1887

Abstract

A serological survey for human T cell leukaemia virus (HTLV)/simian T cell leukaemia virus (STLV) antibodies was performed in 61 wild-caught African apes, including five gorillas and 56 chimpanzees originating from south Cameroon. Two young animals, a gorilla () and a chimpanzee (), exhibited a pattern of complete HTLV-I seroreactivity. Sequence comparison and phylogenetic analyses using the complete LTR (750 bp) and a 522 bp fragment of the gene indicated the existence of two novel STLV-I strains, both of which belonged to HTLV-I/STLV-I molecular clade subtype B, specific to central Africa. These first STLV-I strains to be characterized in gorilla and chimpanzee were closely related to each other as well as to several HTLV-I strains originating from inhabitants of south Cameroon, including pygmies. Such findings reinforce the hypothesis of interspecies transmission of STLV-I to humans, leading to the present day distribution of HTLV-I in central African inhabitants.

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2004-01-01
2020-01-20
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References

  1. Blakeslee, J. R., Jr, McClure, H. M., Anderson, D. C., Bauer, R. M., Huff, L. Y. & Olsen, R. G. ( 1987; ). Chronic fatal disease in gorillas seropositive for simian T-lymphotropic virus I antibodies. Cancer Lett 37, 1–6.[CrossRef]
    [Google Scholar]
  2. Gessain, A., Gallo, R. C. & Franchini, G. ( 1992; ). Low degree of human T-cell leukemia/lymphoma virus type I genetic drift in vivo as a means of monitoring viral transmission and movement of ancient human populations. J Virol 66, 2288–2295.
    [Google Scholar]
  3. Guo, H. G., Wong-Stall, F. & Gallo, R. C. ( 1984; ). Novel viral sequences related to human T-cell leukemia virus in T cells of a seropositive baboon. Science 223, 1195–1197.[CrossRef]
    [Google Scholar]
  4. Ibrahim, F., de The, G. & Gessain, A. ( 1995; ). Isolation and characterization of a new simian T-cell leukemia virus type 1 from naturally infected celebes macaques (Macaca tonkeana): complete nucleotide sequence and phylogenetic relationship with the Australo-Melanesian human T-cell leukemia virus type 1. J Virol 69, 6980–6993.
    [Google Scholar]
  5. Ishikawa, K., Fukasawa, M., Tsujimoto, H. & 8 other authors ( 1987; ). Serological survey and virus isolation of simian T-cell leukemia/T-lymphotropic virus type I (STLV-I) in non-human primates in their native countries. Int J Cancer 40, 233–239.[CrossRef]
    [Google Scholar]
  6. Koralnik, I. J., Boeri, E., Saxinger, W. C. & 8 other authors ( 1994; ). Phylogenetic associations of human and simian T-cell leukemia/lymphotropic virus type I strains: evidence for interspecies transmission. J Virol 68, 2693–2707.
    [Google Scholar]
  7. Leendertz, F. H., Boesch, C., Junglen, S., Pauli, G. & Ellerbrook, H. ( 2003; ). Characterization of a new simian T-lymphocyte virus type 1 (STLV-1) in a wild living chimpanzee (Pan troglodytes verus) from Ivory Coast: evidence of a new STLV-I group? AIDS Res Hum Retroviruses 19, 255–258.[CrossRef]
    [Google Scholar]
  8. Mahieux, R., Ibrahim, F., Mauclere, P. & 11 other authors ( 1997; ). Molecular epidemiology of 58 new African human T-cell leukemia virus type 1 (HTLV-1) strains: identification of a new and distinct HTLV-I molecular subtype in Central Africa and in Pygmies. J Virol 71, 1317–1333.
    [Google Scholar]
  9. Mahieux, R., Chappey, C., Georges-Courbot, M. C., Dubreuil, G., Mauclere, P., Georges, A. & Gessain, A. ( 1998; ). Simian T-cell lymphotropic virus type 1 from Mandrillus sphinx as a simian counterpart of human T-cell lymphotropic virus type 1 subtype D. J Virol 72, 10316–10322.
    [Google Scholar]
