1887

Abstract

Summary

Two influenza A viruses, neurotropic and its recombinant are capable of forming plaques on BHK21 cells, plaques are larger than plaques. The small plaque size of virus is related to a slower rate of increase of than virus during many cycles of infection, not to inhibition by the non-cellular enviroent. The slow increase could be accounted for by a delay in the formation of infectious virus in each cycle accompanied by a simultaneous delay in release. The synthesis of virus is accompanied by a large quantity of unassembled or unstable noninfectious haemagglutinin; the synthesis of virus yields assembled infectious haemagglutinin predominantly.

Loading

Article metrics loading...

/content/journal/jgv/10.1099/0022-1317-1-2-189
1967-04-01
2022-01-18
Loading full text...

Full text loading...

/deliver/fulltext/jgv/1/2/JV0010020189.html?itemId=/content/journal/jgv/10.1099/0022-1317-1-2-189&mimeType=html&fmt=ahah

References

  1. Ada G. L., Stone J. D. 1950; Electrophoretic studies of virus red-cell interaction: mobility gradient of cells treated with viruses of the influenza group and the receptor destroying enzyme of V. cholerae . Br. J. exp. Path 31:263
    [Google Scholar]
  2. Burnet F. M. 1935; Influenza virus isolated from an Australian epidemic. Med. J. Austr 2:651
    [Google Scholar]
  3. Burnet F. M. 1936; The use of the developing egg in virus research. Spec. Rep. Ser. Med. Res. Com22025
    [Google Scholar]
  4. Burnet F. M., Edney M. 1951; Recombinant viruses obtained from double infections with the influenza A viruses Mel and Neuro-WS. Aust. J. exp. Biol. med. Sci 29:353
    [Google Scholar]
  5. Burnet F. M., Lind P. E. 1951; A genetic approach to variation in influenza viruses. 4. Recombination of characters between the influenza virus A strain NWS and strains of different serological sub types. J. gen. Microbiol 5:67
    [Google Scholar]
  6. Cairns H. J. F., Mason P. T. 1954; Production of influenza A virus in cells of the allantois. J. Immun 71:38
    [Google Scholar]
  7. Choppin P. 1962; Plaque formation by influenza A2 virus in monkey kidney cells. Virology 18:332
    [Google Scholar]
  8. Choppin P. W. 1963; Multiplication of two kinds of influenza A2 virus particles in monkey kidney cells. Virology 21:342
    [Google Scholar]
  9. Dulbecco R., Vogt M. 1954; Plaque formation and isolation of pure lines with poliomyelitis viruses. J. exp. Med 99:167
    [Google Scholar]
  10. Dukes G. R., Wenner H. A. 1957; Virulence of polioviruses in relation to variant characteristics distinguishable on cells in vitro . Virology 4:275
    [Google Scholar]
  11. Franklin R. M., Breitenfeld P. M. 1959; The abortive infection of Earle’s L-cells by fowl plague virus. Virology 8:293
    [Google Scholar]
  12. Fraser K. B. 1967; The comparative immunofluorescence of abortive and complete infections by influenza A strains in BHK21 cells and Earle’s L cells and its significance. in the Press
    [Google Scholar]
  13. Grosberg S. E. 1963; Cytocidal assay and propagation of human influenza viruses in cultured primary hamster kidney cells. Proc. Soc. exp. Biol. Med 113:546
    [Google Scholar]
  14. Hinz R. W., Syverton J. T. 1959; Mammalian cell cultures for study of influenza virus. II. Virus propagation. Proc. Soc. exp. Biol. Med 101:22
    [Google Scholar]
  15. Lehmann-Grube F. 1963; Influenza viruses in cell cultures. I. Preparation and use of foetal pig lung cells for quantal assay. Arch. ges. Virusforsch 14:1
    [Google Scholar]
  16. Macpherson I. A., Stoker M. G. P. 1962; Polyoma transformation of hamster cell clones-an investigation of genetic factors affecting cell competence. Virology 16:147
    [Google Scholar]
  17. von Magnus P. 1954; Incomplete forms of influenza virus. Adv. Virus Res 2:59
    [Google Scholar]
  18. Reed L. J., Muench H. 1938; A simple method of estimating fifty per cent endpoints. Am. J. Hyg 27:493
    [Google Scholar]
  19. Sugiura A., Kilbourne E. D. 1965; Genetic studies of influenza viruses. II. Plaque formation by influenza viruses in a clone of a variant human heteroploid cell line. Virology 26:478
    [Google Scholar]
  20. Stoker M. G. P., Macpherson I. A. 1964; Syrian hamster fibroblast cell line BHK21 and its derivatives. Nature; Land: 2031355
    [Google Scholar]
  21. Stuart-Harris C. H. 1939; A neurotropic strain of human influenza virus. Lancet 1:497
    [Google Scholar]
  22. Wong S. C., Kilbourne E. D. 1961; Changing viral susceptibility of a human cell line in continuous cultivation. I. Production of infective virus in a variant of the Chang conjunctival cell following infection with swine or N-WS influenza virus. J. exp. Med 113:95
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jgv/10.1099/0022-1317-1-2-189
Loading
/content/journal/jgv/10.1099/0022-1317-1-2-189
Loading

Data & Media loading...

Most cited this month Most Cited RSS feed

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error