1887

Abstract

Since early 2007, the Kingdom of Saudi Arabia (KSA) has experienced several highly pathogenic avian influenza (HPAI) H5N1 outbreaks in the falconry and poultry sectors. The public health threat associated with peculiar husbandry systems, requiring close contact between humans and birds of prey, highlights the need of an improved understanding of the epidemiology and of the viral characteristics of H5N1 viruses circulating in the region. Here we report molecular and phylogenetic analyses of H5N1 viruses isolated in the KSA in 2007 in distinct compartments of avian husbandry. From the results of our investigation it appears that two separate introductions into the different sectors occurred. The identification of specific amino acid mutations, which are described as genetic signatures of human influenza A viruses or known to confer resistance to antiviral drugs, raises concerns for the possible human health implications of the KSA H5N1 viruses.

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2008-11-01
2021-02-28
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References

  1. Aamir U. B., Wernery U., Ilyushina N., Webster R. G. 2007; Characterization of avian H9N2 influenza viruses from United Arab Emirates 2000 to 2003. Virology 361:45–55 [CrossRef]
    [Google Scholar]
  2. Alexander D. J. 2007; Summary of avian influenza activity in Europe, Asia, Africa and Australasia, 2002–2006. Avian Dis 51:161–166 [CrossRef]
    [Google Scholar]
  3. Alexander D. J., Spackman D. 1981; Characterisation of influenza A viruses isolated from turkeys in England during March-May 1979. Avian Pathol 10:281–293 [CrossRef]
    [Google Scholar]
  4. Bailey T., Launay F., Sullivan T. 2000; Health issues of the international trade of falcons and bustards in the Middle East: the need for regional monitoring and regulation?. In Proceedings of the II International Conference on the Saker Falcon and Houbara Bustard Ulaanbaatar, Mongolia: pp 185–195 (in Russian) http://www.ead.ae/TacSoft/FileManager/Publications/reports/NARC/microchips.pdf
    [Google Scholar]
  5. Chen G. W., Chang S. C., Mok C. K., Lo Y. L., Kung Y. N., Huang J. H., Shih Y. H., Wang J. Y., Chiang C. other authors 2006; Genomic signatures of human versus avian influenza A viruses. Emerg Infect Dis 12:1353–1360 [CrossRef]
    [Google Scholar]
  6. Cheung C. L., Rayner J. M., Smith G. J. D., Wang P., Naipospos T. S. P., Zhang J., Yuen K. Y., Webster R. G., Peiris H. S. M. other authors 2006; Distribution of amantadine-resistant H5N1 avian influenza variants in Asia. J Infect Dis 193:1626–1629 [CrossRef]
    [Google Scholar]
  7. European Commission 2006; Council directive 2005/94/EC of December 20, 2005 on Community measures for the control of avian influenza and repealing Directive 92/40/EEC. Official Journal of the European Union L010:16–65 http://eur-lex.europa.eu/LexUriServ/LexUriServ.do?uri=OJ:L:2006:010:0016:0065:EN:PDF
    [Google Scholar]
  8. Fasina F. O., Bisschop S. P., Webster R. G. 2007; Avian influenza H5N1 in Africa: an epidemiological twist. Lancet Infect Dis 7:696–697 [CrossRef]
    [Google Scholar]
  9. Felsenstein J. 1989; phylip – phylogeny inference package (version 3.2. Cladistics 5:164–166
    [Google Scholar]
  10. Finkelstein D. B., Mukatira S., Mehta P. K., Obenauer J. C., Su X., Webster R. G., Naeve C. W. 2007; Persistent host markers in pandemic and H5N1 influenza viruses. J Virol 81:10292–10299 [CrossRef]
    [Google Scholar]
  11. Gaidet N., Dodman T., Caron A., Balança G., Desvaux S., Goutard F., Cattoli G., Lamarque F., Hagemeijer W., Monicat F. 2007; Avian influenza viruses in water birds, Africa. Emerg Infect Dis 13:626–629 [CrossRef]
    [Google Scholar]
  12. Ilyushina N. A., Govorkova E. A., Webster R. G. 2005; Detection of amantadine-resistant variants among avian influenza viruses isolated in North America and Asia. Virology 341:102–106 [CrossRef]
    [Google Scholar]
  13. Jackson D., Hossain M. J., Hickman D., Perez D. R., Lamb R. A. 2008; A new influenza virus virulence determinant: the NS1 protein four C-terminal residues modulate pathogenicity. Proc Natl Acad Sci U S A 105:4381–4386 [CrossRef]
