1887
Preview this article:

There is no abstract available.

Loading

Article metrics loading...

/content/journal/jgv/10.1099/0022-1317-80-7-1557
1999-07-01
2022-08-10
Loading full text...

Full text loading...

/deliver/fulltext/jgv/80/7/0801557a.html?itemId=/content/journal/jgv/10.1099/0022-1317-80-7-1557&mimeType=html&fmt=ahah

References

  1. Alexander L., Du Z., Rosenzweig M., Jung J. U., Desrosiers R. C. 1997; A role for natural simian immunodeficiency virus and human immunodeficiency virus type 1 Nef alleles in lymphocyte activation. Journal of Virology 71:6094–6099
    [Google Scholar]
  2. Almond N. M., Heeney J. L. 1998; AIDS vaccine development in primate models. AIDS 12:S133–S140
    [Google Scholar]
  3. Almond N., Jenkins A., Heath A. B., Kitchin P. 1993; Sequence variation in the env gene of simian immunodeficiency virus recovered from immunized macaques is predominantly in the V1 region. Journal of General Virology 74:865–871
    [Google Scholar]
  4. Baba T. W., Koch J., Mittler E. S., Greene M., Wyand M., Penninck D., Ruprecht R.M. 1994; Mucosal infection of neonatal rhesus monkeys with cell-free SIV. AIDS Research and Human Retroviruses 10:351–357
    [Google Scholar]
  5. Baba T. W., Jeong Y. S., Pennick D., Bronson R., Greene M. F., Ruprecht R.M. 1995; Pathogenicity of live, attenuated SIV after mucosal infection of neonatal macaques. Science 267:1820–1825
    [Google Scholar]
  6. Barber S. A., Flaherty M. T., Plafker S. M., Clements J. E. 1998; A novel kinase activity associated with Nef derived from neurovirulent simian immunodeficiency virus. Virology 251:165–175
    [Google Scholar]
  7. Baskin G. B., Murphey-Corb M., Watson E. A., Martin L. N. 1988; Necropsy findings in rhesus monkeys experimentally infected with cultured simian immunodeficiency virus (SIV)/delta. Veterinary Pathology 25:456–467
    [Google Scholar]
  8. Baur A. S., Sawai E. T., Dazin P., Fantl W. J., Cheng-Mayer C., Peterlin B. M. 1994; HIV-1 Nef leads to inhibition or activation of T cells depending on its intracellular localization. Immunity 1:373–384
    [Google Scholar]
  9. Baur A. S., Sass G., Laffert B., Willbold D., Cheng-Mayer C., Peterlin B. M. 1997; The N-terminus of Nef from HIV-1/SIV associates with a protein complex containing Lck and a serine kinase. Immunity 6:283–291
    [Google Scholar]
  10. Beer B., Scherer J., zur Megede J., Norley S., Baier M., Kurth R. 1996; Lack of dichotomy between virus load of peripheral blood and lymph nodes during long-term simian immunodeficiency virus infection of African green monkeys. Virology 219:367–375
    [Google Scholar]
  11. Beer B., Denner J., Brown C. R., Norley S., zur Megede J., Coulibaly C., Plesker R., Holzammer S., Baier M., Hirsch V. M., Kurth R. 1998; Simian immunodeficiency virus of African green monkeys is apathogenic in the newborn natural host. Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology 18:210–220
    [Google Scholar]
  12. Bell I., Ashman C., Maughan J., Hooker E., Cook F., Reinhart T. A. 1998; Association of simian immunodeficiency virus Nef with the T-cell receptor (TCR) ζ chain leads to TCR down-modulation. Journal of General Virology 79:2717–2727
    [Google Scholar]
  13. Bellas R. E., Hopkins N., Li Y. 1993; The NF-ĸ B binding site is necessary for efficient replication of simian immunodeficiency virus of macaques in primary macrophages but not in T cellsitalic>in vitro. Journal of Virology 67:2908–2913
    [Google Scholar]
  14. Benveniste R. E., Morton W. R., Clark E. A., Tsai C. C., Ochs H. D., Ward J. M., Kuller L., Knott W. B., Hill R. W., Gale M. J. and others 1988; Inoculation of baboons and macaques with simian immunodeficiency virus/Mne, a primate lentivirus closely related to human immunodeficiency virus type 2. Journal of Virology 62:2091–2101
    [Google Scholar]
  15. Bohm R. P. Jr, Martin L. N., Davison-Fairburn B., Baskin G. B., Murphey-Corb M. 1993; Neonatal disease induced by SIV infection of the rhesus monkey (Macaca mulatta) . AIDS Research and Human Retroviruses 9:1131–1137
    [Google Scholar]
