1887

Journal of General Virology header logo

Volume 83, Issue 10

Evidence of recombination in the capsid-coding region of type A foot-and-mouth disease virus Free

Abstract

Recombination is one of the factors that contribute to genetic diversity in foot-and-mouth disease virus (FMDV). Similarity and bootscan analyses have provided evidence of recombination in the capsid-coding (P1) region of the virus. In the present study, of the 14 subtype A22 field isolates that were distributed in three previously described genotypes (IV, VI and VII) based on the 1D (VP1-encoding) gene sequence (Tosh ., 2002), one isolate (IND 170/88) was found to be a hybrid of genotypes VI and VII in the P1 region. VP1, VP4, the 5′ region of VP2 and the 3′ region of VP3 of this virus were characteristic of genotype VI, whereas the remaining 3′ region of VP2 and the 5′ region of VP3 were characteristic of genotype VII. No insertion or deletion was observed in the recombinant virus. Recombination in the P1 region may provide an escape mechanism for the virus.

  • Received:
  • Accepted:
  • Published Online:
© Microbiology Society
Loading

Article metrics loading...

/content/journal/jgv/10.1099/0022-1317-83-10-2455
2002-10-01
2024-04-26
Loading full text...

Full text loading...

/deliver/fulltext/jgv/83/10/0832455a.html?itemId=/content/journal/jgv/10.1099/0022-1317-83-10-2455&mimeType=html&fmt=ahah

