1887

Abstract

We identified sequences from two distantly related papillomaviruses in genital warts from two Burmeister's porpoises, including a PV antigen-positive specimen, and characterized papillomavirus type 1 (PsPV-1). The PsPV-1 genome comprises 7879 nt and presents unusual features. It lacks an E7, an E8 and a bona fide E5 open reading frame (ORF) and has a large E6 ORF. PsPV-1 L1 ORF showed the highest percentage of nucleotide identity (54–55 %) with human papillomavirus type 5, bovine papillomavirus type 3 (BPV-3) and papillomavirus type 2 (TtPV-2). This warrants the classification of PsPV-1 as the prototype of the genus. PsPV-1 clustered with TtPV-2 in the E6 and E1E2 phylogenetic trees and with TtPV-2 and BPV-3 in the L2L1 tree. This supports the hypothesis that PV evolution may not be monophyletic across all genes.

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2007-07-01
2019-11-13
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References

  1. Androphy, E. J., Lowy, D. R. & Schiller, J. T. ( 1987; ). Bovine papillomavirus E2 transactivating gene product binds to specific sites in papillomavirus DNA. Nature 325, 70–73.[CrossRef]
    [Google Scholar]
  2. Bravo, I. G. & Alonso, A. ( 2004; ). Mucosal human papillomaviruses encode four different E5 proteins whose chemistry and phylogeny correlate with malignant and benign growth. J Virol 78, 13613–13626.[CrossRef]
    [Google Scholar]
  3. Bravo, I. G. & Alonso, A. ( 2006; ). Phylogeny and evolution of papillomaviruses based on the E1 and E2 proteins. Virus Genes 34, 249–262.
    [Google Scholar]
  4. Cassonnet, P., Van Bressem, M.-F., Desaintes, C., Van Waerebeek, K. & Orth, G. ( 1998; ). Papillomaviruses cause genital warts in small cetaceans from Peru. The World Marine Mammal Science Conference, Monaco, January 1998.
  5. Chan, S.-Y., Bernard, H.-U., Ratterree, M., Birkebak, T. A., Faras, A. J. & Ostrow, R. S. ( 1997; ). Genomic diversity and evolution of papillomaviruses in rhesus monkeys. J Virol 71, 4938–4943.
    [Google Scholar]
  6. de Roda Husman, A.-M., Walboomers, J. M. M., van den Brule, A. J. C., Meijer, C. J. L. M. & Snijders, P. J. F. ( 1995; ). The use of general primers GP5 and GP6 elongated at their 3′ ends with adjacent highly conserved sequences improves human papillomavirus detection by PCR. J Gen Virol 76, 1057–1062.[CrossRef]
    [Google Scholar]
  7. de Villiers, E.-M., Fauquet, C., Broker, T. R., Bernard, H.-U. & zur Hausen, H. ( 2004; ). Classification of papillomaviruses. Virology 324, 17–27.[CrossRef]
    [Google Scholar]
  8. Fordyce, R. E. & Barnes, L. G. ( 1994; ). The evolutionary history of whales and dolphins. Annu Rev Earth Planet Sci 22, 419–455.[CrossRef]
    [Google Scholar]
  9. García-Vallvé, S., Alonso, A. & Bravo, I. G. ( 2005; ). Papillomaviruses: different genes have different histories. Trends Microbiol 13, 514–521.[CrossRef]
    [Google Scholar]
  10. Gottschling, M., Köhler, A., Stockfleth, E. & Nindl, I. ( 2006; ). Phylogenetic analysis of beta-papillomaviruses as inferred from nucleotide and amino acid sequence data. Mol Phylogenet Evol 42, 213–222.
    [Google Scholar]
  11. Howley, P. M. & Lowy, D. R. ( 2001; ). Papillomaviruses and their replication. In Fields Virology, 4th edn, vol. 2, pp. 2197–2230. Edited by D. M. Knipe & P. M. Howley. Philadelphia, PA: Lippincott Williams & Wilkins.