  16. Bukovsky A. A., Dorfman T., Weimann A., Gottlinger H. G. 1997; Nef association with human immunodeficiency virus type 1 virions and cleavage by the viral protease. Journal of Virology 71:1013–1018
    [Google Scholar]
  17. Burns D. P., Desrosiers R. C. 1991; Selection of genetic variants of simian immunodeficiency virus in persistently infected rhesus monkeys. Journal of Virology 65:1843–1854
    [Google Scholar]
  18. Chackerian B., Long E. M., Luciw P. A., Overbaugh J. 1997; Human immunodeficiency virus type 1 coreceptors participate in postentry stages in the virus replication cycle and function in simian immunodeficiency virus infection. Journal of Virology 71:3932–3939
    [Google Scholar]
  19. Chen Z., Zhou P., Ho D. D., Landau N. R., Marx P. A. 1997; Genetically divergent strains of simian immunodeficiency virus use CCR5 as a coreceptor for entry. Journal of Virology 71:2705–2714
    [Google Scholar]
  20. Chen Z., Gettie A., Ho D. D., Marx P. A. 1998; Primary SIVsm isolates use the CCR5 coreceptor from sooty Mangabeys naturally infected in West Africa: a comparison of coreceptor usage of primary SIVsm, HIV-2 and SIVmac. Virology 246:113–124
    [Google Scholar]
  21. Collette Y., Dutartre H., Benzirane A., Ramos-Morales F., Benarous F., Harris M., Olive D. 1996; Physical and functional interaction of Nef with Lck. Journal of Biological Chemistry 271:6333–6341
    [Google Scholar]
  22. Collins K. L., Chen B. K., Kalams S. A., Walker B. D., Baltimore D. 1998; HIV-1 Nef protein protects infected primary cells against killing by cytotoxic T lymphocytes. Nature 391:397–401
    [Google Scholar]
  23. Courgnaud V., Saurin W., Villinger F., Sonigo P. 1998; Different evolution of simian immunodeficiency virus in a natural host and a new host. Virology 247:41–50
    [Google Scholar]
  24. De S. K., Marsh J. W. 1994; HIV-1 Nef inhibits a common activation pathway in NIH-3T3 cells. Journal of Biological Chemistry 269:6656–6660
    [Google Scholar]
  25. Deng H., Unutmaz D., KewalRamani V. N., Littman D. R. 1997; Expression cloning of new receptors used by simian and human immunodeficiency viruses. Nature 388:296–300
    [Google Scholar]
  26. Desrosiers R. C. 1990; The simian immunodeficiency viruses. Annual Review of Immunology 8:557–578
    [Google Scholar]
  27. Desrosiers R. C., Wyand M. S., Kodama T., Ringler D. J., Arthur L. O., Sehgal P. K., Letvin N. L., King N. W., Daniel M. D. 1989; Vaccine protection against simian immunodeficiency virus infection. Proceedings of the National Academy of Sciences, USA 86:6353–6357
    [Google Scholar]
  28. Desrosiers R. C., Lifson J. D., Gibbs J. S., Czajak S. C., Howe A. Y., Arthur L. O., Johnson R. P. 1998; Identification of highly attenuated mutants of simian immunodeficiency virus. Journal of Virology 72:1431–1437
    [Google Scholar]
  29. Dewhurst S., Gelbard H. A., Fine S. M. 1996; Neuropathogenesis of AIDS. Molecular Medicine Today 2:16–23
    [Google Scholar]
  30. Dittmer U., Hunsmann G. 1997; Long-term non-progressive human immunodeficiency virus infection: new insights from the simian immunodeficiency virus model. Journal of General Virology 78:979–984
    [Google Scholar]
  31. Du Z., Lang S. M., Sasseville V. G., Lackner A. A., Ilyinskii P. O., Daniel M. D., Jung J. U., Desrosiers R. C. 1995; Identification of a nef allele that causes lymphocyte activation and acute disease in macaque monkeys. Cell 82:665–674
    [Google Scholar]
  32. Du Z., Ilyinskii P. O., Sasseville V. G., Newstein M., Lackner A. A., Desrosiers R. C. 1996; Requirements for lymphocyte activation by unusual strains of simian immunodeficiency virus. Journal of Virology 70:4157–4161
    [Google Scholar]
  33. Edinger A. L., Amedee A., Miller K., Doranz B. J., Endres M., Sharron M., Samson M., Lu Z. H., Clements J. E., Murphey-Corb M., Peiper S. C., Parmentier M., Broder C. C., Doms R. W. 1997a; Differential utilization of CCR5 by macrophage and T cell tropic simian immunodeficiency virus strains. Proceedings of the National Academy of Sciences, USA 94:4005–4010
    [Google Scholar]
