1887

Abstract

Interferons (IFNs) are important mediators of antiviral activity. In this study we have investigated how production of IFN- is induced during herpes simplex virus type 2 (HSV-2) infection in murine peritoneal cells (PCs). We found that HSV-2 infection of thioglycolate-activated PCs from BALB/c mice rapidly led to expression of type 1 IFNs (IFN-/) and interleukin (IL)-12, which was followed by production of IFN-. IL-12 alone induced the most expression of IFN-, which was augmented by cotreatment with IFN- or IL-18, or combinations of IFN- and IL-18. Moreover, neutralization of any of these cytokines strongly reduced the production of IFN-, and neutralization of all three cytokines totally prevented HSV-2-induced IFN- expression. Our data suggest that IFN- production is induced during HSV-2 infection through the coordinated action of IFN-/, IL-12 and IL-18.

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2003-09-01
2020-08-06
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References

  1. Boehm U., Klamp T., Groot M., Howard J. C.. 1997; Cellular responses to interferon- γ . Annu Rev Immunol15:749–795
    [Google Scholar]
  2. Carson W. E., Ross M. E., Baiocchi R. A., Marien M. J., Boiani N., Grabstein K., Caligiuri M. A.. 1995; Endogenous production of interleukin 15 by activated human monocytes is critical for optimal production of interferon-gamma by natural killer cells in vitro. J Clin Invest96:2578–2582
    [Google Scholar]
  3. Cousens L. P., Orange J. S., Su H. C., Biron C. A.. 1997; Interferon- α / β inhibition of interleukin 12 and interferon- γ production in vitro and endogenously during viral infection. Proc Natl Acad Sci U S A94:634–639
    [Google Scholar]
  4. Ellermann-Eriksen S.. 1993; Autocrine secretion of interferon-alpha/beta and tumour necrosis factor-alpha synergistically activates mouse macrophages after infection with herpes simplex virus type 2. J Gen Virol74:2191–2199
    [Google Scholar]
  5. Harandi A. M., Svennerholm B., Holmgren J., Eriksson K.. 2001; Interleukin-12 (IL-12) and IL-18 are important in innate defense against genital herpes simplex virus type 2 infection in mice but are not required for the development of acquired gamma interferon-mediated protective immunity. J Virol75:6705–6709
    [Google Scholar]
  6. Kodukula P., Liu T., van Rooijen N., Jager M. J., Hendricks R. L.. 1999; Macrophage control of herpes simplex virus type 1 replication in the peripheral nervous system. J Immunol162:2895–2905
    [Google Scholar]
  7. Lankford C. S. R., Frught D. M.. 2003; A unique role for IL-23 in promoting cellular immunity. J Leukoc Biol73:49–56
    [Google Scholar]
  8. Malmgaard L., Paludan S. R., Mogensen S. C., Ellermann-Eriksen S.. 2000; Herpes simplex virus type 2 induces interleukin-12 in macrophages through a mechanism involving NF- κ B. J Gen Virol81:3011–3020
    [Google Scholar]
  9. Malmgaard L., Salazar-Mather T. P., Lewis C. A., Biron C. A.. 2002; Promotion of alpha/beta interferon induction during in vivo viral infection through alpha/beta interferon receptor/STAT1 system-dependent and -independent pathways. J Virol76:4520–4525
    [Google Scholar]
  10. Mikloska Z., Cunningham A. L.. 2001; Alpha and gamma interferons inhibit herpes simplex virus type 1 infection and spread in epidermal cells after axonal transmission. J Virol75:11821–11826
    [Google Scholar]
  11. Muller U., Steinhoff U., Reis L. F., Hemmi S., Pavlovic J., Zinkernagel R. M., Aguet M.. 1994; Functional role of type I and type II interferons in antiviral defense. Science264:1918–1921
    [Google Scholar]
  12. Nakamura K., Okamura H., Wada M., Nagata K., Tamura T.. 1989; Endotoxin-induced serum factor that stimulates gamma interferon production. Infect Immun57:590–595
    [Google Scholar]
  13. Nguyen K. B., Watford W. T., Salomon R., Hofmann S. R., Pien G. C., Morinobu A., Gadina M., O'Shea J. J., Biron C. A.. 2002; Critical role for STAT4 activation by type 1 interferons in the interferon- γ response to viral infection. Science297:2063–2066
    [Google Scholar]
  14. Okamura H., Kashiwamura S., Tsutsui H., Yoshimoto T., Nakanishi K.. 1998; Regulation of interferon-gamma production by IL-12 and IL-18. Curr Opin Immunol10:259–264
    [Google Scholar]
  15. Oppmann B., Lesley R., Blom B.. 22 other authors 2000; Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12. Immunity13:715–725
    [Google Scholar]
  16. Orange J. S., Biron C. A.. 1996; Characterization of early IL-12, IFN-alpha/beta and TNF effects on antiviral state and NK cell responses during murine cytomegalovirus infection. J Immunol156:4746–4756
    [Google Scholar]
  17. Paludan S. R., Ellermann-Eriksen S., Mogensen S. C.. 1998; NF-kappaB activation is responsible for the synergistic effect of herpes simplex virus type 2 infection on interferon-gamma-induced nitric oxide production. J Gen Virol79:2785–2793
    [Google Scholar]
  18. Paludan S. R., Melchjorsen J., Malmgaard L., Mogensen S. C.. 2002; Expression of genes for cytokines and cytokine-related functions in leukocytes infected with herpes simplex virus: comparison between resistant and susceptible mouse strains. Eur Cytokine Netw13:306–316
    [Google Scholar]
  19. Pflanz S., Timans J. C., Cheung J.. 18 other authors 2002; IL-27, a heterodimeric cytokine composed of EBI3 and p28 protein, induces proliferation of naive CD4+ T cells. Immunity16:779–790
    [Google Scholar]
  20. Pien G. C., Satoskar A. R., Takeda K., Akira S., Biron C. A.. 2000; Selective IL-18 requirements for induction of compartmental IFN- γ responses during viral infection. J Immunol165:4787–4791
    [Google Scholar]
  21. Pien G. C., Nguyen K. B., Malmgaard L., Satoskar A. R., Biron C. A.. 2002; A unique mechanism for innate cytokine promotion of T cell responses to viral infections. J Immunol169:5827–5837
    [Google Scholar]
  22. Salazar-Mather T. P., Lewis C. A., Biron C. A.. 2002; Type I interferons regulate inflammatory cell trafficking and macrophage inflammatory protein 1 α delivery to the liver. J Clin Invest110:321–330
    [Google Scholar]
  23. Sareneva T., Matikainen S., Kurimoto M., Julkunen I.. 1998; Influenza A virus-induced IFN- α / β and IL-18 synergistically enhance IFN- γ gene expression in human T cells. J Immunol160:6032–6038
    [Google Scholar]
  24. Stark G. R., Kerr I. M., Williams B. R., Silverman R. H., Schreiber R. D.. 1998; How cells respond to interferons. Annu Rev Biochem67:227–264
    [Google Scholar]
  25. Whitley R. J.. 2001; Herpes simplex virus. In Fields Virology pp 2461–2509 Edited by Knipe D. M., Howley P. M.. Philadelphia: Lippincott Williams & Wilkins;
    [Google Scholar]
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