Summary: The regulation of the first step in methionine biosynthesis, homoserine--transsuccinylase, has been examined in a methionine-requiring mutant of the blue-green alga Using an improved assay for homoserine--transsuccinylase, no evidence of derepression of the biosynthesis of this enzyme was found, even under conditions of acute methionine starvation. End-product inhibition of the enzyme by homoserine, cystathionine and methionine was demonstrated, and shown in the latter case to be of an allosteric nature. The lack of transcription control of this enzyme is discussed as an example of a general phenomenon in this group of micro-organisms.


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