  34. Edinger A. L., Mankowski J. L., Doranz B. J., Margulies B. J., Lee B., Rucker J., Sharron M., Hoffman T. L., Berson J. F., Zink M. C., Hirsch V. M., Clements J. E., Doms R. W. 1997b; CD4-independent, CCR5-dependent infection of brain capillary endothelial cells by a neurovirulent simian immunodeficiency virus strain. Proceedings of the National Academy of Sciences, USA 94:14742–14747
    [Google Scholar]
  35. Finkel T. H., Tudor-Williams G., Banda N. K., Cotton M. F., Curiel T., Monks C., Baba T. W., Ruprecht R. M., Kupfer A. 1995; Apoptosis occurs predominantly in bystander cells and not in productively infected cells of HIV- and SIV-infected lymph nodes. Nature Medicine 1:129–134
    [Google Scholar]
  36. Flaherty M. T., Hauer D. A., Mankowski J. L., Zink M. C., Clements J. E. 1997; Molecular and biological characterization of a neurovirulent molecular clone of simian immunodeficiency virus. Journal of Virology 71:5790–5798
    [Google Scholar]
  37. Flaherty M. T., Barber S. A., Clements J. E. 1998; Neurovirulent simian immunodeficiency virus incorporates a Nef-associated kinase activity into virions. AIDS Research and Human Retroviruses 14:163–170
    [Google Scholar]
  38. Fletcher T. M. III, Brichacek B., Sharova N., Newman M. A., Stivahtis G., Sharp P. M., Emerman M., Hahn B. H., Stevenson M. 1996; Nuclear import and cell cycle arrest functions of the HIV-1 Vpr protein are encoded by two separate genes in HIV-2/SIV(SM). EMBO Journal 15:6155–6165
    [Google Scholar]
  39. Foster J. L., Anderson S. J., Frazier A. L., Garcia J. V. 1994; Specific suppression of human CD4 surface expression by Nef from the pathogenic simian immunodeficiency virus SIVmac239open. Virology 201:373–379
    [Google Scholar]
  40. Fultz P. N., Stricker R. B., McClure H. M., Anderson D. C., Switzer W. M., Horaist C. 1990; Humoral response to SIV/SMM infection in macaque and mangabey monkeys. Journal of Acquired Immune Deficiency Syndromes 3:319–329
    [Google Scholar]
  41. Gallimore A., Cranage M., Cook N., Almond N., Bootman J., Rud E., Silvera P., Dennis M., Corcoran T., Stott J., McMichael A., Gotch F. 1995; Early suppression of SIV replication by CD8+ nef-specific cytotoxic T cells in vaccinated macaques. Nature Medicine 1:1167–1173
    [Google Scholar]
  42. Gao F., Bailes E., Robertson D. L., Chen Y., Rodenburg C. M., Michael S. F., Cummins L. B., Arthur L. O., Peeters M., Shaw G. M., Sharp P. M., Hahn B. H. 1999; Origin Pan troglodytes troglodytes . Nature 397:436–440
    [Google Scholar]
  43. Garcia J. V., Miller A. D. 1991; Serine phosphorylation-independent downregulation of cell-surface CD4 by Nef. Nature 350:508–511
    [Google Scholar]
  44. Geretti A. M., Hulskotte E., Osterhaus A. D. M. E. 1998; Cytotoxic T lymphocytes in AIDS pathogenesis: lessons to be learned from the macaque model of simian immunodeficiency virus infection. Journal of General Virology 79:415–421
    [Google Scholar]
  45. Giavedoni L. D., Planelles V., Haigwood N. L., Ahmad S., Kluge J. D., Marthas M. L., Gardner M. B., Luciw P. A., Yilma T. D. 1993; Immune response of rhesus macaques to recombinant simian immunodeficiency virus gp130 does not protect from challenge infection. Journal of Virology 67:577–583
    [Google Scholar]
  46. Gibbs J. S., Lackner A. A., Lang S. M., Simon M. A., Sehgal P. K., Daniel M. D., Desrosiers R. C. 1995; Progression to AIDS in the absence of a gene for vpr or vpx. Journal of Virology 69:2378–2383
    [Google Scholar]
  47. Glamann J., Burton D. R., Parren P. W., Ditzel H. J., Kent K. A., Arnold C., Montefiori D., Hirsch V. M. 1998; Simian immunodeficiency virus (SIV) envelope-specific Fabs with high-level homologous neutralizing activity: recovery from a long-term-nonprogressor SIV-infected macaque. Journal of Virology 72:585–592
    [Google Scholar]
  48. Graziani A., Galimi F., Medico E., Cottone E., Gramaglia D., Boccaccio C., Comoglio P. M. 1996; The HIV-1 nef protein interferes with phosphatidylinositol 3-kinase activation. Journal of Biological Chemistry 271:6590–6593
    [Google Scholar]