References

  1. Acharya R., Fry E., Stuart D., Fox G., Rowlands D., Brown F. 1989; The three-dimensional structure of foot-and-mouth disease virus at 2·9 Å resolution. Nature 337:709–716
     [Google Scholar]
  2. Anon. 1998–2001 Annual report: All India Coordinated Research Project for Epidemiological Studies on Foot-and-Mouth Disease New Delhi: Indian Council of Agricultural Research;
     [Google Scholar]
  3. Baxt B., Vakharia V., Moore D. M., Franke A. J., Morgan D. O. 1989; Analysis of neutralizing antigenic sites on the surface of type A12 foot-and-mouth disease virus. Journal of Virology 63:2143–2151
     [Google Scholar]
  4. Bolwell C., Brown A. L., Barnett P. V., Campbell R. O., Clarke B. E., Parry N. R., Ouldridge E. J., Brown F., Rowlands D. J. 1989a; Host cell selection of antigenic variants of foot-and-mouth disease virus. Journal of General Virology 70:45–57
     [Google Scholar]
  5. Bolwell C., Clarke B. E., Parry N. R., Ouldridge E. J., Brown F., Rowlands D. J. 1989b; Epitope mapping of foot-and-mouth disease virus with neutralizing monoclonal antibodies. Journal of General Virology 70:59–68
     [Google Scholar]
  6. Borrego B., Novella I. S., Giralt E., Andreu D., Domingo E. 1993; Distinct repertoire of antigenic variants of foot-and-mouth disease virus in the presence or absence of immune selection. Journal of Virology 67:6071–6079
     [Google Scholar]
  7. Cammack N., Phillips A., Dunn G., Patel V., Minor P. D. 1988; Intertypic genomic rearrangements of poliovirus strains in vaccines. Virology 167:507–514
     [Google Scholar]
  8. Domingo E., Davila M., Ortin J. 1980; Nucleotide sequence heterogeneity of the RNA from a natural population of foot-and-mouth disease virus. Gene 11:333–346
     [Google Scholar]
  9. Domingo E., Martinez-Salas E., Sobrino F., de la Torre J. C., Portela A., Ortin J., Lopez-Galindez C., Perez-Brena P., Villanueva N., Najera R., VandePol S., Steinhauer D., De Polo N., Holland J. J. 1985; The quasispecies (extremely heterogeneous) nature of viral RNA genome populations: biological relevance – a review. Gene 40:1–8
     [Google Scholar]
  10. Domingo E., Mateu M. G., Martinez M. A., Dopazo J., Moya A., Sobrino F. 1990; Genetic variability and antigenic diversity of foot-and-mouth disease virus. In Applied Virology Research , vol. 2, Virus Variation and Epidemiology pp 233–266 Edited by Kurstak E., Marusyk R. G., Murphy S. A., Van Regenmortel M. H. V. New York: Plenum;
     [Google Scholar]
  11. Domingo E., Escarmis C., Martinez M. A., Martinez-Salas E., Mateu M. G. 1992; Foot-and-mouth disease virus populations are quasispecies. Current Topics in Microbiology and Immunology 176:33–47
     [Google Scholar]
  12. Domingo E., Diez J., Martinez M. A., Hernandez J. H., Holguin A., Borrego B., Mateu M. G. 1993; New observations on antigenic diversification of RNA viruses. Antigenic variation is not dependent on immune selection. Journal of General Virology 74:2039–2045
     [Google Scholar]
  13. Felsenstein J. 1993 phylip (Phylogeny Inference Package), version 3.5c University of Washington; Seattle, WA, USA:
     [Google Scholar]
  14. Furione M., Guillot S., Otelea D., Balanant J., Candrea A., Crainic R. 1993; Polioviruses with natural recombinant genomes isolated from vaccine-associated paralytic poliomyelytis. Virology 196:199–208
     [Google Scholar]
  15. Gebauer F., de la Torrre J. C., Gomes I., Mateu M. G., Barahona H., Tiraboschi B., Bergmann I., Auge de Mello P., Domingo E. 1988; Rapid selection of genetic and antigenic variants of foot-and-mouth disease virus during persistence in cattle. Journal of Virology 62:2041–2049
     [Google Scholar]
  16. Giraudo A. T., Sagedahl A., Bergmann I. E., La Torre J. L., Scodeller E. A. 1987; Isolation and characterization of recombinants between attenuated and virulent aphthovirus strains. Journal of Virology 61:419–425
     [Google Scholar]
  17. Gurumurthy C. B., Sanyal A., Venkataramanan R., Tosh C., George M., Hemadri D. 2002; Genetic diversity in the VP1 gene of foot-and-mouth disease virus serotype Asia 1. Archives of Virology 147:85–102
     [Google Scholar]
  18. Holguin A., Hernandez J., Martinez M. A., Mateu M. G., Domingo E. 1997; Differential restrictions on antigenic variation among antigenic sites of foot-and-mouth disease virus in the absence of antibody selection. Journal of General Virology 78:601–609
     [Google Scholar]
  19. King A. M. Q. 1988; Recombination in positive strand RNA viruses. In RNA Genetics pp 149–165 Edited by Domingo E., Holland J. J., Ahlquist P. Boca Raton, FL: CRC Press;
     [Google Scholar]
  20. King A. M. Q., McCahon D., Slade W. R., Newman J. W. I. 1982a; Biochemical evidence of recombination within the unsegmented RNA genome of aphthovirus. Journal of Virology 41:66–77
     [Google Scholar]
  21. King A. M. Q., McCahon D., Slade W. R., Newman J. W. I. 1982b; Recombination in RNA. Cell 29:921–928
     [Google Scholar]
  22. King A. M. Q., McCahon D., Saunders K., Newman J. W. I., Slade W. R. 1985; Multiple sites of recombination within the RNA genome of foot-and-mouth disease virus. Virus Research 3:373–384
     [Google Scholar]
  23. Kirkegaard K., Baltimore D. 1986; The mechanism of RNA recombination in poliovirus. Cell 47:433–443
     [Google Scholar]
  24. Knowles N. J., Samuel A. R. 1995; Polymerase chain reaction amplification and cycle sequencing of the 1D (VP1) gene of foot-and-mouth disease viruses. In Report of the Session of the Research Group of the Standing Technical Committee of the European Commission for the Control of Foot-and-Mouth Disease. Vienna, Austria. September 1994 pp 45–53 Rome: FAO;
     [Google Scholar]
