1887

Abstract

is an emerging fungal pathogen in blood The main aim of this study was to describe the prevalence, methods of speciation and antifungal susceptibility of at a tertiary care centre.

This was a retrospective study carried out at a tertiary care centre in South India. Over a period of 1 year, three were isolated from blood culture identified by MALDI–TOF MS Version 3.2 and were confirmed by ITS sequencing. Susceptibility testing was carried out by micro broth dilution.

All three patients had a common risk factor of prolonged ICU stay but the source of infection could not be identified. isolates were identified by MALDI–TOF and confirmed by ITS sequencing. They were pansusceptible to all tested antifungal drugs. Among these, two patients who were treated in hospital had good clinical outcome and response to antifungal drugs. A third patient was lost to follow up.

was predominantly seen between 0–3 month olds. Conventional methods of speciation were unable to identify to species level. Rapid identification was done by MALDI–TOF MS and confirmed by sequencing. Rapid identification leads to prompt treatment and favours a good clinical outcome.

Funding
This study was supported by the:
  • Christian Medical College, Vellore (Award IRB Min No 13343)
    • Principle Award Recipient: SreelekshmiTS
  • This is an open-access article distributed under the terms of the Creative Commons Attribution NonCommercial License. The Microbiology Society waived the open access fees for this article.
Loading

Article metrics loading...

/content/journal/acmi/10.1099/acmi.0.000281
2021-10-11
2021-10-24
Loading full text...

Full text loading...

/deliver/fulltext/acmi/3/10/acmi000281.html?itemId=/content/journal/acmi/10.1099/acmi.0.000281&mimeType=html&fmt=ahah

References

  1. Delaloye J, Calandra T. Invasive candidiasis as a cause of sepsis in the critically ill patient. Virulence 2014; 5:161–169 [View Article]
    [Google Scholar]
  2. Free online library Prevalence of non-albicans candidemia in a tertiary care hospital in northeast India. https://www.thefreelibrary.com accessed 04 Sep 2021
  3. Agarwal V, Tomer P, Gupta P, Upadhyay A. Epidemiology, clinical spectrum and outcomes of fungal sepsis in neonates in neonatal intensive care unit:a prospective observational stuClinical Spectrum and Outcomes of Fungal Sepsis in Neonates in Neonatal Intensive Care Unit:A Prospective Observational Study. Biomed Res Int 2018; 5:5
    [Google Scholar]
  4. Lukić-Grlić A, Mlinarić-Missoni E, Škarić I, Važić-Babić V, Svetec I-K. Candida utilis candidaemia in neonatal patients. J Med Microbiol 2011; 60:838–841 [View Article]
    [Google Scholar]
  5. Idelevich EA, Grünastel B, Becker K. Rapid detection and identification of Candidemia by direct blood culturing on solid medium by use of lysis-centrifugation method combined with Matrix-Assisted Laser Desorption Ionization–Time of Flight Mass Spectrometry (MALDI-TOF MS). J Clin Microbiol 2017; 55:97–100
    [Google Scholar]
  6. Wickes BL, Wiederhold NP. Molecular diagnostics in medical mycology. Nat Commun 2018; Dec;9(1):5135:
    [Google Scholar]
  7. Neonatal Sepsis - Pediatrics [Internet] MSD manual professional edition. https://www.msdmanuals.com/professional/pediatrics/infections-in-neonates/neonatal-sepsis accessed 17 Jun 2017
  8. Shivadasan J, Raksha K, Urs P. Candida utilis causing neonatal Candidemia – A case report and literature review. Apollo Medicine 2016; 13: [View Article]
    [Google Scholar]
  9. Treguier P, David M, Gargala G, Camus V, Stamatoullas A et al. Cyberlindnera jadinii (teleomorph Candida utilis) candidaemia in a patient with aplastic anaemia: a case report. JMM Case Rep 2018; 5:e005160 [View Article]
    [Google Scholar]
  10. Scoppettuolo G, Donato C, De Carolis E, Vella A, Vaccaro L et al. Candida utilis catheter-related bloodstream infection. Med Mycol Case Rep 2014; 6:70–72
    [Google Scholar]
  11. Bougnoux ME, Gueho E, Potocka AC. Resolutive Candida utilis fungemia in a nonneutropenic patient. J Clin Microbiol 1993311644–1645 [View Article] [PubMed]
    [Google Scholar]
  12. Alsina A, Mason M, Uphoff RA, Riggsby WS, Becker JM et al. Catheter-associated Candida utilis fungemia in a patient with acquired immunodeficiency syndrome: species verification with a molecular probe. J Clin Microbiol 1988; 26:621–624
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/acmi/10.1099/acmi.0.000281
Loading
/content/journal/acmi/10.1099/acmi.0.000281
Loading

Data & Media loading...

Most cited this month Most Cited RSS feed

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error