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Volume 3, Issue 12

Spectrum of mycobacterial pathogens responsible for head and neck tuberculosis-like presentation Open Access

Abstract

Tuberculosis (TB) of the head and neck can be contained in the lymph nodes, larynx, oropharynx, salivary glands, nose and paranasal sinuses, ear, skin and skull. Head and neck TB presentations are varied in nature and thus difficult to diagnose. The clinical features, radiological findings, microbiological diagnostic modalities, surgical and medical management and outcomes of nine cases of head and neck TB are discussed in detail here, together with a thorough review of the literature. Patients presented with atypical symptoms such as discharging sinus, ear lobule swelling, otitis media, vision loss and facial weakness, long refractory otorrhoea and granulation tissue in the ear canal. We diagnosed tubercular skull base osteomyelitis (one case) and laryngeal tuberculosis (two cases), mastoid tuberculosis (one case) and non-tubercular mycobacterial infection involving the temporal bone (two cases), sino-nasal region (one case), maxilla (one cases) and ear lobule (one case) over a period of 8 months. All patients were managed successfully with a combination of surgery and a well-planned treatment regimen for non-tuberculous mycobacteria (NTM) or anti-tubercular drugs for TB. All had successful outcomes except one patient with tubercular skull base osteomyelitis who expired before the initiation of anti-tubercular therapy (ATT). High clinical suspicion followed by thorough diagnostic work-up for both TB and NTM would enable early diagnosis and complete treatment.

  • Received:
  • Accepted:
  • Published Online:
Keyword(s): laryngeal tuberculosis , maxillary tuberculosis , Mycobacterium tuberculosis , non-tuberculous mycobacteria and skull base osteomyelitis
© 2021 The Authors
  • This is an open-access article distributed under the terms of the Creative Commons Attribution License. The Microbiology Society waived the open access fees for this article.
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2021-12-17
2024-04-26
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Spectrum of mycobacterial pathogens responsible for head and neck tuberculosis-like presentation
Access Microbiology 3, 000304 (2021); https://doi.org/10.1099/acmi.0.000304
/content/journal/acmi/10.1099/acmi.0.000304
/content/journal/acmi/10.1099/acmi.0.000304
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