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Volume 3, Issue 10

rare cause of septicemia in children Open Access

Abstract

is an emerging fungal pathogen in blood The main aim of this study was to describe the prevalence, methods of speciation and antifungal susceptibility of at a tertiary care centre.

This was a retrospective study carried out at a tertiary care centre in South India. Over a period of 1 year, three were isolated from blood culture identified by MALDI–TOF MS Version 3.2 and were confirmed by ITS sequencing. Susceptibility testing was carried out by micro broth dilution.

All three patients had a common risk factor of prolonged ICU stay but the source of infection could not be identified. isolates were identified by MALDI–TOF and confirmed by ITS sequencing. They were pansusceptible to all tested antifungal drugs. Among these, two patients who were treated in hospital had good clinical outcome and response to antifungal drugs. A third patient was lost to follow up.

was predominantly seen between 0–3 month olds. Conventional methods of speciation were unable to identify to species level. Rapid identification was done by MALDI–TOF MS and confirmed by sequencing. Rapid identification leads to prompt treatment and favours a good clinical outcome.

  • Received:
  • Accepted:
  • Published Online:
Keyword(s): Antifungal susceptibility , Candida utilissepticemia , Cyberlinderajadinii , ITS sequencing and MALDI –TOF MS (Matrix Assisted Laser Desorption Ionization – Time of flight mass Spectrometry)
Funding
This study was supported by the:
  • Christian Medical College, Vellore (Award IRB Min No 13343)
    • Principle Award Recipient: SreelekshmiTS
© 2021 The Authors
  • This is an open-access article distributed under the terms of the Creative Commons Attribution NonCommercial License. The Microbiology Society waived the open access fees for this article.
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2021-10-11
2024-04-26
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Candida utilis: a rare cause of septicemia in children
Access Microbiology 3, 000281 (2021); https://doi.org/10.1099/acmi.0.000281
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