  49. Greenberg M. E., Bronson S., Lock M., Neumann G., Pavlakis G. N., Skowronski J. 1997; Co-localization of HIV-1 Nef with the AP-2 adaptor protein complex correlates with Nef-induced CD4 down-regulation. EMBO Journal 16:6964–6976
    [Google Scholar]
  50. Greenberg M. E., Iafrate A. J., Skowronski J. 1998; The SH3 domain-binding surface and an acidic motif in HIV-1 Nef regulate trafficking of class I MHC complexes. EMBO Journal 17:2777–2789
    [Google Scholar]
  51. Greenway A., Azad A., McPhee D. 1995; Human immunodeficiency virus type 1 Nef protein inhibits activation pathways in peripheral blood mononuclear cells and T-cell lines. Journal of Virology 69:1842–1850
    [Google Scholar]
  52. Gummuluru S., Novembre F. J., Lewis M., Gelbard H. A., Dewhurst S. 1996; Apoptosis correlates with immune activation in intestinal lymphoid tissue from macaques. Virology 225:21–32
    [Google Scholar]
  53. Haigwood N. L., Zolla-Pazner S. 1998; Humoral immunity to HIV, SIV, and SHIV. AIDS 12:S121–S132
    [Google Scholar]
  54. Hanna Z., Kay D. G., Rebai N., Guimond A., Jothy S., Jolicoeur P. 1998; Nef harbors a major determinant of pathogenicity for an AIDSlike disease induced by HIV-1 in transgenic mice. Cell 95:163–175
    [Google Scholar]
  55. Harris M. 1996; From negative factor to a critical role in virus pathogenesis: the changing fortunes of Nef. Journal of General Virology 77:2379–2392
    [Google Scholar]
  56. Heise C., Vogel P., Miller C. J., Halsted C. H., Dandekar S. 1993a; Simian immunodeficiency virus infection ofthe gastrointestinal tract of rhesus macaques: functional, pathological, and morphological changes. American Journal of Pathology 142:1759–1771
    [Google Scholar]
  57. Heise C., Vogel P., Miller C. J., Lackner A., Dandekar S. 1993b; Distribution of SIV infection in the gastrointestinal tract of rhesus macaques at early and terminal stages of AIDS. Journal of Medical Primatology 22:187–193
    [Google Scholar]
  58. Hill C. M., Deng H., Unutmaz D., Kewalramani V. N., Bastiani L., Gorny M. K., Zolla-Pazner S., Littman D. R. 1997; Envelope glycoproteins from human immunodeficiency virus types 1 and 2 and simian immunodeficiency virus can use human CCR5 as a coreceptor for viral entry and make direct CD4-dependent interactions with this chemokine receptor. Journal of Virology 71:6296–6304
    [Google Scholar]
  59. Hirsch V. M., Goldstein S., Hynes N. A., Elkins W. R., London W. T., Zack P. M., Montefiori D., Johnson P. R. 1994; Prolonged clinical latency and survival of macaques given a whole inactivated simian immunodeficiency virus vaccine. Journal of Infectious Diseases 170:51–59
    [Google Scholar]
  60. Hirsch V. M., Dapolito G., Johnson P. R., Elkins W. R., London W. T., Montali R. J., Goldstein S., Brown C. 1995; Induction of AIDS by simian immunodeficiency virus from an African green monkey: species-specific variation in pathogenicity correlates with the extent of in vivo replication. Journal of Virology 69:955–967
    [Google Scholar]
  61. Hirsch V. M., Fuerst T. R., Sutter G., Carroll M. W., Yang L. C., Goldstein S., Piatak M. Jr, Elkins W. R., Alvord W. G., Montefiori D. C., Moss B., Lifson J. D. 1996; Patterns of viral replication correlate with outcome in simian immunodeficiency virus (SIV)-infected macaques: effect of prior immunization with a trivalent SIV vaccine in modified vaccinia virus Ankara. Journal of Virology 70:3741–3752
    [Google Scholar]
  62. Hirsch V. M., Sharkey M. E., Brown C. R., Brichacek B., Goldstein S., Wakefield J., Byrum R., Elkins W. R., Hahn B. H., Lifson J. D., Stevenson M. 1998; Vpx is required for dissemination and pathogenesis of SIVsmPBj: evidence of macrophage-dependent viral amplification. Nature Medicine 4:1401–1407
    [Google Scholar]
  63. Hoch J., Lang S. M., Weeger M., Stahl-Hennig C., Coulibaly C., Dittmer U., Hunsmann G., Fuchs D., Muller J., Sopper S. 1995; Vpx deletion mutant of simian immunodeficiency virus induces AIDS in rhesus monkeys. Journal of Virology 69:4807–4813
    [Google Scholar]