    [Google Scholar]
  14. Kumar S., Tamura K., Nei M. 2004; mega3: integrated software for molecular evolutionary analysis and sequence alignment. Brief Bioinform 5:150–163 [CrossRef]
    [Google Scholar]
  15. Le Gall-Reculé G., Briand F. X., Schmitz A., Guionie O., Massin P., Jestin V. 2008; Double introduction of highly pathogenic H5N1 avian influenza virus into France in early 2006. Avian Pathol 37:15–23 [CrossRef]
    [Google Scholar]
  16. Lierz M., Hafez H. M., Klopfleisch R., Lüschow D., Prusas C., Teifke J. P., Rudolf M., Grund C., Kalthoff D. other authors 2007; Protection and virus shedding of falcons vaccinated against highly pathogenic avian influenza A virus (H5N1. Emerg Infect Dis 13:1667–1674 [CrossRef]
    [Google Scholar]
  17. Matrosovich M. N., Gambaryan A. S., Teneberg S., Piskarev V. E., Yamnikova S. S., Lvov D. K., Robertson J. S., Karlsson K. A. 1997; Avian influenza A viruses differ from human viruses by recognition of sialyloligosaccharides and gangliosides and by a higher conservation of the HA receptor-binding site. Virology 233:224–234 [CrossRef]
    [Google Scholar]
  18. Monne I., Cattoli G., Mazzacan E., Amarin N. M., Al Maaitah H. M., Al-Natour M. Q., Capua I. 2007; Genetic comparison of H9N2 AI viruses isolated in Jordan in 2003. Avian Dis 51:451–454 [CrossRef]
    [Google Scholar]
  19. Monne I., Joannis T. M., Fusaro A., De Benedictis P., Lombin L. H., Ularamu H., Egbuji A., Solomon P., Cattoli G., Capua I. 2008; Reassortant avian influenza virus (H5N1) in poultry. Nigeria: 2007 Emerg Infect Dis 14:637–640 [CrossRef]
    [Google Scholar]
  20. Obenauer J. C., Denson J., Mehta P. K., Su X., Mukatira S., Finkelstein D. B., Xu X., Wang J., Ma J. other authors 2006; Large-scale sequence analysis of avian influenza isolates. Science 311:1576–1580 [CrossRef]
    [Google Scholar]
  21. OIE 2005 Manual of Diagnostic Tests and Vaccines for Terrestrial Animals vol I and II, 5th edn. Paris: Office International des Epizooties; http://www.oie.int/eng/normes/mmanual/a_summry.htm
    [Google Scholar]
  22. OIE 2008 Update on highly pathogenic avian influenza in animals Office International des Epizooties; http://www.oie.int/downld/AVIAN%20INFLUENZA/A_AI-Asia.htm
    [Google Scholar]
  23. Pittman M., Laddomada A. 2008; Legislation for the control of avian influenza in the European Union. Zoonoses Public Health 55:29–36 [CrossRef]
    [Google Scholar]
  24. ProMED-mail 2006; Avian Influenza – Eurasia (39): Saudi Arabia, falcon. ProMED-mail 2006, 1 Feb: 20060201.0325 http://www.promedmail.org
  25. Salzberg S. L., Kingsford C., Cattoli G., Spiro D. J., Janies D. A., Aly M. M., Brown I. H., Couacy-Hymann E., De Mia G. M. other authors 2007; Genome analysis linking recent European and African influenza (H5N1) viruses. Emerg Infect Dis 13:713–718 [CrossRef]
    [Google Scholar]
  26. Sheng M., Sala C. 2001; PDZ domains and the organization of supramolecular complexes. Annu Rev Neurosci 24:1–29 [CrossRef]
    [Google Scholar]
  27. Starick E., Beer M., Hoffmann B., Staubach C., Werner O., Globig A., Strebelow G., Grund C., Durban M. other authors 2008; Phylogenetic analyses of highly pathogenic avian influenza virus isolates from Germany in 2006 and 2007 suggest at least three separate introductions of H5N1 virus. Vet Microbiol 128:243–252 [CrossRef]
    [Google Scholar]
  28. Subbarao E. K., London W., Murphy B. R. 1993; A single amino acid in the PB2 gene of influenza A virus is a determinant of host range. J Virol 67:1761–1764
    [Google Scholar]
  29. Suzuki H., Saito R., Masuda H., Oshitani H., Sato M., Satu I. 2003; Emergence of amantadine-resistant influenza A viruses: epidemiological study. J Infect Chemother 9:195–200 [CrossRef]
    [Google Scholar]
  30. WHO/OIE/FAO H5N1 Evolution working group 2008; Towards a unified nomenclature system for the highly pathogenic avian influenza H5N1 viruses. Emerg Infect Dis 14:e1
    [Google Scholar]
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