  10. Meertens, L., Rigoulet, J., Mauclere, P. & 8 other authors ( 2001; ). Molecular and phylogenetic analyses of 16 novel simian T cell leukemia virus type 1 from Africa: close relationship of STLV-1 from Allenopithecus nigroviridis to HTLV-I subtype B strains. Virology 287, 275–285.[CrossRef]
    [Google Scholar]
  11. Miyoshi, I., Yoshimoto, S., Fujishita, M., Taguchi, H., Kubonishi, I., Niiya, K. & Minezawa, M. ( 1982; ). Natural adult T-cell leukemia virus infection in Japanese monkeys. Lancet 2, 658.
    [Google Scholar]
  12. Nerrienet, E., Meertens, L., Kfutwah, A., Foupouapouognigni, Y. & Gessain, A. ( 2001; ). Molecular epidemiology of simian T-lymphotropic virus (STLV) in wild-caught monkeys and apes from Cameroon: a new STLV-1, related to human T-lymphotropic virus subtype F, in a Cercocebus agilis. J Gen Virol 82, 2973–2977.
    [Google Scholar]
  13. Niphuis, H., Verschoor, E. J., Bontjer, I., Peeters, M. & Heeney, J. L. ( 2003; ). Reduced transmission and prevalence of simian T-cell lymphotropic virus in a closed breeding colony of chimpanzees (Pan troglodytes verus). J Gen Virol 84, 615–620.[CrossRef]
    [Google Scholar]
  14. Saksena, N. K., Herve, V., Durand, J. P. & 8 other authors ( 1994; ). Seroepidemiologic, molecular, and phylogenetic analyses of simian T-cell leukemia viruses (STLV-I) from various naturally infected monkey species from central and western Africa. Virology 198, 297–310.[CrossRef]
    [Google Scholar]
  15. Salemi, M., Van Dooren, S., Audenaert, E., Delaporte, E., Goubau, P., Desmyter, J. & Vandamme, A. M. ( 1998; ). Two new human T-lymphotropic virus type I phylogenetic subtypes in seroindeterminates, a Mbuti pygmy and a Gabonese, have closest relatives among African STLV-I strains. Virology 246, 277–287.[CrossRef]
    [Google Scholar]
  16. Salemi, M., Desmyter, J. & Vandamme, A. M. ( 2000; ). Tempo and mode of human and simian T-lymphotropic virus (HTLV/STLV) evolution revealed by analyses of full-genome sequences. Mol Biol Evol 17, 374–386.[CrossRef]
    [Google Scholar]
  17. Santiago, M. L., Rodenburg, C. M., Kamenya, S. & 21 other authors ( 2002; ). SIVcpz in wild chimpanzees. Science 295, 465.[CrossRef]
    [Google Scholar]
  18. Slattery, J. P., Franchini, G. & Gessain, A. ( 1999; ). Genomic evolution, patterns of global dissemination, and interspecies transmission of human and simian T-cell leukemia/lymphotropic viruses. Genome Res 9, 525–540.
    [Google Scholar]
  19. Srivastava, B. I., Wong-Staal, F. & Getchell, J. P. ( 1986; ). Human T-cell leukemia virus I provirus and antibodies in a captive gorilla with non-Hodgkin's lymphoma. Cancer Res 46, 4756–4758.
    [Google Scholar]
  20. Van Dooren, S., Salemi, M. & Vandamme, A. M. ( 2001; ). Dating the origin of the African human T-cell lymphotropic virus type-I (HTLV-I) subtypes. Mol Biol Evol 18, 661–671.[CrossRef]
    [Google Scholar]
  21. Vandamme, A. M., Salemi, M. & Desmyter, J. ( 1998; ). The simian origins of the pathogenic human T-cell lymphotropic virus type I. Trends Microbiol 6, 477–483.[CrossRef]
    [Google Scholar]
  22. Voevodin, A. F., Johnson, B. K., Samilchuk, E. I., Stone, G. A., Druilhet, R., Greer, W. J. & Gibbs, C. J., Jr, ( 1997; ). Phylogenetic analysis of simian T-lymphotropic virus type I (STLV-I) in common chimpanzees (Pan troglodytes): evidence for interspecies transmission of the virus between chimpanzees and humans in Central Africa. Virology 238, 212–220.[CrossRef]
    [Google Scholar]
  23. Watanabe, T., Seiki, M., Tsujimoto, H., Miyoshi, I., Hayami, M. & Yoshida, M. ( 1985; ). Sequence homology of the simian retrovirus genome with human T-cell leukemia virus type I. Virology 144, 59–65.[CrossRef]
    [Google Scholar]
  24. Watanabe, T., Seiki, M., Hirayama, Y. & Yoshida, M. ( 1986; ). Human T-cell leukemia virus type I is a member of the African subtype of simian viruses (STLV). Virology 148, 385–388.[CrossRef]
    [Google Scholar]
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