1887

Abstract

The recent human outbreak of H7N9 avian influenza A virus has caused worldwide concerns. Receptor binding specificity is critical for viral pathogenicity, and still not thoroughly studied for this emerging virus. Here, we evaluated the receptor specificity of the haemagglutinin (HA) of two human H7N9 isolates (A/Shanghai/1/13 and A/Anhui/1/13) through a solid-phase binding assay and a flow cytometry-based assay. In addition, we compared it with those from several HAs from human and avian influenza viruses. We observed that the HAs from the novel H7 isolates strongly interacted with α2,3-linked sialic acids. Importantly, they also showed low levels of binding to α2,6-linked sialic acids, but significantly higher than other avian H7s.

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2013-11-01
2020-07-10
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References

  1. Belser J. A., Blixt O., Chen L. M., Pappas C., Maines T. R., Van Hoeven N., Donis R., Busch J., McBride R. other authors 2008; Contemporary North American influenza H7 viruses possess human receptor specificity: implications for virus transmissibility. Proc Natl Acad Sci U S A 105:7558–7563 [CrossRef][PubMed]
    [Google Scholar]
  2. Belser J. A., Gustin K. M., Pearce M. B., Maines T. R., Zeng H., Pappas C., Sun X., Carney P. J., Villanueva J. M. other authors 2013; Pathogenesis and transmission of avian influenza A (H7N9) virus in ferrets and mice. Nature [Epub ahead of print] [CrossRef][PubMed]
    [Google Scholar]
  3. Fodor E., Devenish L., Engelhardt O. G., Palese P., Brownlee G. G., García-Sastre A. 1999; Rescue of influenza A virus from recombinant DNA. J Virol 73:9679–9682[PubMed]
    [Google Scholar]
  4. Gao R., Cao B., Hu Y., Feng Z., Wang D., Hu W., Chen J., Jie Z., Qiu H. other authors 2013; Human infection with a novel avian-origin influenza A (H7N9) virus. N Engl J Med 368:1888–1897 [CrossRef][PubMed]
    [Google Scholar]
  5. Goff P. H., Krammer F., Hai R., Seibert C. W., Margine I., García-Sastre A., Palese P. 2013; Induction of cross-reactive antibodies to novel H7N9 influenza virus by recombinant Newcastle disease virus expressing a North American lineage H7 subtype hemagglutinin. J Virol 87:8235–8240 [CrossRef][PubMed]
    [Google Scholar]
  6. Guo C. T., Takahashi N., Yagi H., Kato K., Takahashi T., Yi S. Q., Chen Y., Ito T., Otsuki K. other authors 2007; The quail and chicken intestine have sialyl-galactose sugar chains responsible for the binding of influenza A viruses to human type receptors. Glycobiology 17:713–724 [CrossRef][PubMed]
    [Google Scholar]
  7. Han J., Jin M., Zhang P., Liu J., Wang L., Wen D., Wu X., Liu G., Zou Y. other authors 2013; Epidemiological link between exposure to poultry and all influenza A(H7N9) confirmed cases in Huzhou city, China, March to May 2013. Euro Surveill 18:20418[PubMed]
    [Google Scholar]
  8. Kageyama T., Fujisaki S., Takashita E., Xu H., Yamada S., Uchida Y., Neumann G., Saito T., Kawaoka Y., Tashiro M. 2013; Genetic analysis of novel avian A(H7N9) influenza viruses isolated from patients in China, February to April 2013. Euro Surveill 18:20453[PubMed]
    [Google Scholar]
  9. Krammer F., Margine I., Tan G. S., Pica N., Krause J. C., Palese P. 2012; A carboxy-terminal trimerization domain stabilizes conformational epitopes on the stalk domain of soluble recombinant hemagglutinin substrates. PLoS ONE 7:e43603 [CrossRef][PubMed]
