1887

Abstract

Rinderpest, or cattle plague, is caused by (RPV), which is related most closely to human (MV), both being members of the genus , a group of viruses known to have strong immunosuppressive effects and . Here, it was shown that peripheral blood mononuclear cells (PBMCs) isolated from cattle experimentally infected with either wild-type or vaccine strains of RPV impaired the proliferation of PBMCs derived from uninfected animals; however, in contrast to either mild or virulent strains of wild-type virus, the inhibition induced by the vaccine was both weak and transient. Flow-cytometric analysis of PBMCs obtained from cattle infected with different strains of RPV showed that the proportion of infected cells was virus dose-dependent and correlated with lymphoproliferative suppression.

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2005-12-01
2019-11-19
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