1887

Abstract

It was demonstrated using self-replicating hepatitis C virus (HCV) RNAs that both types of interferons (IFNs) (in particular IFN- and IFN-) are potent inhibitors of HCV replication in Huh-7 cells. Because IFN- and tumour necrosis factor (TNF)- trigger a partially overlapping set of antiviral defence mechanisms, it is tempting to speculate that TNF- also inhibits HCV replication. However, this study shows that TNF- does not affect HCV protein and RNA synthesis, nor does it synergistically enhance the inhibitory effect of IFN-. Taken together, these results demonstrate that HCV replication in Huh-7 cells is highly resistant to TNF-. It is, therefore, unlikely that the increased production of TNF-, which is seen in many hepatitis C patients, contributes to HCV clearance by inducing antiviral defence mechanisms in infected hepatocytes.

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2003-05-01
2019-10-18
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