1887

Abstract

Restriction of the growth of was studied in wild-type and p47-deficient macrophages. The ability of gamma interferon and tumour necrosis factor alpha to induce antimycobacterial activity in bone-marrow-derived macrophages or the expression of the NRAMP1-mediated resistance to were not affected by the deficiency in p47. The addition of exogenous iron increased mycobacterial growth in macrophages expressing a functional NRAMP1 protein or a mutant NRAMP1 protein. Reactive oxygen species are therefore not involved in the constitutive or induced anti- activities of the mouse macrophage.

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2002-10-01
2020-01-21
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