    [Google Scholar]
  10. Kuiken T., Holmes E. C., McCauley J., Rimmelzwaan G. F., Williams C. S., Grenfell B. T. 2006; Host species barriers to influenza virus infections. Science 312:394–397 [CrossRef][PubMed]
    [Google Scholar]
  11. Matrosovich M. N., Krauss S., Webster R. G. 2001; H9N2 influenza A viruses from poultry in Asia have human virus-like receptor specificity. Virology 281:156–162 [CrossRef][PubMed]
    [Google Scholar]
  12. Matrosovich M. N., Matrosovich T. Y., Gray T., Roberts N. A., Klenk H. D. 2004; Human and avian influenza viruses target different cell types in cultures of human airway epithelium. Proc Natl Acad Sci U S A 101:4620–4624 [CrossRef][PubMed]
    [Google Scholar]
  13. Neumann G., Kawaoka Y. 2006; Host range restriction and pathogenicity in the context of influenza pandemic. Emerg Infect Dis 12:881–886 [CrossRef][PubMed]
    [Google Scholar]
  14. Nicholls J. M., Chan M. C., Chan W. Y., Wong H. K., Cheung C. Y., Kwong D. L., Wong M. P., Chui W. H., Poon L. L. other authors 2007; Tropism of avian influenza A (H5N1) in the upper and lower respiratory tract. Nat Med 13:147–149 [CrossRef][PubMed]
    [Google Scholar]
  15. Nidom C. A., Takano R., Yamada S., Sakai-Tagawa Y., Daulay S., Aswadi D., Suzuki T., Suzuki Y., Shinya K. other authors 2010; Influenza A (H5N1) viruses from pigs, Indonesia. Emerg Infect Dis 16:1515–1523 [CrossRef][PubMed]
    [Google Scholar]
  16. Pawar S. D., Parkhi S. S., Koratkar S. S., Mishra A. C. 2012; Receptor specificity and erythrocyte binding preferences of avian influenza viruses isolated from India. Virol J 9:251 [CrossRef][PubMed]
    [Google Scholar]
  17. Peiris J. S., de Jong M. D., Guan Y. 2007; Avian influenza virus (H5N1): a threat to human health. Clin Microbiol Rev 20:243–267 [CrossRef][PubMed]
    [Google Scholar]
  18. Pillai S. P., Lee C. W. 2010; Species and age related differences in the type and distribution of influenza virus receptors in different tissues of chickens, ducks and turkeys. Virol J 9:5 [CrossRef][PubMed]
    [Google Scholar]
  19. Ramos I., Bernal-Rubio D., Durham N., Belicha-Villanueva A., Lowen A. C., Steel J., Fernandez-Sesma A. 2011; Effects of receptor binding specificity of avian influenza virus on the human innate immune response. J Virol 85:4421–4431 [CrossRef][PubMed]
    [Google Scholar]
  20. Shinya K., Ebina M., Yamada S., Ono M., Kasai N., Kawaoka Y. 2006; Avian flu: influenza virus receptors in the human airway. Nature 440:435–436 [CrossRef][PubMed]
    [Google Scholar]
  21. Srinivasan K., Raman R., Jayaraman A., Viswanathan K., Sasisekharan R. 2013; Quantitative description of glycan-receptor binding of influenza a virus H7 hemagglutinin. PLoS ONE 8:e49597 [CrossRef][PubMed]
    [Google Scholar]
  22. Stevens J., Blixt O., Tumpey T. M., Taubenberger J. K., Paulson J. C., Wilson I. A. 2006; Structure and receptor specificity of the hemagglutinin from an H5N1 influenza virus. Science 312:404–410 [CrossRef][PubMed]
    [Google Scholar]
  23. Tan G. S., Krammer F., Eggink D., Kongchanagul A., Moran T. M., Palese P. 2012; A pan-H1 anti-hemagglutinin monoclonal antibody with potent broad-spectrum efficacy in vivo. J Virol 86:6179–6188 [CrossRef][PubMed]
    [Google Scholar]
  24. Tharakaraman K., Jayaraman A., Raman R., Viswanathan K., Stebbins N. W., Johnson D., Shriver Z., Sasisekharan V., Sasisekharan R. 2013; Glycan receptor binding of the influenza A virus H7N9 hemagglutinin. Cell 153:1486–1493 [CrossRef][PubMed]