  12. ICTV ( 2006; ). Papillomaviridae. In ICTVdB – The Universal Virus Database, version 4. Edited by C. Büchen-Osmond. New York: Columbia University. http://www.ncbi.nlm.nih.gov/ICTVdb/Ictv/index.htm
  13. Jackson, M. E., Pennie, W. D., McCaffery, R. E., Smith, K. T., Grindlay, G. J. & Campo, M. S. ( 1991; ). The B subgroup bovine papillomaviruses lack an identifiable E6 open reading frame. Mol Carcinog 4, 382–387.[CrossRef]
    [Google Scholar]
  14. Kawashima, M., Favre, M., Obalek, S., Jablonska, S. & Orth, G. ( 1990; ). Premalignant lesions and cancers of the skin in the general population. Evaluation of the role of human papillomaviruses. J Invest Dermatol 95, 537–542.[CrossRef]
    [Google Scholar]
  15. Kiyono, T., Hiraiwa, A., Fujita, M., Hayashi, Y., Akiyama, T. & Ishibashi, M. ( 1997; ). Binding of high-risk human papillomavirus E6 oncoproteins to the human homologue of the Drosophila discs large tumor suppressor protein. Proc Natl Acad Sci U S A 94, 11612–11616.[CrossRef]
    [Google Scholar]
  16. Krogh, A., Larsson, B., von Heijne, G. & Sonnhammer, E. L. ( 2001; ). Predicting transmembrane protein topology with a hidden Markov model: application to complete genomes. J Mol Biol 305, 567–580.[CrossRef]
    [Google Scholar]
  17. Longuet, M., Beaudenon, S. & Orth, G. ( 1996; ). Two novel genital human papillomavirus (HPV) types, HPV68 and HPV70, related to the potentially oncogenic HPV39. J Clin Microbiol 34, 738–744.
    [Google Scholar]
  18. Lowy, D. R. & Howley, P. M. ( 2001; ). Papillomaviruses. In Fields Virology, 4th edn, vol. 2, pp. 2231–2264. Edited by D. M. Knipe & P. M. Howley. Philadelphia, PA: Lippincott Williams & Wilkins.
  19. Münger, K., Baldwin, A., Edwards, K. M., Hayakawa, H., Nguyen, C. L., Owens, M., Grace, M. & Huh, K. W. ( 2004; ). Mechanisms of human papillomavirus-induced oncogenesis. J Virol 78, 11451–11460.[CrossRef]
    [Google Scholar]
  20. Narechania, A., Chen, Z., DeSalle, R. & Burk, R. D. ( 2005; ). Phylogenetic incongruence among oncogenic genital Alpha human papillomaviruses. J Virol 79, 15503–15510.[CrossRef]
    [Google Scholar]
  21. Nikaido, M., Matsuno, F., Hamilton, H., Brownell, R., Jr, Cao, Y., Ding, W., Zuoyan, Z., Shedlock, A. M., Fordyce, N. & other authors ( 2001; ). Retroposon analysis of major cetacean lineages: the monophyly of toothed whales and the paraphyly of river dolphins. Proc Natl Acad Sci U S A 98, 7384–7389.[CrossRef]
    [Google Scholar]
  22. Nominé, Y., Masson, M., Charbonnier, S., Zanier, K., Ristriani, T., Deryckère, F., Sibler, A.-P., Desplancq, D., Atkinson, R. A. & other authors ( 2006; ). Structural and functional analysis of E6 oncoprotein: insights in the molecular pathways of human papillomavirus-mediated pathogenesis. Mol Cell 21, 665–678.[CrossRef]
    [Google Scholar]
  23. Nonnenmacher, M., Salmon, J., Jacob, Y., Orth, G. & Breitburd, F. ( 2006; ). Cottontail rabbit papillomavirus E8 protein is essential for wart formation and provides new insights into viral pathogenesis. J Virol 80, 4890–4900.[CrossRef]
    [Google Scholar]
  24. O'Connor, M., Shan, S.-Y. & Bernard, H.-U. ( 1995; ). Transcription factor binding sites in the long control region of genital HPVs. In Human Papillomaviruses 1995. A Compilation and Analysis of Nucleic Acid and Amino Acid Sequences, vol. 3, pp. 21–40. Edited by G. Myers, H. Delius, J. Icenogle, H.-U. Bernard, C. Baker, A. Halpern & C. Wheeler. Los Alamos, NM : Los Alamos National Laboratory.
