1887

Abstract

Introduction:

Viral protein R (Vpr) of human immunodeficiency virus type 1 (HIV‐1) has been described as being involved in the progression of AIDS, and specific mutations are associated with long‐term non‐progressor patients.

Case presentation:

We describe the case of a child with repeated ear infections who was otherwise healthy. The patient, a 5‐year‐old boy, was HIV‐1 positive and the viral load at admission was 1 073 899 RNA copies ml and 0 % CD4 lymphocytes. A detailed study of the gene sequence of the child revealed mutations leading to amino acid substitutions at positions 3 and 77.

Conclusion:

The case reported provides clinical support of previous findings that show that the R77Q and Q3R HIV‐1 Vpr variants are associated with patients with delayed disease progression.

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2014-12-01
2019-10-22
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