is a family of icosahedral, internal membrane-containing bacterial viruses with circular, single-stranded DNA genomes. The family includes the genus, , with the species, . Flavobacterium phage FLiP was isolated with its Gram-negative host bacterium from a boreal freshwater habitat in Central Finland in 2010. It is the first described single-stranded DNA virus with an internal membrane and shares minimal sequence similarity with other known viruses. The virion organization (pseudo =21 ) and major capsid protein fold (double-β-barrel) resemble those of Pseudoalteromonas phage PM2 (family ), which has a double-stranded DNA genome. A similar major capsid protein fold is also found in other double-stranded DNA viruses in the kingdom . This is a summary of the International Committee on Taxonomy of Viruses (ICTV) report on the family , which is available at ictv.global/report/finnlakeviridae.

This study was supported by the:
  • ICTV Consortium , Wellcome Trust , (Award WT108418AIA)
  • Hanna M. Oksanen , Academy of Finland
  • Minna M. Poranen , Sigrid Juséliuksen Säätiö
  • Minna M. Poranen , Jane ja Aatos Erkon Säätiö
  • Lotta-Riina Sundberg , Jane ja Aatos Erkon Säätiö
  • Lotta-Riina Sundberg , Academy of Finland , (Award 314939)
  • Elina Laanto , Academy of Finland , (Award 321985)
  • Sari Mäntynen , Academy of Finland , (Award 323426)

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  1. Laanto E, Mäntynen S, De Colibus L, Marjakangas J, Gillum A et al. Virus found in a boreal lake links ssDNA and dsDNA viruses. Proc Natl Acad Sci USA 2017; 114:8378–8383 [CrossRef][PubMed]
    [Google Scholar]
  2. Huiskonen JT, Kivelä HM, Bamford DH, Butcher SJ. The PM2 virion has a novel organization with an internal membrane and pentameric receptor binding spikes. Nat Struct Mol Biol 2004; 11:850–856 [CrossRef][PubMed]
    [Google Scholar]
  3. Koonin EV, Dolja VV, Krupovic M, Varsani A, Wolf YI et al. Global organization and proposed megataxonomy of the virus world. Microbiol Mol Biol Rev 2020; 84: [CrossRef][PubMed]
    [Google Scholar]
  4. Benson SD, Bamford JK, Bamford DH, Burnett RM. Viral evolution revealed by bacteriophage PRD1 and human adenovirus coat protein structures. Cell 1999; 98:825–833 [CrossRef][PubMed]
    [Google Scholar]
  5. Yutin N, Bäckström D, Ettema TJG, Krupovic M, Koonin EV. Vast diversity of prokaryotic virus genomes encoding double jelly-roll major capsid proteins uncovered by genomic and metagenomic sequence analysis. Virol J 2018; 15:67 [CrossRef][PubMed]
    [Google Scholar]

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