  64. Hodge S., Novembre F. J., Whetter L., Gelbard H. A., Dewhurst S. 1998; Induction of Fas ligand expression by an acutely lethal simian immunodeficiency virus, SIVsmmPBj14. Virology 252:354–363
    [Google Scholar]
  65. Howe A. Y. M., Jung J. U., Desrosiers R. C. 1998; Zeta chain of the T-cell receptor interacts with Nef of simian immunodeficiency virus and human immunodeficiency virus type 2. JournalofVirology 72:9827–9834
    [Google Scholar]
  66. Hua J., Cullen B. R. 1997; Human immunodeficiency virus types 1 and 2 and simian immunodeficiency virus Nefuse distinct but overlapping target sites for downregulation of cell surface CD4. Journal of Virology 71:6742–6748
    [Google Scholar]
  67. Iafrate A. J., Bronson S., Skowronski J. 1997; Separable functions of Nef disrupt two aspects of T cell receptor machinery: CD4 expression and CD3 signaling. EMBO Journal 16:673–684
    [Google Scholar]
  68. Ilyinskii P. O., Desrosiers R. C. 1996; Efficient transcription and replication of simian immunodeficiency virus in the absence of NF-ĸ B and Sp1 binding elements. Journal of Virology 70:3118–3126
    [Google Scholar]
  69. Ilyinskii P. O., Simon M. A., Czajak S. C., Lackner A. A., Desrosiers R. C. 1997; Induction of AIDS by simian immunodeficiency virus lacking NF-ĸ B and SP1 binding elements. Journal of Virology 71:1880–1887
    [Google Scholar]
  70. Israel Z. R., Edmonson P. F., Maul D. H., O’Neil S. P., Mossman S. P., Thiriart C., Fabry L., Van Opstal O., Bruck C., Bex F. and others 1994; Incomplete protection, but suppression of virus burden, elicited by subunit simian immunodeficiency virus vaccines. Journal of Virology 68:1843–1853
    [Google Scholar]
  71. Javaherian K., Langlois A. J., Montefiori D. C., Kent K. A., Ryan K. A., Wyman P. D., Stott J., Bolognesi D. P., Murphey-Corb M., Larosa G. J. 1994; Studies of the conformation-dependent neutralizing epitopes of simian immunodeficiency virus envelope protein. Journal of Virology 68:2624–2631
    [Google Scholar]
  72. Joag S. V., Stephens E. B., Galbreath D., Zhu G. W., Li Z., Foresman L., Zhao L. J., Pinson D. M., Narayan O. 1995; Simian immunodeficiency virus SIVmac chimeric virus whose env gene was derived from SIV encephalitic brain is macrophage-tropic but not neurovirulent. Journal of Virology 69:1367–1369
    [Google Scholar]
  73. Johnson R. P. 1996; Macaque models for AIDS vaccine development. Current Opinion in Immunology 8:554–560
    [Google Scholar]
  74. Jolly C., Phillips-Conroy J. E., Turner T. R., Broussard S., Allan J. S. 1996; SIVagm incidence over two decades in a natural population of Ethiopian grivet monkeys (Cercopithecus aethiops aethiops). Journal of Medical Primatology 25:78–83
    [Google Scholar]
  75. Kaur A., Grant R. M., Means R. E., McClure H., Feinberg M., Johnson R. P. 1998; Diverse host responses and outcomes following simian immunodeficiency virus SIVmac239 infection in sooty mangabeys and rhesus macaques. Journal of Virology 72:9597–9611
    [Google Scholar]
  76. Kestler H. W., Ringler D. J., Mori K., Panicali D. L., Sehgal P. K., Daniel M. D., Desrosiers R. C. 1991; Importance ofthe nef gene for maintenance of high virus loads and for development of AIDS. Cell 65:651–662
    [Google Scholar]
  77. Khan I. H., Sawai E. T., Antonio E., Weber C. J., Mandrell C. P., Montbriand P., Luciw P. A. 1998; Role of the SH3-ligand domain of simian immunodeficiency virus Nef in interaction with Nef-associated kinase and simian AIDS in rhesus macaques. Journal of Virology 72:5820–5830
    [Google Scholar]
  78. Kinsey N. E., Anderson M. G., Unangst T. J., Joag S. V., Narayan O., Zink M. C., Clements J. E. 1996; Antigenic variation of SIV: mutations in V4 alter the neutralization profile. Virology 221:14–21
    [Google Scholar]
  79. Kirchhoff F., Pohlmann S., Hamacher M., Means R. E., Kraus T., Uberla K., Di Marzio P. 1997; Simian immunodeficiency virus variants with differential T-cell and macrophage tropism use CCR5 and an unidentified cofactor expressed in CEM x 174 cells for efficient entry. Journal of Virology 71:6509–6516
    [Google Scholar]
