1887

Abstract

Internalin A is a surface protein of the facultative intracellular pathogen that interacts with the human host cell protein E-cadherin to facilitate invasion of epithelial cells. A single amino acid substitution at position 16 in mouse E-cadherin prevents this interaction. Synthetic polypeptides of 30 aa encompassing position 16 of human and mouse E-cadherin were tested for their ability to inhibit invasion of Caco-2, HepG2 and TIB73 cell lines by . Only the human-derived peptide was capable of inhibiting invasion in the human-origin Caco-2 and HepG2 cell lines. These findings demonstrate that small polypeptides can inhibit invasion of biologically relevant cell types by and may be potentially useful as therapeutic agents .

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2007-08-01
2019-10-18
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