1887

Abstract

To better understand the prevalence of fluoroquinolone-resistant among sheltered companion animals, we conducted a screening study of 38 dogs and 78 cats and investigated the resistance mechanisms and characteristics of the isolates. Fluoroquinolone-resistant was detected in 18 dogs (47.4 %) and 14 cats (17.9 %). The isolates carried one to four mutations in the A, C and E genes of the quinolone resistance-determining region, and the number of mutations was proportional to the MIC for ciprofloxacin. For plasmid-mediated quinolone resistance, was detected in nine isolates, S in five isolates and B in one isolate. A relationship between the presence of these genes and MIC for ciprofloxacin was not apparent. Statistical analysis indicated that fluoroquinolone-resistant was widely distributed among sheltered companion animals with various attributes. This may relate to the wide dissemination of fluoroquinolone resistance among humans and other animals in Japan.

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2019-11-05
2019-11-20
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