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Journal of General Virology header logo Journal of General Virology

Volume 95, Issue 12

Human herpesvirus 6 gM/gN complex interacts with v-SNARE in infected cells No Access

Abstract

Human herpesvirus 6 (HHV-6) glycoprotein M (gM) is an envelope glycoprotein that associates with glycoprotein N (gN), forming the gM/gN protein complex, in a similar manner to the other herpesviruses. Liquid chromatography-MS/MS analysis showed that the HHV-6 gM/gN complex interacts with the v-SNARE protein, vesicle-associated membrane protein 3 (VAMP3). VAMP3 colocalized with the gM/gN complex at the -Golgi network and other compartments, possibly the late endosome in HHV-6-infected cells, and its expression gradually increased during the late phase of virus infection. Finally, VAMP3 was incorporated into mature virions and may be transported with the gM/gN complex.

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© 2014 The Authors
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/content/journal/jgv/10.1099/vir.0.069336-0
2014-12-01
2025-06-21
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/content/journal/jgv/10.1099/vir.0.069336-0
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Human herpesvirus 6 gM/gN complex interacts with v-SNARE in infected cells
J. Gen. Virol. 95, 2769 (2014); https://doi.org/10.1099/vir.0.069336-0
/content/journal/jgv/10.1099/vir.0.069336-0
/content/journal/jgv/10.1099/vir.0.069336-0
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