1887

Abstract

Enhancement of flavivirus infection in the presence of subneutralizing concentrations of homologous or heterologous antiserum has been well described. However, the importance of this phenomenon in the enhancement of flavivirus infection has not been established. In order to study antibody-mediated enhancement of flavivirus infection , we investigated the effect of passive immunization of mice with Japanese encephalitis virus (JE) antiserum on the outcome of infection with Murray Valley encephalitis virus (MVE). We show that prior treatment of mice with subneutralizing concentrations of heterologous JE antiserum resulted in an increase in viraemia titres and in mortality following challenge with wild-type MVE. Our findings support the hypothesis that subneutralizing concentrations of antibody may enhance flavivirus infection and virulence . These findings are of potential importance for the design of JE vaccination programs in geographic areas in which MVE co-circulates. Should subneutralizing concentrations of antibody remain in the population following JE vaccination, it is possible that enhanced disease may be observed during MVE epidemics.

Loading

Article metrics loading...

/content/journal/jgv/10.1099/vir.0.18980-0
2003-07-01
2020-01-26
Loading full text...

Full text loading...

/deliver/fulltext/jgv/84/7/vir841723.html?itemId=/content/journal/jgv/10.1099/vir.0.18980-0&mimeType=html&fmt=ahah

References

  1. Bourke, D. & Monath, T. ( 2001; ). Flaviviruses. In Fields Virology, 4th edn, vol. 1, pp 1043–1126. Edited by D. M. Knipe & P. M. Howley. Philadelphia: Lippincott Williams & Wilkins.
  2. Broom, A. K., Wallace, M. J., Mackenzie, J. S., Smith, D. W. & Hall, R. A. ( 2000; ). Immunization with gamma globulin to Murray Valley encephalitis virus and with an inactivated Japanese encephalitis virus vaccine as prophylaxis against Australian encephalitis: evaluation in a mouse model. J Med Virol 61, 259–265.[CrossRef]
    [Google Scholar]
  3. Calisher, C. H., Karabatsos, N., Dalrymple, J. M., Shope, R. E., Porterfield, J. S., Westaway, E. G. & Brandt, W. E. ( 1989; ). Antigenic relationships between flaviviruses as determined by cross-neutralization tests with polyvalent antisera. J Gen Virol 70, 37–43.[CrossRef]
    [Google Scholar]
  4. French, E. ( 1952; ). Murray Valley encephalitis: isolation and characterization of the aetiological agent. Medical J Australia 1, 100–103.
    [Google Scholar]
  5. Gollins, S. & Porterfield, J. ( 1984; ). Flavivirus infection enhancement in macrophages: radioactive and biological studies on the effect of antibody on viral fate. J Gen Virol 65, 1261–1272.[CrossRef]
    [Google Scholar]
  6. Hall, R. A., Broom, A. K., Hartnett, A. C., Howard, M. J. & Mackenzie, J. S. ( 1995; ). Immunodominant epitopes on the NS1 protein of MVE and KUN viruses serve as targets for a blocking ELISA to detect virus-specific antibodies in sentinel animal serum. J Virol Methods 51, 201–210.[CrossRef]
    [Google Scholar]
  7. Halstead, S. ( 1988; ). Pathogenesis of dengue: challenges to molecular biology. Science 239, 476–481.[CrossRef]
    [Google Scholar]
  8. Halstead, S. ( 1989; ). Antibody, macrophages, dengue virus infection, shock and haemorrhage: a pathogenic cascade. Rev Infect Dis 11, S830–S839.[CrossRef]
    [Google Scholar]
  9. Halstead, S. & O'Rourke, E. ( 1977; ). Dengue viruses and mononuclear phagocytes. Infection enhancement by non-neutralizing antibody. J Exp Med 146, 201–217.[CrossRef]
    [Google Scholar]
  10. Halstead, S., Nimmannitya, S., Yamarat, C. & Russell, P. ( 1967; ). Haemorrhagic fever in Thailand: newer knowledge regarding etiology. Jpn J Med Sci Biol 20, 96–103.
    [Google Scholar]
