., Green M. 1965; Biochemical studies on adenovirus multiplication. IX. Chemical and base composition analysis of 28 human adenovirus. Proc. natn. Acad. Sci. U.S.A 54:547
    [Google Scholar]
  16. Trentin J. J., Yabe Y., Taylor G. 1962; The quest for human cancer viruses. Science, N.Y 137:835
    [Google Scholar]
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