1887

Abstract

Human endogenous retroviruses (HERVs) make up a substantial part of the human genome. HERVs and solitary long terminal repeats (solo LTRs) are usually flanked by 4–6 nt short direct repeats through the well-known mechanism of their integration. A number of solo LTRs flanked by unusually long direct repeats were detected in the human genome. These unusual structures might be a product of an alternative virus insertion mechanism.

Loading

Article metrics loading...

/content/journal/jgv/10.1099/vir.0.19717-0
2004-06-01
2019-10-15
Loading full text...

Full text loading...

/deliver/fulltext/jgv/85/6/vir851485.html?itemId=/content/journal/jgv/10.1099/vir.0.19717-0&mimeType=html&fmt=ahah

References

  1. Chen, J. H., Hsieh, Y. Y., Hsiau, S. L., Lo, T. C. & Shau, C. C. ( 1999; ). Characterization of insertions of IS476 and two newly identified insertion sequences, IS1478 and IS1479, in Xanthomonas campestris pv. campestris. J Bacteriol 181, 1220–1228.
    [Google Scholar]
  2. Feng, Q., Moran, J. V., Kazazian, H. H., Jr & Boeke, J. D. ( 1996; ). Human L1 retrotransposon encodes a conserved endonuclease required for retrotransposition. Cell 87, 905–916.[CrossRef]
    [Google Scholar]
  3. International Human Genome Sequencing Consortium ( 2001; ). Initial sequencing and analysis of the human genome. Nature 409, 860–921.[CrossRef]
    [Google Scholar]
  4. Lebedev, Y. B., Belonovitch, O. S., Zybrova, N. V., Khil, P. P., Kurdyukov, S. G., Vinogradova, T. V., Hunsmann, G. & Sverdlov, E. D. ( 2000; ). Differences in HERV-K LTR insertions in orthologous loci of humans and great apes. Gene 247, 265–277.[CrossRef]
    [Google Scholar]
  5. Lower, R., Lower, J. & Kurth, R. ( 1996; ). The viruses in all of us: characteristics and biological significance of human endogenous retrovirus sequences. Proc Natl Acad Sci U S A 93, 5177–5184.[CrossRef]
    [Google Scholar]
  6. Mager, D. & Medstrand, P. ( 2002; ). Retroviral repeat sequences. In Encyclopedia of the Human Genome. Edited by K. Gardiner. London: Nature Publishing Group. Available at http://www.ehgonline.net/
  7. Mamedov, I., Batrak, A., Buzdin, A., Arzumanyan, E., Lebedev, Y. & Sverdlov, E. D. ( 2002; ). Genome-wide comparison of differences in the integration sites of interspersed repeats between closely related genomes. Nucleic Acids Res 30, e71.[CrossRef]
    [Google Scholar]
  8. Medstrand, P., van de Lagemaat, L. N. & Mager, D. L. ( 2002; ). Retroelement distributions in the human genome: variations associated with age and proximity to genes. Genome Res 12, 1483–1495.[CrossRef]
    [Google Scholar]
  9. Morrish, T. A., Gilbert, N., Myers, J. S., Vincent, B. J., Stamato, T. D., Taccioli, G. E., Batzer, M. A. & Moran, J. V. ( 2002; ). DNA repair mediated by endonuclease-independent LINE-1 retrotransposition. Nat Genet 31, 159–165.[CrossRef]
    [Google Scholar]
  10. Sverdlov, E. D. ( 1998; ). Perpetually mobile footprints of ancient infections in human genome. FEBS Lett 428, 1–6.[CrossRef]
    [Google Scholar]
  11. Sverdlov, E. D. ( 2000; ). Retroviruses and primate evolution. Bioessays 22, 161–171.[CrossRef]
    [Google Scholar]
  12. Tanaka, I. & Ishihara, H. ( 1995; ). Unusual long target duplication by insertion of intracisternal A-particle element in radiation-induced acute myeloid leukemia cells in mouse. FEBS Lett 376, 146–150.[CrossRef]
    [Google Scholar]
  13. Wilkinson, D. A., Mager, D. L. & Leong, J. C. ( 1994; ). Endogenous human retroviruses. In The Retroviridae, vol. 3. Edited by J. A. Levy. New York: Plenum.
http://instance.metastore.ingenta.com/content/journal/jgv/10.1099/vir.0.19717-0
Loading
/content/journal/jgv/10.1099/vir.0.19717-0
Loading

Data & Media loading...

Most Cited This Month

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error