SUMMARY: A neamine-resistant mutant of LT2 with altered translational fidelity was isolated. The phenomenon was expressed in severe restriction of amber suppressor activity as well as in decreased misreading of poly(U) RNA The mutation conferring resistance to neamine was mapped at 72 min on the genetic map, where some of the ribosomal genes have already been mapped. This location indicates that the neamine-resistant phenotype as well as an altered translational fidelity could be a consequence of an alteration of the ribosomal structure.


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