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Volume 9, Issue 2

A systematic review of economic evaluations of whole-genome sequencing for the surveillance of bacterial pathogens Open Access

This article is part of the Implementation of Genomics in Clinical and Public Health Microbiology collection 

Abstract

Whole-genome sequencing (WGS) has unparalleled ability to distinguish between bacteria, with many public health applications. The generation and analysis of WGS data require significant financial investment. We describe a systematic review summarizing economic analyses of genomic surveillance of bacterial pathogens, reviewing the evidence for economic viability. The protocol was registered on PROSPERO (CRD42021289030). Six databases were searched on 8 November 2021 using terms related to ‘WGS’, ‘population surveillance’ and ‘economic analysis’. Quality was assessed with the Drummond–Jefferson checklist. Following data extraction, a narrative synthesis approach was taken. Six hundred and eighty-one articles were identified, of which 49 proceeded to full-text screening, with 9 selected for inclusion. All had been published since 2019. Heterogeneity was high. Five studies assessed WGS for hospital surveillance and four analysed foodborne pathogens. Four were cost–benefit analyses, one was a cost–utility analysis, one was a cost-effectiveness analysis, one was a combined cost-effectiveness and cost–utility analysis, one combined cost-effectiveness and cost–benefit analyses and one was a partial analysis. All studies supported the use of WGS as a surveillance tool on economic grounds. The available evidence supports the use of WGS for pathogen surveillance but is limited by marked heterogeneity. Further work should include analysis relevant to low- and middle-income countries and should use real-world effectiveness data.

  • Received:
  • Accepted:
  • Published Online:
Keyword(s): antimicrobial resistance , economic evaluation , foodborne pathogens , infection prevention and control , systematic review and whole-genome sequencing
Funding
This study was supported by the:
  • Rosetrees Trust
    • Principle Award Recipient: ElitaJauneikaite
  • Wellcome Trust (Award 203919/Z/16/Z)
    • Principle Award Recipient: VivienViolet Huia Price
© 2023 The Authors
  • This is an open-access article distributed under the terms of the Creative Commons Attribution License.
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2023-02-15
2024-05-02
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A systematic review of economic evaluations of whole-genome sequencing for the surveillance of bacterial pathogens
M Gen 9, 000947 (2023); https://doi.org/10.1099/mgen.0.000947
/content/journal/mgen/10.1099/mgen.0.000947
/content/journal/mgen/10.1099/mgen.0.000947
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