  25. Krebs O., Marquardt O. 1993; Identification and characterization of foot-and-mouth disease virus O1 Burgwedel/1987 as an intertypic recombinant. Journal of General Virology 73:613–619
     [Google Scholar]
  26. Lai M. M. C. 1992; Genetic recombination in RNA viruses. Current Topics in Microbiology and Immunology 176:21–32
     [Google Scholar]
  27. McCahon D., Slade W. R. 1981; A sensitive method for the detection and isolation of recombinants of foot-and-mouth disease virus. Journal of General Virology 53:333–342
     [Google Scholar]
  28. McCahon D., King A. M. Q., Roe D. S., Slade W. R., Newman J. W. I., Cleary A. M. 1985; Isolation and biochemical characterization of intertypic recombinants of foot-and-mouth disease virus. Virus Research 3:87–100
     [Google Scholar]
  29. Malirat V., Auge de Mello P., Tiraboschi B., Beck E., Gomes I., Bergmann I. E. 1994; Genetic variation of foot-and-mouth disease virus during persistent infection in cattle. Virus Research 34:31–48
     [Google Scholar]
  30. Nayak B., Pattnaik B., Tosh C., Sanyal A., Hemadri D., Patil S. S., Venkataramanan R. 2001; Genetic and antigenic analysis of type A foot-and-mouth disease viruses isolated in India during 1987–1996. Acta Virologica 45:13–21
     [Google Scholar]
  31. Ouldridge E. J., Barnett P. V., Hingley P. J., Head M., Rweyemamu M. M. 1984; The differentiation of foot-and-mouth disease virus strains using an indirect sandwich enzyme-linked immunosorbent assay saturation model. Journal of Biological Standardization 12:367–377
     [Google Scholar]
  32. Page R. D. M. 1996; treeview: an application to display phylogenetic trees on personal computers. Computer Applications in the Biosciences 12:357–358
     [Google Scholar]
  33. Pereira H. G. 1977; Subtyping of foot-and-mouth disease virus. Developments in Biological Standardization 35:167–174
     [Google Scholar]
  34. Pringle C. R. 1965; Evidence of genetic recombination in foot-and-mouth disease virus. Virology 25:48–54
     [Google Scholar]
  35. Ray S. C. 1999; SimPlot for Windows 95, version 2.5. Distributed by the author (www.med.jhu.edu/deptmed/sray/download
  36. Reuckert R. R. 1996; Picornaviridae : the viruses and their replication. In Fields Virology pp 609–654 Edited by Fields B. N., Knipe D. M., Howley P. M. Philadelphia: Lippincott–Raven;
     [Google Scholar]
  37. Roberts P. J., Belsham G. J. 1995; Identification of critical amino acids within the foot-and-mouth disease virus leader protein, a cysteine protease. Virology 213:140–146
     [Google Scholar]
  38. Robertson D. L., Sharp P. M., McCutchan F. E., Hahn B. H. 1995; Recombination in HIV-1. Nature 374:124–126
     [Google Scholar]
  39. Sabarinath G. P. 2001; Comparison of nucleotide sequence of structural protein encoding (P1) region of foot-and-mouth disease virus serotype O isolates. MVSc thesis (submitted to the Deemed University, Indian Veterinary Research Institute, Izatnagar, Uttar Pradesh, India
  40. Salminen M. O., Carr J. K., Burke D. S., McCutchan F. E. 1995; Identification of breakpoints in intergenotypic recombinants of HIV type 1 by bootscanning. AIDS Research and Human Retroviruses 11:1423–1425
     [Google Scholar]
  41. Salt J. S. 1993; The carrier state in foot-and-mouth disease – an immunological review. British Veterinary Journal 149:207–223
     [Google Scholar]
  42. Samuel A. R., Knowles N. J. 2001; Foot-and-mouth disease type O viruses exhibit genetically and geographically distinct evolutionary lineages (topotypes). Journal of General Virology 82:609–621
     [Google Scholar]
  43. Santti J., Hyypia T., Kinnunen L., Salminen M. 1999; Evidence of recombination among enteroviruses. Journal of Virology 73:8741–8749
     [Google Scholar]
  44. Sobrino F., Davila M., Ortin J., Domingo E. 1983; Multiple genetic variants arise in the course of replication of foot-and-mouth disease virus in cell culture. Virology 128:310–318
     [Google Scholar]
  45. Thomas A. A. M., Woortmeijer R. J., Puijk W., Barteling S. J. 1988; Antigenic sites on foot-and-mouth disease virus type A10. Journal of Virology 62:2782–2789
     [Google Scholar]
  46. Thompson J. D., Higgins D. G., Gibson T. J. 1994; clustal w: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, positions-specific gap penalties and weight matrix choice. Nucleic Acids Research 22:4673–4680
     [Google Scholar]
  47. Tosh C., Venkataramanan R., Hemadri D., Sanyal A., Samuel A. R., Knowles N. J., Kitching R. P. 2000; Nucleotide sequence of the structural protein-encoding region of foot-and-mouth disease virus A22-India. Virus Genes 20269–276
     [Google Scholar]
  48. Tosh C., Sanyal A., Hemadri D., Venkataramanan R. 2002; Phylogenetic analysis of serotype A foot-and-mouth disease virus isolated in India between 1977 and 2000. Archives of Virology 147:493–513
     [Google Scholar]
  49. Wilson V., Taylor P., Desselberger U. 1988; Crossover regions in foot-and-mouth disease virus (FMDV) recombinants correspond to regions of high local secondary structure. Archives of Virology 102:131–139
     [Google Scholar]
  50. Woodbury E. L. 1995; A review of the possible mechanisms for the persistence of foot-and-mouth disease virus. Epidemiology and Infection 114:1–13
     [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jgv/10.1099/0022-1317-83-10-2455
Loading
Evidence of recombination in the capsid-coding region of type A foot-and-mouth disease virus
J. Gen. Virol. 83, 2455 (2002); https://doi.org/10.1099/0022-1317-83-10-2455
/content/journal/jgv/10.1099/0022-1317-83-10-2455
/content/journal/jgv/10.1099/0022-1317-83-10-2455
Loading

Data & Media loading...

Most cited Most Cited RSS feed

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error