  80. Kurth R., Norley S. 1996; Why don’t the natural hosts of SIV develop simian AIDS?. Journal of NIH Research 8:33–37
    [Google Scholar]
  81. Lackner A. A., Smith M. O., Munn R. J., Martfeld D. J., Gardner M. B., Marx P. A., Dandekar S. 1991; Localization of simian immunodeficiency virus in the central nervous system of rhesus monkeys. American Journal of Pathology 139:609–621
    [Google Scholar]
  82. Lamb-Wharton R. J., Joag S. V., Stephens E. B., Narayan O. 1997; Primate models of AIDS vaccine development. AIDS 11:S121–S126
    [Google Scholar]
  83. Lane J. H., Sasseville V. G., Smith M. O., Vogel P., Pauley D. R., Heyes M. P., Lackner A. A. 1996; Neuroinvasion by simian immunodeficiency virus coincides with increased numbers of perivascular macrophages/microglia and intrathecal immune activation. Journal of Neurovirology 2:423–432
    [Google Scholar]
  84. Lang S. M., Weeger M., Stahl-Hennig C., Coulibaly C., Hunsmann G., Muller J., Muller-Hermelink H., Fuchs D., Wachter H., Daniel M. M. 1993; Importance of Vpr for infection of rhesus monkeys with simian immunodeficiency virus. Journal of Virology 67:902–912
    [Google Scholar]
  85. Le Gall S., Erdtmann L., Benichou S., Berlioz-Torrent C., Liu L., Benarous R., Heard J.-M., Schwartz O. 1998; Nef interacts with the μ subunit of clathrin adapter complexes and reveals a cryptic sorting signal in MHC I molecules. Immunity 8:483–495
    [Google Scholar]
  86. Letvin N. L., Daniel M. D., Sehgal P. K., Desrosiers R. C., Hunt R. D., Waldron L. M., MacKey J. J., Schmidt D. K., Chalifoux L. V., King N. W. 1985; Induction of AIDS-like disease in macaque monkeys with T-cell tropic retrovirus STLV-III. Science 230:71–73
    [Google Scholar]
  87. Letvin N. L., Reimann K. A., Yasutomi Y., Ringler D. J., Yamamoto H. 1994; The SIVmac specific cytotoxic T lymphocyte response in the acutely infected rhesus monkey. Current Topics in Microbiology and Immunology 188:175–184
    [Google Scholar]
  88. Lindemann D., Wilhelm R., Renard P., Althage A., Zinkernagel R., Mous J. 1994; Severe immunodeficiency associated with a human immunodeficiency virus 1 NEF/3-long terminal repeat transgene. Journal of Experimental Medicine 179:797–807
    [Google Scholar]
  89. Lohman B. L., McChesney M. B., Miller C. J., McGowan E., Joye S. M., Van Rompay K. K., Reay E., Antipa L., Pedersen N. C., Marthas M. L. 1994; A partially attenuated simian immunodeficiency virus induces host immunity that correlates with resistance to pathogenic virus challenge. Journal of Virology 68:7021–7029
    [Google Scholar]
  90. Lowenstine L. J., Pedersen N. C., Higgins J., Pallis K. C., Uyeda A., Marx P., Lerche N. W., Munn R. J., Gardner M. B. 1986; Seroepidemiologic survey of captive Old World primates for antibodies to human and simian retroviruses, and isolation of a lentivirus from sooty mangabeys (Cercocebus atys). International Journal of Cancer 38:563–574
    [Google Scholar]
  91. Lu X., Yu H., Liu S.-H., Brodsky F. M., Peterlin B. M. 1998; Interactions between HIV-1 Nef and vacuolar ATPase facilitate the internalization of CD4. Immunity 8:647–656
    [Google Scholar]
  92. Luo W., Peterlin B. M. 1997; Activation of the T-cell receptor signaling pathway by Nef from an aggressive strain of simian immunodeficiency virus. Journal of Virology 71:9531–9537
    [Google Scholar]
  93. McChesney M. B., Collins J. R., Lu D., Lu X., Torten J., Ashley R. L., Cloyd M.W., Miller C.J. 1998; Occult systemic infection and persistent simian immunodeficiency virus (SIV)-infected rhesus macaques that were transiently viremic after intravaginal inoculation of SIV. Journal of Virology 72:10029–10035
    [Google Scholar]
  94. Mankowski J. L., Spelman J. P., Ressetar H. G., Strandberg J. D., Laterra J., Carter D. L., Clements J. E., Zink M. C. 1994; Neurovirulent simian immunodeficiency virus replicates productively in endothelial cells of the central nervous system in vivo and in vitro . Journal of Virology 68:8202–8208
    [Google Scholar]
