1887

Abstract

There is limited information regarding the molecular epidemiology and antifungal susceptibilities of isolates using the Neo-Sensitabs method in patients with vulvovaginal candidiasis (VVC). From August 2012 to March 2013, 301 non-pregnant patients aged 18–50 years with suspected VVC were prospectively screened at a teaching hospital in southern China. The vaginal isolates were identified by DNA sequencing of internal transcribed spacer and the D1/D2 domain. Antifungal susceptibility testing of seven antifungal agents was performed using the Neo-Sensitabs tablet diffusion method. species were isolated from 186 cases (61.79 %). The most common pathogen was (91.4 %), followed by (4.3 %), (3.2 %) and (1.1 %). The susceptibility rates to were higher for caspofungin, voriconazole and fluconazole than those for itraconazole, miconazole, ketoconazole and terbinafine (<0.01). The resistance rates to were 4.7, 6.5, 7.1, 7.6, 12.3, 27.7 and 74.7 % for caspofungin, miconazole, itraconazole, voriconazole, fluconazole, ketoconazole and terbinafine, respectively. No drugs tested apart from fluconazole exhibited differences in resistance between and non-albicans isolates. The results demonstrate that, using DNA sequencing, is the most common isolate from Chinese patients with VVC. Caspofungin, voriconazole and fluconazole may be preferable to other azoles and terbinafine in the treatment of VVC.

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/content/journal/jmm/10.1099/jmm.0.000024
2015-04-01
2019-09-22
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