1887

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Volume 103, Issue 11

Complete genome and pathogenesis of a novel recombinant Senecavirus A isolate in P.R. China No Access

Abstract

Senecavirus A (SVA), formerly called Seneca Valley virus (SVV) was first isolated from the USA in 2002. This study isolated an SVA strain from a pig herd in Shandong Province, PR China and designated it SVA-CH-SDGT-2017. The full-length genome, excluding the poly(A) tails of the SVA isolates, was 7280 nucleotides long, with the genomic organization resembling and sharing high nucleotide identities of 90.7–96.9 % with other previously reported SVA isolates. To investigate the pathogenicity of the SVA isolates, experimental infections of pigs were performed. The SVA strains successfully infected the pigs, as evidenced by the presence of virus shedding and robust serum neutralizing antibody responses. In addition, the contact-exposed experiment showed that the virus shedding of the contact-exposed pigs was approximately a 100-fold reduced compared to that of the inoculated group, indicating that the virus is capable of transmission to pigs. Our findings provide useful data for studying the pathogenesis and transmission of SVA in pigs.

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Keyword(s): full-length genome , pathogenesis , pigs , Senecavirus A and transmission
© 2022 The Authors
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/content/journal/jgv/10.1099/jgv.0.001788
2022-11-23
2024-04-29
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Complete genome and pathogenesis of a novel recombinant Senecavirus A isolate in P.R. China
J. Gen. Virol. 103, 001788 (2022); https://doi.org/10.1099/jgv.0.001788
/content/journal/jgv/10.1099/jgv.0.001788
/content/journal/jgv/10.1099/jgv.0.001788
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