  11. Halstead, S., Chow, J. & Marchette, N. ( 1973; ). Immunological enhancement of dengue virus replication. Nature New Biol 243, 24–26.
    [Google Scholar]
  12. Halstead, S., Marchette, N. & O'Rourke, E. ( 1978; ). Immunologically enhanced dengue virus infection of mononuclear phagocytes: a mechanism, which may regulate disease severity. Asian J Infect Dis 2, 85–93.
    [Google Scholar]
  13. Hanna, J. N., Ritchie, S. A., Phillips, D. A., Lee, J. M., Hills, S. L., van den Hurk, A. F., Pyke, A. T., Johansen, C. A. & Mackenzie, J. S. ( 1999; ). Japanese encephalitis in north Queensland, Australia, 1998. Med J Aust 170, 533–536.
    [Google Scholar]
  14. Hanna, J. N., Ritchie, S. A., Phillips, D. A. & 14 other authors ( 2000; ). Flaviviridae. In Virus Taxonomy. Seventh Report of the International Committee on Taxonomy of Viruses, pp. 859–878. Edited by M. H. V. van Regenmortel, C. M. Fauquet, D. H. L. Bishop, E. B. Carstens, M. K. Estes, S. M. Lemon, J. Maniloff, M. A. Mayo, D. J. McGeoch, C. R. Pringle & R. B. Wickner. San Diego: Academic Press.
  15. Hawkes, R. ( 1964; ). Enhancement of infectivity of arboviruses by specific antisera produced in domestic fowls. Aust J Exp Biol Med Sci 42, 465–482.[CrossRef]
    [Google Scholar]
  16. Kreil, T. & Eibl, M. ( 1997; ). Pre- and postexposure protection by passive immunoglobulin but no enhancement of infection with a flavivirus in a mouse model. J Virol 71, 2921–2927.
    [Google Scholar]
  17. Mackenzie, J. S., Lindsay, M. D., Coelen, R. J., Broom, A. K., Hall, R. A. & Smith, D. W. ( 1994; ). Arboviruses causing human disease in the Australasian zoogeographic region. Arch Virol 136, 447–467.[CrossRef]
    [Google Scholar]
  18. Mackenzie, J. S., Johansen, C. A., Ritchie, S. A., van den Hurk, A. F. & Hall, R. A. ( 2002; ). Japanese encephalitis as an emerging virus: the emergence and spread of Japanese encephalitis virus in Australasia. Curr Top Microbiol Immunol 267, 49–73.
    [Google Scholar]
  19. McMinn, P., Marshall, I. & Dalgarno, L. ( 1995; ). Neurovirulence and neuroinvasiveness of Murray Valley encephalitis virus mutants selected by passage in a monkey kidney cell line. J Gen Virol 76, 865–872.[CrossRef]
    [Google Scholar]
  20. Mitamura, T., Kitaoka, M., Watanabe, M. and others ( 1936; ). Study on Japanese encephalitis virus: animal experiments and mosquito transmission experiments. Kansai Ijo 1, 260.
    [Google Scholar]
  21. Mills, P. J. ( 1996; ). An outbreak of Japanese encephalitis in the Torres Strait, Australia, 1995. Med J Aust 165, 256–260.
    [Google Scholar]
  22. Morens, D. ( 1994; ). Antibody-dependent enhancement of infection and the pathogenesis of viral disease. Clin Infect Dis 19, 500–512.[CrossRef]
    [Google Scholar]
  23. Morens, D., Halstead, S. & Marchette, N. ( 1987; ). Profiles of antibody-dependent enhancement of dengue virus type 2 infection. Microb Pathog 3, 231–237.[CrossRef]
    [Google Scholar]
  24. Pyke, A., Williams, D., Nisbet, D. & 11 other authors ( 2001; ). The appearance of a second genotype of Japanese encephalitis virus in the Australasian region. Am J Trop Med Hyg 65, 747–753.
    [Google Scholar]
  25. Russell, P., Udomsakdi, S. & Halstead, S. ( 1967; ). Antibody response in dengue and dengue haemorrhagic fever. Jpn J Medical Science and Biology 20(suppl), 103–108.[CrossRef]
    [Google Scholar]
  26. Vaughn, D. & Hoke, C. ( 1992; ). The epidemiology of Japanese encephalitis: prospects for prevention. Epidemiol Rev 14, 197–221.
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jgv/10.1099/vir.0.18980-0
Loading
/content/journal/jgv/10.1099/vir.0.18980-0
Loading

Data & Media loading...

Most cited articles

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error