1887

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Volume 102, Issue 5

Neutralizing Ljungan virus antibodies in children with newly diagnosed type 1 diabetes No Access

Abstract

(LV), a of the family, first isolated from a bank vole at the Ljungan river in Sweden, has been implicated in the risk for autoimmune type 1 diabetes. An assay for neutralizing Ljungan virus antibodies (NLVA) was developed using the original 87–012 LV isolate. The goal was to determine NLVA titres in incident 0–18 years old newly diagnosed type 1 diabetes patients (=67) and school children controls (=292) from Jämtland county in Sweden. NLVA were found in 41 of 67 (61 %) patients compared to 127 of 292 (44 %) controls (=0.009). In the type 1 diabetes patients, NLVA titres were associated with autoantibodies to glutamic acid decarboxylase (GADA) (=0.023), but not to autoantibodies against insulin (IAA) or islet antigen-2 (IA-2A). The NLVA assay should prove useful for further investigations to determine levels of LV antibodies in patients and future studies to determine a possible role of LV in autoimmune type 1 diabetes.

  • Received:
  • Accepted:
  • Published Online:
Keyword(s): beta cell autoimmunity , glutamic acid decarboxylase autoantibodies , human pathogen , Ljungan Virus , neutralization assay and Type 1 diabetes
Funding
This study was supported by the:
  • Stiftelsen Axel Tielmans Minnesfond
    • Principle Award Recipient: AnnikaLundstig
  • H.K.H. Kronprinsessan Lovisas Förening för Barnasjukvård (SE)
    • Principle Award Recipient: AnnikaLundstig
  • Stiftelsen Familjen Ernfors Fond
    • Principle Award Recipient: AnnikaLundstig
  • Sven Mattssons Stiftelse
    • Principle Award Recipient: AnnikaLundstig
  • Lunds Revisorer
    • Principle Award Recipient: AnnikaLundstig
  • Lisa och Johan Grönbergs Stiftelse
    • Principle Award Recipient: AnnikaLundstig
  • Sydvästra Skånes Diabetesförening
    • Principle Award Recipient: AnnikaLundstig
  • Stiftelsen Olle Engkvist Byggmästare
    • Principle Award Recipient: AnnikaLundstig
  • The Swedish Child Diabetes Foundation
    • Principle Award Recipient: AnnikaLundstig
© 2021 The Authors

Erratum

An erratum has been published for this content:
Erratum: Neutralizing Ljungan virus antibodies in children with newly diagnosed type 1 diabetes
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/content/journal/jgv/10.1099/jgv.0.001602
2021-05-21
2024-05-08
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Neutralizing Ljungan virus antibodies in children with newly diagnosed type 1 diabetes
J. Gen. Virol. 102, 001602 (2021); https://doi.org/10.1099/jgv.0.001602
/content/journal/jgv/10.1099/jgv.0.001602
/content/journal/jgv/10.1099/jgv.0.001602
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