1887

Abstract

SUMMARY: grown aerobically in glucose + salts medium excretes acetate. On glucose exhaustion, the cells synthesize the enzymes of the glyoxylate bypass which permits growth on acetate as sole source of carbon and energy. Concurrently, the activity of isocitrate dehydrogenase falls to 20% and, when the acetate is exhausted, is restored to 75% of the original level. Similar results are obtained after growth on substrates (e.g. glycerol) which do not promote excretion of acetate, provided acetate is added to the medium at the end of growth. This control of isocitrate dehydrogenase activity is apparently a mechanism which restricts the flow of carbon round the tricarboxylic acid cycle and favours operation of the glyoxylate bypass.

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/content/journal/micro/10.1099/00221287-65-1-57
1971-01-01
2021-10-24
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