1887

Abstract

Summary: A new M-type of group A streptococcus, provisionally designated type 65, is described. The vaccine and other initially isolated strains of this type attracted attention because of the T-agglutination reactions 2/25, not previously encountered among pyoderma streptococci. The investigations characterizing the strains as members of a new type were done with streptococci isolated from patients with pyoderma. However, type 65 was subsequently found to cause both pyoderma and acute pharyngitis.

The T-2 agglutination reactions encountered with original members of this type, plus the cross-reactions later seen with type 65 antiserum and M-type 2 streptococci, prompted a comparison of this new type with M-type 2 streptococci, including those with the T-2 agglutination and others with the 8-25-Imp.19 complex. The two M-antigens were clearly distinguished from one another in reciprocal bactericidal and precipitin tests with absorbed antisera. They were further distinguished in that all type 65 strains were opacity-factor (OF) negative, whereas type 2 streptococci were uniformly OF-positive. Most M-type 65 strains subsequently found in surveillance studies were shown to be members of the 8-25-1mp.19 T-complex. Type 65 is thus a newly described type which shares with M-types 55 and 57 a common T-agglutination pattern and, like members of these types, fails to produce opacity factor. In our collection of strains, from both pyoderma and pharyngitis, shown to be members of the 8-25-1mp.19 complex, and OF-negative, only type 65 has been identified to date. In contrast to types 55 and 57, the new type 65 does not appear to be of major importance in causing acute glomerulonephritis.

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1975-11-01
2024-12-13
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References

  1. Bergner-Rabinowitz S., Ofek I. 1974; A typing scheme for Streptococcus pyogenes based on T-antigen and enzyme production properties: an epidemiological survey in Israel. In Streptococcal Disease and the Community, Proceedings of the Fifth International Symposium on Streptococcus pyogenes pp. 19–25 Haverkorn M. J. Edited by Amsterdam and New York:: Excerpta Medica.;
    [Google Scholar]
  2. Dillon H. C. 1968; Impetigo contagiosa: suppurative and non-suppurative complications. I. Clinical, bacteriologic and epidemiologic characteristics of impetigo. American Journal of Diseases of Children 115:530–541
    [Google Scholar]
  3. Dillon H. C. 1972; Streptococcal infections of the skin and their complications: impetigo and nephritis. In Streptococci and Streptococcal diseases pp. 572–586 Wannamaker L. W., Matsen J. M. Edited by New York and London:: Academic Press.;
    [Google Scholar]
  4. Dillon H. C., Derrick C. W. 1974; Recent studies of streptococcal skin and throat infections in Alabama. In Streptococcal Disease and the Community, Proceedings of the Fifth International Symposium on Streptococcus pyogenes pp. 266–274 Haverkorn M. J. Edited by Amsterdam and New York:: Excerpta Medica.;
    [Google Scholar]
  5. Dillon H. C., Derrick C. W., Dillon M. S. 1974; M-antigens common to pyoderma and nephritis. Journal of Infectious Diseases 130:257–267
    [Google Scholar]
  6. Dillon H. C., Dillon M. S. A. 1974; New streptococcal serotypes causing pyoderma and acute glomerulonephritis - types 59, 60 and 61. Infection and Immunity 9:1070–1078
    [Google Scholar]
  7. Dillon H. C., Maxted W. R., Reeves M. S. 1968; Acute glomerulonephritis following skin infection due to streptococci of M-type 2. Lancet i:543–545
    [Google Scholar]
  8. Dillon H. C., Moody M. D., Maxted W. R., Parker M. T. 1967; The epidemiology of impetigo and acute glomerulonephritis. American Journal of Epidemiology 86:710–723
    [Google Scholar]
  9. Griffith F. 1934; Serological classification of Streptococcus pyogenes. Journal of Hygiene 34:542–584
    [Google Scholar]
  10. KÖhler W. 1974; Results of the Second International Streptococcus pyogenes Type Distribution Survey. In Streptococcal Disease and the Community, Proceedings of the Fifth International Symposium cn Streptococcus pyogenes pp. 10–13 Haverkorn M. J. Edited by Amsterdam and New York:: Excerpta Medica.;
    [Google Scholar]
  11. Lancefield R. C. 1933; A serological differentiation of human and other groups of streptococci. Journal of Experimental Medicine 57:571–595
    [Google Scholar]
  12. Lancefield R. C. 1957; Differentiation of group A streptococci with a common R antigen into 3 serological types, with special reference to the bactericidal test. Journal of Experimental Medicine 106:525–544
    [Google Scholar]
  13. Maxted W. R. 1953; The M and T antigens of Streptococcus pyogenes type 2. Journal of Pathology and Bacteriology 65:345–354
    [Google Scholar]
  14. Maxted W. R., Widdowson J. P., Fraser C. A. M. 1974; Antibody to streptococcal serum opacity factor. In Streptococcal Disease and the Community, Proceedings of the Fifth International Symposium on Streptococcus pyogenes pp. 132–136 Haverkorn M. J. Edited by Amsterdam and New York:: Excerpta Medica.;
    [Google Scholar]
  15. Maxted W. R., Widdowson J. P., Fraser C. A. M., Ball L. C., Bassett D. C. J. 1973; The use of the serum opacity reaction in the typing of group A streptococci. Journal of Medical Microbiology 6:83–90
    [Google Scholar]
  16. Moody M. D., Padula J., Lizana D., Hall C. T. 1965; Epidemiologic characterization of group A streptococci by T-agglutination and M-precipitation tests in the Public Health Laboratory. Health Laboratory Science 2:149–162
    [Google Scholar]
  17. Parker M. T., Bassett D. C. J., Maxted W. R., Arneaud J. D. 1968; Acute glomerulonephritis in Trinidad: serological typing of group A streptococci. Journal of Hygiene 66:657–675
    [Google Scholar]
  18. Potter E. V., Moran A. F., Poon-King T., Earle D. P. 1968; Characteristics of beta hemolytic streptococci associated with acute glomerulonephritis in Trinidad, West Indies. Journal of Laboratory and Clinical Medicine 71:126–137
    [Google Scholar]
  19. Rotta J., Krause R. M., Lancefield R. C., Everly W., Lackland H. 1971; New approaches for the laboratory recognition of M types of group A streptococci. Journal of Experimental Medicine 134:1298–1315
    [Google Scholar]
  20. Swift H. F., Wilson A. T., Lancefield R. C. 1943; Typing group A hemolytic streptococci by M precipitin reactions in capillary pipettes. Journal of Experimental Medicine 78:127–133
    [Google Scholar]
  21. Top F. H.Jun Wannamaker L. W., Maxted W. R., Anthony B. F. 1967; M antigens among group Astreptococci isolated from skin lesions. Journal of Experimental Medicine 126:667–685
    [Google Scholar]
  22. Wannamaker L. W. 1970; Differences between streptococcal infections of the throat and of the skin. New England Journal of Medicine 282:23–3178–85
    [Google Scholar]
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