Viruses in the family are found in a wide variety of vertebrate hosts. Enveloped virions are 80–100 nm in diameter with an inner core containing the viral genome and replicative enzymes. Core morphology is often characteristic for viruses within the same genus. Replication involves reverse transcription and integration into host cell DNA, resulting in a provirus. Integration into germline cells can result in a heritable provirus known as an endogenous retrovirus. This is a summary of the International Committee on Taxonomy of Viruses (ICTV) Report on the family , which is available at ictv.global/report/retroviridae.

Keyword(s): AIDS , HIV , ICTV Report , Retroviridae and taxonomy
This study was supported by the:
  • Wellcome Trust (Award WT108418AIA)
    • Principle Award Recipient: ICTVConsortium
  • This is an open-access article distributed under the terms of the Creative Commons Attribution License.

Article metrics loading...

Loading full text...

Full text loading...



  1. Goff SP. Retroviridae . In Knipe DM, Howley PM. eds Fields Virology: Lippincott, Williams & Wilkins; 2013 pp 1424–1473
    [Google Scholar]
  2. Lindemann D, Steffen I, Pöhlmann S. Cellular entry of retroviruses. Adv Exp Med Biol 2013; 790:128–149 [View Article] [PubMed]
    [Google Scholar]
  3. Overbaugh J, Miller AD, Eiden MV. Receptors and entry cofactors for retroviruses include single and multiple transmembrane-spanning proteins as well as newly described glycophosphatidylinositol-anchored and secreted proteins. Microbiol Mol Biol Rev 2001; 65:371–389 [View Article] [PubMed]
    [Google Scholar]
  4. Coffin JM, Hughes SH, Varmus HE. Retroviruses Cold Spring Harbor (NY: Cold Spring Harbor Laboratory Press; 1997
    [Google Scholar]
  5. Lesbats P, Engelman AN, Cherepanov P. Retroviral DNA Integration. Chem Rev 2016; 116:12730–12757 [View Article] [PubMed]
    [Google Scholar]
  6. Pornillos O, Ganser-Pornillos BK. Maturation of retroviruses. Curr Opin Virol 2019; 36:47–55 [View Article] [PubMed]
    [Google Scholar]
  7. Maeda N, Fan H, Yoshikai Y. Oncogenesis by retroviruses: old and new paradigms. Rev Med Virol 2008; 18:387–405 [View Article] [PubMed]
    [Google Scholar]
  8. Krupovic M, Blomberg J, Coffin JM, Dasgupta I, Fan H et al. Ortervirales: new virus order unifying five families of reverse-transcribing viruses. J Virol 2018; 92:e00515-18 [View Article] [PubMed]
    [Google Scholar]

Data & Media loading...

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error