1887

Abstract

Summary: A lysine bradytroph of Wis. 54–1255 was isolated. The mutant (l) grew with -aminoadipic acid and excreted homocitrate. accumulation of homocitrate, which did not require protein synthesis, was markedly reduced by lysine. These results indicate that lysine diminution of penicillin production is caused by feedback inhibition of homocitrate synthase, thus limiting the supply of -aminoadipic acid available for penicillin biosynthesis.

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/content/journal/micro/10.1099/00221287-82-1-143
1974-05-01
2022-01-21
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