1887

Abstract

Melanogenesis in begins with the oxidation of dihydroxyphenylalanine by the enzyme phenol oxidase. The succeeding steps are very rapid. Two intermediates, dopachrome and 5,6-dihydroxyindole, have been isolated and characterized by high performance liquid chromatography. A pathway of melanin formation in is proposed, based on the presence of these intermediates.

Loading

Article metrics loading...

/content/journal/micro/10.1099/00221287-134-4-1037
1988-04-01
2024-04-26
Loading full text...

Full text loading...

/deliver/fulltext/micro/134/4/mic-134-4-1037.html?itemId=/content/journal/micro/10.1099/00221287-134-4-1037&mimeType=html&fmt=ahah

References

  1. Butler W. T., Alling D. W., Anderson J., Utz J. P. 1964; Diagnostic and prognostic value of clinical and laboratory finding in cryptococcal meningitis. New England Journal of Medicine 270:59–67
    [Google Scholar]
  2. Cooper B. H., Silva-Hutner M. 1985; Yeasts of medical importance. In Manual of Clinical Microbiology pp. 526–541 Lennette E. H., Balows A., Hausler W. J. Jr Shadomy H. J. Edited by Washington, DC: American Society for Microbiology;
    [Google Scholar]
  3. Geis P. A., Wheeler M. H., Szaniszlo P. J. 1984; Pentaketide metabolites of melanin synthesis in the dematiaceous fungus Wangiella dermatidis. Archives of Microbiology 137:324–328
    [Google Scholar]
  4. Hammerman K. J., Powell K. E., Tosh F. E. 1974; The incidences of hospitalized cases of systemic mycotic infections. Sabouraudia 12:33–45
    [Google Scholar]
  5. KÖrner M., Pawelek J. 1980; Dopachrome conversion: a possible control point in melanin biosynthesis. Journal of Investigative Dermatology 75:192–195
    [Google Scholar]
  6. Kwon-Chung K. J., Hill W. B., Bennett J. E. 1981; New special stain for histopathological diagnosis of cryptococcosis. Journal of Clinical Microbiology 13:383–387
    [Google Scholar]
  7. Mason H. S. 1955; Comparative biochemistry of the phenolase complex. Advances in Enzymology 16:105–184
    [Google Scholar]
  8. Pawelek J., KÖrner A., Bergstrom A., Bologna J. 1980; New regulators of melanin biosynthesis and the autodestruction of melanin cells. Nature; London: 286617–619
    [Google Scholar]
  9. Polacheck I., Hearing V. J., Kwon-Chung K. J. 1982; Biochemical studies of phenoloxidase and utilization of catecholamines in Cryptococcus neoformans. Journal of Bacteriology 150:1212–1220
    [Google Scholar]
  10. Quinn C. T., Mann J. M., Curran J. W., Piot P. 1986; AIDS in Africa: an epidemologic paradigm. Science 234:955–963
    [Google Scholar]
  11. Rhodes J. C., Polacheck I., Kwon-Chung K. J. 1982; Phenoloxidase activity and virulence in isogenic strains of Cryptococcus neoformans. Infection and Immunity 36:1175–1184
    [Google Scholar]
  12. Ro J. Y., Sang S. L., Ayala A. G. 1987; Advantage of Fontana-Masson stain in capsule- deficient cryptococcal infection. Archives of Pathology and Laboratory Medicine 111:53–57
    [Google Scholar]
  13. Rodrigues De Miranda L. 1984; Cryptococcus Kutzing emend. Phaff et Spencer. In the Yeasts, a Taxonomic Study pp. 845–872 Kreger-van Rij N. J. W. Edited by Amsterdam: Elsevier;
    [Google Scholar]
  14. Staib F. 1962; Cryptococcus neoformans and Guizotia abyssinica (syn. G. oleifera D.C.). Zentralblatt für Bakteriologie, Parasitenkinde und Hygiene 148:466–475
    [Google Scholar]
  15. Taylor B. E., Wheeler M. H., Szaniszlo P. J. 1987; Evidence for pentaketide melanin biosynthesis in dematiaceous human pathogenic fungi. Mycologia 79:320–322
    [Google Scholar]
  16. Zuger A., Louie E., Holzman R. S., Simberkoff M. S., Rahal J. J. 1986; Cryptococcal disease in patients with the acquired immunodeficiency syndrome. Annals of Internal Medicine 104:234–240
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/micro/10.1099/00221287-134-4-1037
Loading
/content/journal/micro/10.1099/00221287-134-4-1037
Loading

Data & Media loading...

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error