1887

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Volume 100, Issue 11

-mediated antiviral protection is cell-autonomous Free

Abstract

Vector-borne viral diseases pose significant risks to human health. To control the transmission of these viruses, a number of approaches are required. The ability of the intracellular bacteria to limit viral accumulation and transmission in some arthropod hosts, highlights its potential as a biocontrol agent. Whilst can reduce the transmission of several epidemiologically important viruses, protection is not consistent amongst all insects, viruses and strains of , which confounds elucidation of the mechanisms that underly this protection. Evidence of different mechanisms has emerged, but is not always consistent, suggesting the tripartite interaction may be complex. Here we provide evidence that -mediated antiviral protection is dependent on the presence of in individual cells, and cannot be conferred to surrounding cells. Our results suggest that protection is cell-autonomous, and this has several mechanistic implications, which can direct future research.

  • Received:
  • Accepted:
  • Published Online:
Keyword(s): antiviral protection , arbovirus , Drosophila C virus , insect virus and Wolbachia
© 2019 The Authors
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2019-11-01
2024-04-26
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Wolbachia-mediated antiviral protection is cell-autonomous
J. Gen. Virol. 100, 1587 (2019); https://doi.org/10.1099/jgv.0.001342
/content/journal/jgv/10.1099/jgv.0.001342
/content/journal/jgv/10.1099/jgv.0.001342
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