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ICTV Virus Taxonomy Profile: Filoviridae 2024
This article is part of the ICTV Virus Taxonomy Profiles collection.
Abstract
Filoviridae is a family of negative-sense RNA viruses with genomes of about 13.1–20.9 kb that infect fish, mammals and reptiles. The filovirid genome is a linear, non-segmented RNA with five canonical open reading frames (ORFs) that encode a nucleoprotein (NP), a polymerase cofactor (VP35), a glycoprotein (GP1,2), a transcriptional activator (VP30) and a large protein (L) containing an RNA-directed RNA polymerase (RdRP) domain. All filovirid genomes encode additional proteins that vary among genera. Several filovirids (e.g., Ebola virus, Marburg virus) are pathogenic for humans and highly virulent. This is a summary of the International Committee on Taxonomy of Viruses (ICTV) Report on the family Filoviridae, which is available at www.ictv.global/report/filoviridae.
- Received:
- Accepted:
- Published Online:
Keyword(s):
Ebola
,
filovirid
,
Filoviridae
,
filovirus
,
ICTV Report
,
Marburg virus
,
orthoebolavirus
,
orthomarburgvirus
and
taxonomy
Funding
-
U.S. Department of Homeland Security
(Award HSHQDC-15-C-00064)
- Principle Award Recipient: VictoriaWahl
-
Division of Intramural Research, National Institute of Allergy and Infectious Diseases
(Award HHSN272201800013C)
- Principle Award Recipient: H. KuhnJens
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