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1887

Journal of General Virology header logo Journal of General Virology

Volume 87, Issue 1

Isolation and characterization of a chimpanzee alphaherpesvirus No Access

Abstract

Although both beta- and gammaherpesviruses indigenous to great-ape species have been isolated, to date all alphaherpesviruses isolated from apes have proven to be human viruses [herpes simplex virus types 1 (HSV1) and 2 (HSV2) or varicella-zoster virus]. If the alphaherpesviruses have co-evolved with their host species, some if not all ape species should harbour their own alphaherpesviruses. Here, the isolation and characterization of an alphaherpesvirus from a chimpanzee (ChHV) are described. Sequencing of a number of genes throughout the ChHV genome indicates that it is collinear with that of HSV. Phylogenetic analyses place ChHV in a clade with HSV1 and HSV2, the alphaherpesviruses of Old World monkeys comprising a separate clade. Analysis of reactivity patterns of HSV2-immune human sera and ChHV-immune chimpanzee sera by competition ELISA support this relationship. Phylogenetic analyses also place ChHV rather than HSV1 as the closest relative of HSV2.

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/content/journal/jgv/10.1099/vir.0.81606-0
2006-01-01
2025-12-11

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/content/journal/jgv/10.1099/vir.0.81606-0
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Isolation and characterization of a chimpanzee alphaherpesvirus
J. Gen. Virol. 87, 11 (2006); https://doi.org/10.1099/vir.0.81606-0
/content/journal/jgv/10.1099/vir.0.81606-0
/content/journal/jgv/10.1099/vir.0.81606-0
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