1887

Abstract

The establishment of persistent infections with non-cytopathic bovine virus diarrhoea virus (ncpBVDV) is crucial for the maintenance of BVDV in cattle populations. Also, super-infection of persistently infected individuals with antigenically homologous cytopathic BVDV (cpBVDV) results in fatal mucosal disease. Persistent infection with ncpBVDV is established by infection of the foetus during the first trimester of pregnancy. It has been shown previously that foetal infection with cpBVDV does not result in persistent infection. Infection of cells has demonstrated that cpBVDV induces type I interferon (IFN), whereas ncpBVDV fails to induce IFN. In this study we demonstrate that foetal challenge with cpBVDV results in IFN production, whereas ncpBVDV does not. These findings strongly suggest that the ability of ncpBVDV to inhibit the induction of type I IFN has evolved to enable the virus to establish persistent infection in the early foetus.

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2001-08-01
2019-08-22
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References

  1. Adler, B., Adler, H., Pfister, H., Jungi, T. W. & Peterhans, E. ( 1997; ). Macrophages infected with cytopathic bovine viral diarrhoea virus release a factor(s) capable of priming uninfected macrophages for activation-induced apoptosis. Journal of Virology 71, 3255-3258.
    [Google Scholar]
  2. Bielefeldt-Ohmann, H. & Babuik, L. A. ( 1988; ). Influence of interferons alpha II and gamma and tumour necrosis factor on persistent infection with bovine viral diarrhoea virus in vitro. Journal of General Virology 69, 1399-1403.[CrossRef]
    [Google Scholar]
  3. Brownlie, J., Clarke, M. C. & Howard, C. J. ( 1984; ). Experimental production of fatal mucosal disease in cattle. Veterinary Record 114, 535-536.[CrossRef]
    [Google Scholar]
  4. Brownlie, J., Clarke, M. C. & Howard, C. J. ( 1989; ). Experimental infection of cattle in early pregnancy with a cytopathic strain of bovine virus diarrhoea virus. Research in Veterinary Science 46, 307-311.
    [Google Scholar]
  5. Collen, T., Douglas, A. J., Paton, D. J., Zhang, G. & Morrison, W. I. ( 2000; ). Single amino acid differences are sufficient for CD4+ T-cell recognition of a heterologous virus by cattle persistently infected with bovine viral diarrhea virus. Virology 276, 70-82.[CrossRef]
    [Google Scholar]
  6. Cella, M., Salio, M., Sakakibara, Y., Langen, H., Julkunen, I. & Lanzavecchia, A. ( 1999; ). Maturation, activation, and protection of dendritic cells induced by double-stranded RNA. Journal of Experimental Medicine 189, 821-829.[CrossRef]
    [Google Scholar]
  7. Diderholm, H. & Dinter, Z. ( 1966; ). Interference between strains of bovine virus diarrhea virus and their capacity to suppress interferon of a heterologous virus. Proceedings of the Society for Experimental Biology and Medicine 121, 976-980.[CrossRef]
    [Google Scholar]
  8. Fray, M. D., Supple, E. A., Morrison, W. I. & Charleston, B. ( 2000; ). Germinal centre localization of bovine viral diarrhoea virus in persistently infected animals. Journal of General Virology 81, 1669-1673.
    [Google Scholar]
  9. Fray, M. D., Mann, G. E. & Charleston, B. ( 2001; ). Validation of a Mx/CAT reporter gene assay for the quantification of bovine type-I interferon. Journal of Immunological Methods 249, 235-244.[CrossRef]
    [Google Scholar]
  10. Kim, C. H., Johnson, M. C., Drennan, J. D., Simon, B. E., Thomann, E. & Leong, J. A. ( 2000; ). DNA vaccines encoding viral glycoproteins induce nonspecific immunity and Mx protein synthesis in fish. Journal of Virology 74, 7048-7054.[CrossRef]
    [Google Scholar]
  11. Kracke, A., von Wussow, P., Al-Masri, A. N., Dalley, G., Windhagen, A. & Heidenreich, F. ( 2000; ). Mx proteins in blood leukocytes for monitoring interferon beta-1b therapy in patients with MS. Neurology 54, 193-199.[CrossRef]
    [Google Scholar]
  12. Nakamura, S., Shimazaki, T., Sakamoto, K., Fukusho, A., Inoue, Y. & Ogawa, N. ( 1995; ). Enhanced replication of orbiviruses in bovine testicle cells infected with bovine viral diarrhoea virus. Journal of Veterinary Medical Science 57, 677-681.[CrossRef]
    [Google Scholar]
  13. Paton, D. J., Christiansen, K. H., Alenius, S., Cranwell, M. P., Pritchard, G. C. & Drew, T. W. ( 1998; ). Prevalence of antibodies to bovine virus diarrhoea virus and other viruses in bulk tank milk in England and Wales. Veterinary Record 142, 385-391.[CrossRef]
    [Google Scholar]
  14. Rinaldo, C. R., Isackson, D. W., Overall, J. C., Glasgow, L. A., Brown, T. T., Bistner, S. I., Gillespie, J. H. & Scott, F. W. ( 1976; ). Fetal and adult bovine interferon production during bovine viral diarrhea virus infection. Infection and Immunity 14, 1189-1194.
    [Google Scholar]
  15. Ronni, T., Sareneva, T., Pirhonen, J. & Julkunen, I. ( 1995; ). Activation of IFN-alpha, IFN-gamma, MxA, and IFN regulatory factor 1 genes in influenza A virus-infected human peripheral blood mononuclear cells. Journal of Immunology 154, 2764-2774.
    [Google Scholar]
  16. Rossi, C. R. & Kiesel, G. K. ( 1980; ). Factors affecting the production of bovine type 1 interferon on bovine embryonic lung cells by polyriboinosinic-polyribocytidylic acid. American Journal of Veterinary Research 41, 557-560.
    [Google Scholar]
  17. Zhang, G., Aldridge, S., Clarke, M. C. & McCauley, J. W. ( 1996; ). Cell death induced by cytopathic bovine viral diarrhoea virus is mediated by apoptosis. Journal of General Virology 77, 1677-1681.[CrossRef]
    [Google Scholar]
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