Parenterally vaccinated rabbits and guinea-pigs, and passively immunised baby rabbits, were challenged intra-intestinally with graded doses of a cholera vibrio strain. All vibrio vaccines, possibly including one made from an avirulent water vibrio, appeared fairly protective. Live and heat-killed vaccines seemed equally effective, and were superior to a formolised vaccine. The immunity seemed antibacterial, but possibly independent of the agglutinating antibodies. Suitability of a vibrio strain for vaccine production was not reflected in its specific serotype. Development of maximum resistance seemed to take several weeks after adequate dosage, and repetition of doses during this period showed no immediate advantage. The duration of immunity was, however, not ascertained.


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