    [Google Scholar]
  25. van Riel D., Munster V. J., de Wit E., Rimmelzwaan G. F., Fouchier R. A., Osterhaus A. D., Kuiken T. 2006; H5N1 virus attachment to lower respiratory tract. Science 312:399 [CrossRef][PubMed]
    [Google Scholar]
  26. Wan H., Perez D. R. 2006; Quail carry sialic acid receptors compatible with binding of avian and human influenza viruses. Virology 346:278–286 [CrossRef][PubMed]
    [Google Scholar]
  27. Wang W., Lu B., Zhou H., Suguitan A. L. Jr, Cheng X., Subbarao K., Kemble G., Jin H. 2010; Glycosylation at 158N of the hemagglutinin protein and receptor binding specificity synergistically affect the antigenicity and immunogenicity of a live attenuated H5N1 A/Vietnam/1203/2004 vaccine virus in ferrets. J Virol 84:6570–6577 [CrossRef][PubMed]
    [Google Scholar]
  28. Watanabe Y., Ibrahim M. S., Ellakany H. F., Kawashita N., Mizuike R., Hiramatsu H., Sriwilaijaroen N., Takagi T., Suzuki Y., Ikuta K. 2011; Acquisition of human-type receptor binding specificity by new H5N1 influenza virus sublineages during their emergence in birds in Egypt. PLoS Pathog 7:e1002068 [CrossRef][PubMed]
    [Google Scholar]
  29. Watanabe T., Kiso M., Fukuyama S., Nakajima N., Imai M., Yamada S., Murakami S., Yamayoshi S., Iwatsuki-Horimoto K. other authors 2013; Characterization of H7N9 influenza A viruses isolated from humans. Nature [Epub ahead of print] [CrossRef][PubMed]
    [Google Scholar]
  30. WHO 2013; WHO risk assessment. Human infections with avian influenza A(H7N9) virus. http://www.who.int/influenza/human_animal_interface/influenza_h7n9/RiskAssessment_H7N9_07Jun13.pdf
    [Google Scholar]
  31. Xiong X., Martin S. R., Haire L. F., Wharton S. A., Daniels R. S., Bennett M. S., McCauley J. W., Collins P. J., Walker P. A. other authors 2013; Receptor binding by an H7N9 influenza virus from humans. Nature 499:496–499 [CrossRef][PubMed]
    [Google Scholar]
  32. Xu C., Havers F., Wang L., Chen T., Shi J., Wang D., Yang J., Yang L., Widdowson M.-A., Shu Y. 2013; Monitoring avian influenza A(H7N9) virus through national influenza-like illness surveillance, China. Emerg Infect Dis 19496–499 [CrossRef]
    [Google Scholar]
  33. Yamada S., Suzuki Y., Suzuki T., Le M. Q., Nidom C. A., Sakai-Tagawa Y., Muramoto Y., Ito M., Kiso M. other authors 2006; Haemagglutinin mutations responsible for the binding of H5N1 influenza A viruses to human-type receptors. Nature 444:378–382 [CrossRef][PubMed]
    [Google Scholar]
  34. Yang H., Chen L. M., Carney P. J., Donis R. O., Stevens J. 2010; Structures of receptor complexes of a North American H7N2 influenza hemagglutinin with a loop deletion in the receptor binding site. PLoS Pathog 6:e1001081 [CrossRef][PubMed]
    [Google Scholar]
  35. Zhou J., Wang D., Gao R., Zhao B., Song J., Qi X., Zhang Y., Shi Y., Yang L. other authors 2013; Biological features of novel avian influenza A (H7N9) virus. Nature 499: [Epub ahead of print] [CrossRef][PubMed]
    [Google Scholar]
  36. Zhu H., Wang D., Kelvin D. J., Li L., Zheng Z., Yoon S. W., Wong S. S., Farooqui A., Wang J. other authors 2013; Infectivity, transmission, and pathology of human-isolated H7N9 influenza virus in ferrets and pigs. Science 341:183–186 [CrossRef][PubMed]
    [Google Scholar]
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