  25. Oh, S. T., Longworth, M. S. & Laimins, L. A. ( 2004; ). Roles of the E6 and E7 proteins in the life cycle of low-risk human papillomavirus type 11. J Virol 78, 2620–2626.[CrossRef]
    [Google Scholar]
  26. Orth, G. ( 2006; ). Genetics of epidermodysplasia verruciformis: insights into host defense against papillomaviruses. Semin Immunol 18, 362–374.[CrossRef]
    [Google Scholar]
  27. Rector, A., Lacave, G., Mostmans, S., Van Doorslaer, K., Rehtanz, M., Salbany, A., Roque, L., Ghim, S.-J., Bennett Jenson, A. & other authors ( 2006; ). The genetic characterization of a novel close-to-root papillomavirus in a bottlenose dolphin: Tursiops truncatus papillomavirus type 1 (TtPV-1). Abstracts of the 34th European Association for Aquatic Mammals (EAAM) Conference, Riccione, Italy, 17–20 March 2006.
  28. Rehtanz, M., Ghim, S. J., Rector, A., Van Ranst, M., Fair, P., Bossart, G. D. & Jenson, A. B. ( 2006; ). Isolation and characterization of the first American bottlenose dolphin papillomavirus: Tursiops truncatus papillomavirus type 2. J Gen Virol 87, 3559–3565.[CrossRef]
    [Google Scholar]
  29. Short, J. M., Fernandez, J. M., Sorge, J. A. & Huse, W. D. ( 1988; ). λZAP: a bacteriophage λ expression vector with in vivo excision properties. Nucleic Acids Res 16, 7583–7600.[CrossRef]
    [Google Scholar]
  30. Terai, M., DeSalle, R. & Burk, R. D. ( 2002; ). Lack of canonical E6 and E7 open reading frames in bird papillomaviruses: Fringilla coelebs papillomavirus and Psittacus erithracus timneh papillomavirus. J Virol 76, 10020–10023.[CrossRef]
    [Google Scholar]
  31. Ting, Y. & Manos, M. ( 1990; ). Detection and typing of genital human papillomaviruses. In PCR Protocols: A Guide to Methods and Applications, pp. 356–367. Edited by M. A. Innis, D. H. Gelfand, J. J. Sninsky & T. J.White. San Diego: Academic Press.
  32. Ustav, M., Ustav, E., Szymansky, P. & Stenlund, A. ( 1991; ). Identification of the origin of replication of bovine papillomavirus and characterization of the viral origin recognition factor E1. EMBO J 10, 4321–4329.
    [Google Scholar]
  33. Van Bressem, M.-F., Van Waerebeek, K., Piérard, G. E. & Desaintes, C. ( 1996; ). Genital and lingual warts in small cetaceans from coastal Peru. Dis Aquat Organ 26, 1–10.[CrossRef]
    [Google Scholar]
  34. Van Bressem, M.-F., Kastelein, R. A., Flamant, P. & Orth, G. ( 1999; ). Cutaneous papillomavirus infection in a harbour porpoise (Phocoena phocoena) from the North Sea. Vet Rec 144, 592–593.[CrossRef]
    [Google Scholar]
  35. Van Ranst, M., Kaplan, J. B. & Burk, R. D. ( 1992; ). Phylogenetic classification of human papillomaviruses: correlation with clinical manifestations. J Gen Virol 73, 2653–2660.[CrossRef]
    [Google Scholar]
  36. Waddell, V. G., Milinkovitch, M. C., Bérubé, M. & Stanhope, M. J. ( 2000; ). Molecular phylogenetic examination of the Delphinoidea trichotomy: congruent evidence from three nuclear loci indicates that porpoises (Phocoenidae) share a more recent common ancestry with white whales (Monodontidae) than they do with true dolphins (Delphinidae). Mol Phylogenet Evol 15, 314–318.[CrossRef]
    [Google Scholar]
  37. Yuan, H., Ghim, S., Newsome, J., Apolinario, T., Olcese, V., Martin, M., Delius, H., Felsburg, P., Jenson, B. & other authors ( 2007; ). An epidermotropic canine papillomavirus with malignant potential contains an E5 gene and establishes a unique genus. Virology 359, 28–36.[CrossRef]
    [Google Scholar]
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