1887

Abstract

The effects of the microtubule inhibitors colchicine, parbendazole and nocodazole on the growth of myxamoebae of were closely paralleled by the effects of these drugs on the assembly of purified amoebal microtubule protein. Colchicine at 100 did not inhibit amoebal growth and did not inhibit formation, or depolymerization, of amoebal microtubules. The benzimidazole carbamate derivatives nocodazole and parbendazole were very effective in both inhibiting growth and inhibiting the assembly of amoebal microtubule protein. Parbendazole was the most effective.

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1981-01-01
2021-07-29
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