Bovine papular stomatitis virus as a vaccine vector for cattle

Gustavo Delhon; Sushil Khatiwada; David Doub; Seth Harris; Sabal Chaulagain; Mostafa El-Gaffary; Daniel L. Rock

doi:10.1099/jgv.0.001914

Volume 104, Issue 11

Short Communication

Open Access

Bovine papular stomatitis virus as a vaccine vector for cattle

Gustavo Delhon¹, Sushil Khatiwada^2,‡, David Doub², Seth Harris¹, Sabal Chaulagain^2,§, Mostafa El-Gaffary^2,# and Daniel L. Rock²
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Affiliations: ¹ School of Veterinary Medicine & Biomedical Sciences, University of Nebraska, Lincoln, Nebraska, USA ² Department of Pathobiology, College of Veterinary Medicine, University of Illinois, Urbana, Illinois, USA ^‡ Present address: Boehringer Ingelheim Animal Health, Ames, IA, USA ^§ Present address: Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA ^# Present address: Department of Veterinary Clinical Pathology, College of Veterinary Medicine, Cairo University, Giza, Egypt
*Correspondence: Gustavo Delhon, [email protected] *Correspondence: Daniel L. Rock, [email protected]
Published: 17 November 2023 https://doi.org/10.1099/jgv.0.001914

Abstract

Virus vectored vaccines are not available commercially for cattle even though compelling potential applications exist. Bovine papular stomatitis virus (BPSV), a highly prevalent parapoxvirus, causes self-limited oral lesions in cattle. Ability of virus to accommodate large amounts of foreign DNA, induce low level of antiviral immunity, and circulate and likely persist in cattle populations, make BPSV an attractive candidate viral vector. Here, recombinant BPSV were constructed expressing either Bovine herpesvirus 1 (BoHV-1) glycoprotein gD (BPSVgD), or gD and gB (BPSVgD/gB). Immunization of BPSV serologically-positive calves with BPSVgD or BPSVgD/gB induced BoHV-1 neutralization antibodies and provided protection for three of four animals following a high dose BoHV-1 challenge at day 70 pi. Results indicate BPSV suitability as a candidate virus vector for cattle vaccines.

Received: 31/07/2023
Accepted: 19/10/2023
Published Online: 17/11/2023

Keyword(s): bovine herpesvirus 1 , bovine papular stomatitis virus , challenge , immunization and virus vector

Funding

This study was supported by the:

National Institute of Food and Agriculture (Award 2019-67015-29966)
- Principle Award Recipient: DanielL. Rock

This is an open-access article distributed under the terms of the Creative Commons Attribution License. This article was made open access via a Publish and Read agreement between the Microbiology Society and the corresponding author’s institution.

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Bovine papular stomatitis virus as a vaccine vector for cattle

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Volume 104, Issue 11

Short Communication

Open Access

Bovine papular stomatitis virus as a vaccine vector for cattle

Abstract

Funding

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