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Volume 104, Issue 10

Desmoglein-2 and COVID-19 complications: insights into its role as a biomarker, pathogenesis and clinical implications Open Access

Abstract

Desmoglein-2 (DSG2) has emerged as a potential biomarker for coronavirus disease 2019 (COVID-19) complications, particularly cardiac and cardiovascular involvement. The expression of DSG2 in lung tissues has been detected at elevated levels, and circulating DSG2 levels correlate with COVID-19 severity. DSG2 may contribute to myocardial injury, cardiac dysfunction and vascular endothelial dysfunction in COVID-19. Monitoring DSG2 levels could aid in risk stratification, early detection and prognostication of COVID-19 complications. However, further research is required to validate DSG2 as a biomarker. Such research will aim to elucidate its precise role in pathogenesis, establishing standardized assays for its measurement and possibly identifying therapeutic targets.

  • Received:
  • Accepted:
  • Published Online:
Keyword(s): autoantibodies , autoimmunity , biomarker , COVID-19 , desmoglein-2 and SARS-CoV-2
© 2023 The Authors
  • This is an open-access article distributed under the terms of the Creative Commons Attribution License. This article was made open access via a Publish and Read agreement between the Microbiology Society and the corresponding author’s institution.
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2023-10-10
2024-04-27
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Desmoglein-2 and COVID-19 complications: insights into its role as a biomarker, pathogenesis and clinical implications
J. Gen. Virol. 104, 001902 (2023); https://doi.org/10.1099/jgv.0.001902
/content/journal/jgv/10.1099/jgv.0.001902
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