  95. Mankowski J. L., Flaherty M. T., Spelman J. P., Hauer D., Didier P. J., Amedee A. M., Murphey-Corb M., Kirstein L. M., Munoz A., Clements J. E., Zink M. C. 1997; Pathog enesis of simian immunodeficiency virus encephalitis: viral determinants of neurovirulence. Journal of Virology 71:6055–6060
    [Google Scholar]
  96. Manninen A., Hiipakka M., Vihinen M., Lu W., Mayer G. J., Saksela K. 1998; SH3-domain binding function of HIV-1 Nef is required for association with a PAK-related kinase. Virology 250:273–282
    [Google Scholar]
  97. Marcon L., Choe H., Martin K. A., Farzan M., Ponath P. D., Wu L., Newman W., Gerard N., Gerard C., Sodroski J. 1997; Utilization of C–C chemokine receptor 5 by the envelope glycoproteins of a pathogenic simian immunodeficiency virus, SIVmac239. Journal of Virology 71:2522–2527
    [Google Scholar]
  98. Marthas M. L., Sutjipto S., Higgins J., Lohman B., Torten J., Luciw P. A., Marx P. A., Pedersen N. C. 1990; Immunization with a live, attenuated simian immunodeficiency virus (SIV) prevents early disease but not infection in rhesus macaques challenged with pathogenic SIV. Journal of Virology 64:3694–3700
    [Google Scholar]
  99. Marthas M. L., Van Rompay K. K. A., Otsyula M., Miller C. J., Canfield D. R., Pedersen N. C., McChesney M. B. 1995; Viral factors determine progression to AIDS in simian immunodeficiency virus-infected newborn rhesus macaques. Journal of Virology 69:4198–4205
    [Google Scholar]
  100. Martin L., Murphey-Corb M., Mack P., Baskin G. B., Pantaleo G., Vaccarezza M., Fox C. H., Fauci A. S. 1997; Cyclosporin A modulation of early virologic and immunologic events during primary simian immunodeficiency virus infection in rhesus monkeys. Journal of Infectious Diseases 176:374–383
    [Google Scholar]
  101. Marx P. A., Spira A. I., Gettie A., Dailey P. J., Veazey R. S., Lackner A. A., Mahoney C. J., Miller C. J., Claypool L. E., Ho D. D., Alexander N. J. 1996; Progesterone implants enhance SIV vaginal transmission and early virus load. Nature Medicine 10:1084–1089
    [Google Scholar]
  102. Mattapallil J. J., Smit-McBride Z., McChesney M., Dandekar S. 1998; Intestinal intraepithelial lymphocytes are primed for gamma interferon and MIP-1β expression and display antiviral cytotoxic activity despite severe CD4+ T-cell depletion in primary simian immunodeficiency virus infection. Journal of Virology 72:6421–6429
    [Google Scholar]
  103. Miller C. J., Marthas M., Torten J., Alexander N. J., Moore J. P., Doncel G. F., Hendrickx A. G. 1994; Intravaginal inoculation of rhesus macaques with cell-free simian immunodeficiency virus results in persistent or transient viremia. Journal of Virology 68:6391–6400
    [Google Scholar]
  104. Mohri H., Bonhoeffer S., Monard S., Perelson A. S., Ho D. D. 1998; Rapid turnover of T lymphocytes in SIV-infected rhesus macaques. Science 279:1223–1227
    [Google Scholar]
  105. Mortara L., Letourneur F., Gras-Masse H., Venet A., Guillet J. G., Bourgault-Villada I. 1998; Selection of virus variants and emergence of virus escape mutants after immunization with an epitope vaccine. Journal of Virology 72:1403–1410
    [Google Scholar]
  106. Murphey-Corb M., Martin L. N., Rangan S. R., Baskin G. B., Gormus B. J., Wolf R. H., Andes W. A., West M., Montelaro R. C. 1986; Isolation of an HTLV-III-related retrovirus from macaques with simian AIDS and its possible origin in asymptomatic mangabeys. Nature 321:435–437
    [Google Scholar]
  107. Murphey-Corb M., Montelaro R. C., Miller M. A., West M., Martin L. N., Davison-Fairburn B., Ohkawa S., Baskin G. B., Zhang J. Y., Miller G. B. and others 1991; Efficacy ofSIV/deltaB670 glycoprotein-enriched and glycoprotein-depleted subunit vaccines in protecting against infection and disease in rhesus monkeys. AIDS 5:655–662
    [Google Scholar]
  108. Murray E. A., Rausch D. M., Lendvay J., Sharer L. R., Eiden L. E. 1992; Cognitive and motor impairments associated with SIV infection in rhesus monkeys. Science 255:1246–1249
    [Google Scholar]
  109. Neildez O., Le Grand R., Caufour P., Vaslin B., Cheret A., Matheux F., Theodoro F., Roques P., Dormont D. 1998; Selective quasispecies transmission after systemic or mucosal exposure of macaques to simian immunodeficiency virus. Virology 243:12–20
