1887

Abstract

Herpes simplex virus type 1 (HSV-1) glycoproteins gB, gD and gHL are capable of inducing cell fusion when expressed from plasmid vectors in the absence of any other virus components. Fusion requires the expression of all four glycoproteins on the same membrane, since they are unable to cooperate to induce syncytium formation. In addition, the fusion event is dependent on the expression of a gD receptor on target cell membranes and does not require the presence of cell-surface glycosaminoglycans.

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2001-06-01
2019-10-23
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References

  1. Cai, W. H., Gu, B. & Person, S. ( 1988; ). Role of glycoprotein B of herpes simplex virus type 1 in viral entry and cell fusion. Journal of Virology 62, 2596-2604.
    [Google Scholar]
  2. Cocchi, F., Menotti, L., Dubreuil, P., Lopez, M. & Campadelli-Fiume, G. ( 2000; ). Cell-to-cell spread of wild-type herpes simplex virus type 1, but not of syncytial strains, is mediated by the immunoglobulin-like receptors that mediate virion entry, nectin1 (PRR1/HveC/HIgR) and nectin2 (PRR2/HveB). Journal of Virology 74, 3909-3917.[CrossRef]
    [Google Scholar]
  3. Davis-Poynter, N., Bell, S., Minson, T. & Browne, H. ( 1994; ). Analysis of the contributions of herpes simplex virus type 1 membrane proteins to the induction of cell–cell fusion. Journal of Virology 68, 7586-7590.
    [Google Scholar]
  4. Forrester, A., Farrell, H., Wilkinson, G., Kaye, J., Davis-Poynter, N. & Minson, T. ( 1992; ). Construction and properties of a mutant of herpes simplex virus type 1 with glycoprotein H coding sequences deleted. Journal of Virology 66, 341-348.
    [Google Scholar]
  5. Handler, C. G., Eisenberg, R. J. & Cohen, G. H. ( 1996a; ). Oligomeric structure of glycoproteins in herpes simplex virus type 1. Journal of Virology 70, 6067-6075.
    [Google Scholar]
  6. Handler, C. G., Cohen, G. H. & Eisenberg, R. J. ( 1996b; ). Cross-linking of glycoprotein oligomers during herpes simplex virus type 1 entry. Journal of Virology 70, 6076-6082.
    [Google Scholar]
  7. Keller, K. M., Brauer, P. R. & Keller, J. M. ( 1989; ). Modulation of cell surface heparan sulfate structure by growth of cells in the presence of chlorate. Biochemistry 28, 8100-8107.[CrossRef]
    [Google Scholar]
  8. Krummenacher, C., Nicola, A. V., Whitbeck, J. C., Lou, H., Hou, W., Lambris, J. D., Geraghty, R. J., Spear, P. G., Cohen, G. H. & Eisenberg, R. J. ( 1998; ). Herpes simplex virus glycoprotein D can bind to poliovirus receptor-related protein 1 or herpesvirus entry mediator, two structurally unrelated mediators of virus entry. Journal of Virology 72, 7064-7074.
    [Google Scholar]
  9. Laquerre, S., Argnani, R., Anderson, D. B., Zucchini, S., Manservigi, R. & Glorioso, J. C. ( 1998; ). Heparan sulfate proteoglycan binding by herpes simplex virus type 1 glycoproteins B and C, which differ in their contributions to virus attachment, penetration, and cell-to-cell spread. Journal of Virology 72, 6119-6130.
    [Google Scholar]
  10. Ligas, M. W. & Johnson, D. C. ( 1988; ). A herpes simplex virus mutant in which glycoprotein D sequences are replaced by β-galactosidase sequences binds to but is unable to penetrate into cells. Journal of Virology 62, 1486-1494.
    [Google Scholar]
  11. Muggeridge, M. I. ( 2000; ). Characterization of cell–cell fusion mediated by herpes simplex virus 2 glycoproteins gB, gD, gH and gL in transfected cells. Journal of General Virology 81, 2017-2027.
    [Google Scholar]
  12. Nicola, A. V., Ponce de Leon, M., Xu, R., Hou, W., Whitbeck, J. C., Krummenacher, C., Montgomery, R. I., Spear, P. G., Eisenberg, R. J. & Cohen, G. H. ( 1998; ). Monoclonal antibodies to distinct sites on herpes simplex virus (HSV) glycoprotein D block HSV binding to HVEM. Journal of Virology 72, 3595-3601.
    [Google Scholar]
  13. Rodger, G., Boname, J., Bell, S. & Minson, T. ( 2001; ). Assembly and organization of glycoproteins B, C, D, and H in herpes simplex virus type 1 particles lacking individual glycoproteins: no evidence for the formation of a complex of these molecules. Journal of Virology 75, 710-716.[CrossRef]
    [Google Scholar]
  14. Roop, C., Hutchinson, L. & Johnson, D. C. ( 1993; ). A mutant herpes simplex virus type 1 unable to express glycoprotein L cannot enter cells, and its particles lack glycoprotein H. Journal of Virology 67, 2285-2297.
    [Google Scholar]
  15. Schranz, P., Neidhardt, H., Schroder, C. H. & Kaerner, H. C. ( 1989; ). A viable HSV-1 mutant deleted in two nonessential major glycoproteins. Virology 170, 273-276.[CrossRef]
    [Google Scholar]
  16. Shieh, M. T. & Spear, P. G. ( 1994; ). Herpesvirus-induced cell fusion that is dependent on cell surface heparan sulfate or soluble heparin. Journal of Virology 68, 1224-1228.
    [Google Scholar]
  17. Shukla, D., Liu, J., Blaiklock, P., Shworak, N. W., Bai, X., Esko, J. D., Cohen, G. H., Eisenberg, R. J., Rosenberg, R. D. & Spear, P. G. ( 1999; ). A novel role for 3-O-sulfated heparan sulfate in herpes simplex virus 1 entry. Cell 99, 13-22.[CrossRef]
    [Google Scholar]
  18. Spear, P. G. ( 1993; ). Entry of alphaherpesviruses into cells. Seminars in Virology 4, 167-180.[CrossRef]
    [Google Scholar]
  19. Terry-Allison, T., Montgomery, R. I., Whitbeck, J. C., Xu, R., Cohen, G. H., Eisenberg, R. J. & Spear, P. G. ( 1998; ). HveA (herpesvirus entry mediator A), a coreceptor for herpes simplex virus entry, also participates in virus-induced cell fusion. Journal of Virology 72, 5802-5810.
    [Google Scholar]
  20. Turner, A., Bruun, B., Minson, T. & Browne, H. ( 1998; ). Glycoproteins gB, gD, and gHgL of herpes simplex virus type 1 are necessary and sufficient to mediate membrane fusion in a Cos cell transfection system. Journal of Virology 72, 873-875.
    [Google Scholar]
  21. Whitbeck, J. C., Peng, C., Lou, H., Xu, R., Willis, S. H., Ponce de Leon, M., Peng, T., Nicola, A. V., Montgomery, R. I., Warner, M. S., Soulika, A. M., Spruce, L. A., Moore, W. T., Lambris, J. D., Spear, P. G., Cohen, G. H. & Eisenberg, R. J. ( 1997; ). Glycoprotein D of herpes simplex virus (HSV) binds directly to HVEM, a member of the tumor necrosis factor receptor superfamily and a mediator of HSV entry. Journal of Virology 71, 6083-6093.
    [Google Scholar]
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