1887

Abstract

under stress stores triacylglycerol (TG). There are 15 genes in that belong to a novel family of TG synthase genes (), but it is not known which of them is responsible for this accumulation of TG. In this paper, it is reported that H37Rv accumulated TG under acidic, static or hypoxic growth conditions, or upon treatment with NO, whereas TG accumulation was drastically reduced in the (Rv3130c) disrupted mutant. Complementation with restored this TG accumulation. C was a major fatty acid in this TG, indicating that the TGS1 gene product uses C fatty acid, which is known to be produced by the mycobacterial fatty acid synthase. TGS1 expressed in preferred C-CoA for TG synthesis. If TG storage is needed for the long-term survival of s under dormant conditions, the product could be a suitable target for antilatency drugs.

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2006-09-01
2019-11-18
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