1887

Abstract

Recently, pathological prion protein (PrP) was detected in muscle from sheep infected with scrapie, the archetype of transmissible spongiform encephalopathies (TSEs). This finding has highlighted the question of whether mammalian muscle may potentially also provide a reservoir for TSE agents related to bovine spongiform encephalopathy (BSE) and variant Creutzfeldt–Jakob Disease (vCJD). Here, results are reported from studies in hamsters and mice that provide direct experimental evidence, for the first time, of BSE- and vCJD-associated PrP deposition in muscles. Our findings emphasize the need for further assessment of possible public-health risks from TSE involvement of skeletal muscle.

Loading

Article metrics loading...

/content/journal/jgv/10.1099/vir.0.81277-0
2006-01-01
2019-11-19
Loading full text...

Full text loading...

/deliver/fulltext/jgv/87/1/251.html?itemId=/content/journal/jgv/10.1099/vir.0.81277-0&mimeType=html&fmt=ahah

References

  1. Andréoletti, O., Simon, S., Lacroux, C. & 11 other authors ( 2004; ). PrPSc accumulation in myocytes from sheep incubating natural scrapie. Nat Med 10, 591–593.[CrossRef]
    [Google Scholar]
  2. Bartz, J. C., Kincaid, A. E. & Bessen, R. A. ( 2003; ). Rapid prion neuroinvasion following tongue infection. J Virol 77, 583–591.[CrossRef]
    [Google Scholar]
  3. Bosque, P. J., Ryou, C., Telling, G., Peretz, D., Legname, G., DeArmond, S. J. & Prusiner, S. B. ( 2002; ). Prions in skeletal muscle. Proc Natl Acad Sci U S A 99, 3812–3817.[CrossRef]
    [Google Scholar]
  4. Brown, P. & Cervenakova, L. ( 2005; ). A prion lexicon (out of control). Lancet 365, 122.[CrossRef]
    [Google Scholar]
  5. Casalone, C., Corona, C., Crescio, M. I., Martucci, F., Mazza, M., Ru, G., Bozzetta, E., Acutis, P. L. & Caramelli, M. ( 2005; ). Pathological prion protein in the tongues of sheep infected with naturally occurring scrapie. J Virol 79, 5847–5849.[CrossRef]
    [Google Scholar]
  6. Cervenakova, L., Yakovleva, O., McKenzie, C., Kolchinsky, S., McShane, L., Drohan, W. N. & Brown, P. ( 2003; ). Similar levels of infectivity in the blood of mice infected with human-derived vCJD and GSS strains of transmissible spongiform encephalopathy. Transfusion 43, 1687–1694.[CrossRef]
    [Google Scholar]
  7. European Commission ( 2002; ). Update of the opinion on TSE infectivity distribution in ruminant tissues. http://europa.eu.int/comm/food/fs/sc/ssc/out296_en.pdf
  8. European Food Safety Authority ( 2005; ). Statement on the assessment of safety with respect to the consumption of goat meat and goat meat products in relation to BSE/TSE. 31 January 2005. Scientific Panel on Biological Hazards. http://www.efsa.eu.int/science/biohaz/biohaz_documents/787_en.html
  9. Glatzel, M., Abela, E., Maissen, M. & Aguzzi, A. ( 2003; ). Extraneural pathologic prion protein in sporadic Creutzfeldt–Jakob disease. N Engl J Med 349, 1812–1820.[CrossRef]
    [Google Scholar]
  10. Kovacs, G. G., Lindeck-Pozza, E., Chimelli, L., Araújo, A. Q. C., Gabbai, A. A., Ströbel, T., Glatzel, M., Aguzzi, A. & Budka, H. ( 2004; ). Creutzfeldt-Jakob disease and inclusion body myositis: abundant disease-associated prion protein in muscle. Ann Neurol 55, 121–125.[CrossRef]
    [Google Scholar]
  11. Maignien, T., Lasmézas, C. I., Beringue, V., Dormont, D. & Deslys, J.-P. ( 1999; ). Pathogenesis of the oral route of infection of mice with scrapie and bovine spongiform encephalopathy agents. J Gen Virol 80, 3035–3042.
    [Google Scholar]
  12. McBride, P. A., Schulz-Schaeffer, W. J., Donaldson, M., Bruce, M., Diringer, H., Kretzschmar, H. A. & Beekes, M. ( 2001; ). Early spread of scrapie from the gastrointestinal tract to the central nervous system involves autonomic fibers of the splanchnic and vagus nerves. J Virol 75, 9320–9327.[CrossRef]
    [Google Scholar]
  13. Mulcahy, E. R., Bartz, J. C., Kincaid, A. E. & Bessen, R. A. ( 2004; ). Prion infection of skeletal muscle cells and papillae in the tongue. J Virol 78, 6792–6798.[CrossRef]
    [Google Scholar]
  14. Pattison, I. H. & Millson, G. C. ( 1962; ). Distribution of the scrapie agent in the tissues of experimentally inoculated goats. J Comp Pathol 72, 233–244.[CrossRef]
    [Google Scholar]
  15. Thomzig, A., Kratzel, C., Lenz, G., Krüger, D. & Beekes, M. ( 2003; ). Widespread PrPSc accumulation in muscles of hamsters orally infected with scrapie. EMBO Rep 4, 530–533.[CrossRef]
    [Google Scholar]
  16. Thomzig, A., Schulz-Schaeffer, W., Kratzel, C., Mai, J. & Beekes, M. ( 2004a; ). Preclinical deposition of pathological prion protein PrPSc in muscles of hamsters orally exposed to scrapie. J Clin Invest 113, 1465–1472.[CrossRef]
    [Google Scholar]
  17. Thomzig, A., Spassov, S., Friedrich, M., Naumann, D. & Beekes, M. ( 2004b; ). Discriminating scrapie and bovine spongiform encephalopathy isolates by infrared spectroscopy of pathological prion protein. J Biol Chem 279, 33847–33854.[CrossRef]
    [Google Scholar]
  18. van Keulen, L. J. M., Schreuder, B. E., Vromans, M. E. W., Langeveld, J. P. & Smits, M. A. ( 2000; ). Pathogenesis of natural scrapie in sheep. Arch Virol 16, 57–71.
    [Google Scholar]
  19. van Keulen, L. J. M., Vromans, M. E. W. & van Zijderveld, F. G. ( 2002; ). Early and late pathogenesis of natural scrapie in sheep. APMIS 110, 23–32.[CrossRef]
    [Google Scholar]
  20. White, A. R., Enever, P., Tayebi, M., Mushens, R., Linehan, J., Brandner, S., Anstee, D., Collinge, J. & Hawke, S. ( 2003; ). Monoclonal antibodies inhibit prion replication and delay the development of prion disease. Nature 422, 80–83.[CrossRef]
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jgv/10.1099/vir.0.81277-0
Loading
/content/journal/jgv/10.1099/vir.0.81277-0
Loading

Data & Media loading...

Most Cited This Month

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error