SUMMARY: Resistance to oleandomycin in , the producer organism, was studied. The organism was highly resistant to the antibiotic but sensitive to other macrolides and lincosamides. Protein synthesis by mycelium of was more resistant to oleandomycin than that by mycelium of G, an oleandomycin-sensitive strain, and this resistance was dependent on the age of the culture, older mycelium of being more resistant to oleandomycin than young mycelium. [H]Oleandomycin was capable of binding to the same extent to the 50S subunits of the ribosomes of both organisms. Oleandomycin also inhibited protein synthesis by ribosomes obtained from an oleandomycin-production medium at the time when maximum levels of oleandomycin were being produced. A clear difference between the ability of the two organisms to incorporate exogenous oleandomycin was observed. Thus, while G took up oleandomycin, showed a decreased permeability to the antibiotic, suggesting a role for cell permeability in self-resistance.


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