1887

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Volume 102, Issue 4

Effective inactivation of SARS-CoV-2 by commercially available mouthwashes Open Access

Abstract

Infectious SARS-CoV-2 can be recovered from the oral cavities and saliva of COVID-19 patients with potential implications for disease transmission. Reducing viral load in patient saliva using antiviral mouthwashes may therefore have a role as a control measure in limiting virus spread, particularly in dental settings. Here, the efficacy of SARS-CoV-2 inactivation by seven commercially available mouthwashes with a range of active ingredients were evaluated . We demonstrate ≥4.1 to ≥5.5 log reduction in SARS-CoV-2 titre following a 1 min treatment with commercially available mouthwashes containing 0.01–0.02 % stabilised hypochlorous acid or 0.58 % povidone iodine, and non-specialist mouthwashes with both alcohol-based and alcohol-free formulations designed for home use. In contrast, products containing 1.5 % hydrogen peroxide or 0.2 % chlorhexidine gluconate were ineffective against SARS-CoV-2 in these tests. This study contributes to the growing body of evidence surrounding virucidal efficacy of mouthwashes/oral rinses against SARS-CoV-2, and has important applications in reducing risk associated with aerosol generating procedures in dentistry and potentially for infection control more widely.

  • Received:
  • Accepted:
  • Published Online:
Keyword(s): coronavirus , COVID-19 , inactivation , mouthwash , oral rinse and SARS-CoV-2
Funding
This study was supported by the:
  • Public Health England
    • Principle Award Recipient: NotApplicable
© 2021 Crown Copyright
  • This is an open-access article distributed under the terms of the Creative Commons Attribution License. This article was made open access via a Publish and Read agreement between the Microbiology Society and the corresponding author’s institution.
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2021-04-29
2024-05-04
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Effective in vitro inactivation of SARS-CoV-2 by commercially available mouthwashes
J. Gen. Virol. 102, 001578 (2021); https://doi.org/10.1099/jgv.0.001578
/content/journal/jgv/10.1099/jgv.0.001578
/content/journal/jgv/10.1099/jgv.0.001578
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