species are curved, motile Gram-negative bacilli found in estuarine and marine environments, and are known to cause to gastroenteritis, skin and soft tissue infections, and septicaemia. While not responsible for cholera epidemics, non-O1/O139 (NOVC) is increasingly reported as a cause of gastroenteritis.

A 66-year-old man presented to an emergency department with a 1 week history of epigastric pain, emesis and fever. Blood cultures drawn on admission initially demonstrated Gram-negative bacilli, and ultimately grew NOVC, which was later confirmed by matrix-assisted laser desorption ionization-time of flight MS. Subsequent history revealed that the patient had eaten fish and seafood prior to falling ill. He was treated with intravenous ceftriaxone and oral doxycycline while admitted, and oral ciprofloxacin and doxycycline upon discharge. His bacteraemia was believed to be secondary to altered gut anatomy from prior surgery and proton-pump inhibitor use.

Risk factors for NOVC bacteraemia include cirrhosis, immunosuppression and other forms of liver disease. Cases are often linked to a history of seafood ingestion when water temperatures rise, enabling species to proliferate. While the optimal management of NOVC bacteraemia is unclear, a combination of a third-generation cephalosporin with a tetracycline has been suggested. Physicians should maintain a high index of suspicion for this pathogen when evaluating ill patients with a history of liver disease and seafood ingestion.


Article metrics loading...

Loading full text...

Full text loading...



  1. Deshayes S, Daurel C, Cattoir V, Parienti JJ, Quilici ML et al. Non-O1, non-O130 Vibrio cholerae bacteraemia: case report and literature review. Springerplus 2015; 4:575 [View Article][PubMed]
    [Google Scholar]
  2. Centers for Disease Control and Prevention. 2016; Vibrio species causing vibriosis: information for health professionals and laboratorians. www.cdc.gov/vibrio/healthcare.html [accessed 10 October 2016]
  3. Nair GB, Ramamurthy T, Bhattacharya SK, Mukhopadhyay AK, Garg S et al. Spread of Vibrio cholerae O139 Bengal in India. J Infect Dis 1994; 169:1029–1034 [View Article][PubMed]
    [Google Scholar]
  4. Bavishi C, Dupont HL. Systematic review: the use of proton pump inhibitors and increased susceptibility to enteric infection. Aliment Pharmacol Ther 2011; 34:1269–1281 [View Article][PubMed]
    [Google Scholar]
  5. United States Environmental Protection Agency 2016; Climate change indicators: sea surface temperature. www.epa.gov/climate-indicators/climate-change-indicators-sea-surface-temperature [accessed 28 Feb 2017]

Most cited this month Most Cited RSS feed

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error