1887

Abstract

Porcine epidemic diarrhea virus (PEDV) causes severe diarrhea and even death in piglets, resulting in significant economic losses to the pig industry. Because of the ongoing mutation of PEDV, there might be variations between the vaccine strain and the prevailing strain, causing the vaccine to not offer full protection against different PEDV variant strains. Therefore, it is necessary to develop anti-PEDV drugs to compensate for vaccines. This study confirmed the anti-PEDV effect of licorice extract (Le) and . Le inhibited PEDV replication in a dose-dependent manner . By exploring the effect of Le on the life cycle of PEDV, we found that Le inhibited the attachment, internalization, and replication stages of the virus. , all five piglets in the PEDV-infected group died within 72 h. In comparison, the Le-treated group had a survival rate of 80 % at the same time, with significant relief of clinical symptoms, pathological damage, and viral loads in the jejunum and ileum. Our results suggested that Le can exert anti-PEDV effects and . Le is effective and inexpensive; therefore it has the potential to be developed as a new anti-PEDV drug.

Funding
This study was supported by the:
  • Key Research and Development Program Guidance Projects of Heilongjiang Province of China (Award GZ20220029)
    • Principle Award Recipient: DongboSun
  • Natural Science Foundation of Heilongjiang Province (Award LH2023C084)
    • Principle Award Recipient: XiaoxuXing
  • National Natural Science Foundation of China (Award U23A20236)
    • Principle Award Recipient: DongboSun
  • This is an open-access article distributed under the terms of the Creative Commons Attribution License.
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2024-03-12
2024-04-17
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