1887

Abstract

is a family of negative-sense RNA viruses with genomes of about 13.1–20.9 kb that infect fish, mammals and reptiles. The filovirid genome is a linear, non-segmented RNA with five canonical open reading frames (ORFs) that encode a nucleoprotein (NP), a polymerase cofactor (VP35), a glycoprotein (GP), a transcriptional activator (VP30) and a large protein (L) containing an RNA-directed RNA polymerase (RdRP) domain. All filovirid genomes encode additional proteins that vary among genera. Several filovirids (e.g., Ebola virus, Marburg virus) are pathogenic for humans and highly virulent. This is a summary of the International Committee on Taxonomy of Viruses (ICTV) Report on the family , which is available at www.ictv.global/report/filoviridae.

Funding
This study was supported by the:
  • U.S. Department of Homeland Security (Award HSHQDC-15-C-00064)
    • Principle Award Recipient: VictoriaWahl
  • Division of Intramural Research, National Institute of Allergy and Infectious Diseases (Award HHSN272201800013C)
    • Principle Award Recipient: H. KuhnJens
  • This is an open-access article distributed under the terms of the Creative Commons Attribution License.
Loading

Article metrics loading...

/content/journal/jgv/10.1099/jgv.0.001955
2024-02-02
2024-02-28
Loading full text...

Full text loading...

/deliver/fulltext/jgv/105/2/jgv001955.html?itemId=/content/journal/jgv/10.1099/jgv.0.001955&mimeType=html&fmt=ahah

References

  1. Kirchdoerfer RN, Wasserman H, Amarasinghe GK, Saphire EO. Filovirus structural biology: the molecules in the machine. Curr Top Microbiol Immunol 2017; 411:381–417 [View Article] [PubMed]
    [Google Scholar]
  2. Kuhn JH, Amarasinghe GK, Perry DL. Filoviridae. In Howley PM, Knipe DM, Whelan S. eds Fields Virology, 7th edn. Philadelphia, Pennsylvania, USA: Wolters Kluwer/Lippincott Williams & Wilkins; 2020 pp 449–503
    [Google Scholar]
  3. Pattnaik AK, Whitt MA. Filovirus transcription and replication. In Pattnaik AK, Whitt MA. eds Biology and Pathogenesis of Rhabdo- and Filoviruses Singapore: World Scientific Publishing; 2015 pp 515–555 [View Article]
    [Google Scholar]
  4. Yuan B, Peng Q, Cheng J, Wang M, Zhong J et al. Structure of the Ebola virus polymerase complex. Nature 2022; 610:394–401 [View Article] [PubMed]
    [Google Scholar]
  5. Wolf YI, Kazlauskas D, Iranzo J, Lucía-Sanz A, Kuhn JH et al. Origins and evolution of the global RNA virome. mBio 2018; 9:e02329–02318 [View Article] [PubMed]
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jgv/10.1099/jgv.0.001955
Loading
/content/journal/jgv/10.1099/jgv.0.001955
Loading

Data & Media loading...

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error