    [Google Scholar]
  110. Nerrienet E., Amouretti X., Muller-Trutwin M. C., Poaty-Mavoungou V., Bedjebaga I., Nguyen H. T., Dubreuil G., Corbet S., Wickings E. J., Barre-Sinoussi F., Georges A. J., Georges-Courbot M. C. 1998; Phylogenetic analysis of SIV and STLV type I in mandrills (Mandrillus sphinx):indications that intracolony transmissions are predominantly the result of male-to-male aggressive contacts. AIDS Research and Human Retroviruses 14:785–796
    [Google Scholar]
  111. Niederman T. M., Garcia J. V., Hastings W. R., Luria S., Ratner L. 1992; Human immunodeficiency virus type 1 Nef protein inhibits NF-ĸ B induction in human T cells. Journal of Virology 66:6213–6219
    [Google Scholar]
  112. Norley S. G., Kraus G., Ennen J., Bonilla J., Konig H., Kurth R. 1990; Immunological studies of the basis for the apathogenicity of simian immunodeficiency virus from African green monkeys. Proceedings of the National Academy of Sciences, USA 87:9067–9071
    [Google Scholar]
  113. Novembre F. J., DeRosayro J., O’Neill S. P., Anderson D. C., Klumpp S. A., McClure H. M. 1998; Isolation and characterization of a neuropathogenic simian immunodeficiency virus derived from a sooty mangabey. Journal of Virology 72:8841–8851
    [Google Scholar]
  114. Ohta Y., Masuda T., Tsujimoto H., Ishikawa K., Kodama T., Morikawa S., Nakai M., Honjo S., Hayami M. 1988; Isolation of simian immunodeficiency virus from African green monkeys and seroepidemiologic survey of the virus in various non-human primates. International Journal of Cancer 41:115–122
    [Google Scholar]
  115. Otsyula M. G., Gettie A., Suleman M., Tarara R., Mohamed I., Marx P. 1995; Apparent lack of vertical transmission of simian immunodeficiency virus (SIV) in naturally infected African green monkeys, Cercopithecus aethiops . Annals of Tropical Medicine and Parasitology 89:573–576
    [Google Scholar]
  116. Overbaugh J., Rudensey L. M., Papenhausen M. D., Benveniste R. E., Morton W. R. 1991; Variation in simian immunodeficiency virus env is confined to V1 and V4 during progression to simian AIDS. Journal of Virology 65:7025–7031
    [Google Scholar]
  117. Park I. W., Sodroski J. 1995; Functional analysis ofthe vpx, vpr, and nef genes of simian immunodeficiency virus. Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology 8:335–344
    [Google Scholar]
  118. Pauza C. D., Horejsh D., Wallace M. 1998; Mucosal transmission of virulent and avirulent lentiviruses in macaques. AIDS Research and Human Retroviruses 14:S83–S87
    [Google Scholar]
  119. Phillips-Conroy J. E., Jolly C. J., Petros B., Allan J. S., Desrosiers R. C. 1994; Sexual transmission of SIVagm in wild grivet monkeys. Journal of Medical Primatology 23:1–7
    [Google Scholar]
  120. Piguet V., Chen Y. L., Mangasarian A., Foti M., Carpentier J. L., Trono D. 1998; Mechanism of Nef-induced CD4 endocytosis: Nef connects CD4 with the μ chain of adaptor complexes. EMBO Journal 17:2472–2481
    [Google Scholar]
  121. Reimann K. A., Tenner-Racz K., Racz P., Montefiori D. C., Yasutomi Y., Lin W., Ransil B. J., Letvin N. L. 1994; Immunopathogenic events in acute infection of rhesus monkeys with simian immunodeficiency virus of macaques. Journal of Virology 68:2362–2370
    [Google Scholar]
  122. Rey-Cuille M., Berthier J.-L., Bomsel-Demontoy M., Chaduc Y., Montagnier L., Hovanessian A. G., Chakrabarti L. A. 1998; Simian immunodeficiency virus replicates to high levels in sooty mangabeys without inducing disease. Journal of Virology 72:3872–3886
    [Google Scholar]
  123. Rosenberg Y. J., White B. D., Papermaster S. F., Zack P., Jarling P. B., Eddy G. A., Burke D. S., Lewis M. G. 1991; lymphocyte activation and susceptibility to SIVPBj-14-induced acute death in macaques. Journal of Medical Primatology 20:206–210
    [Google Scholar]
  124. Rosenberg Y. J., Cafaro A., Brenan T., Greenhouse J. G., Villinger F., Ansari A. A., Brown C., McKinnon K., Bellah S., Yalley-Ogunro J., Elkins W. R., Garner S., Lewis M. G. 1997; Virus-induced cytokines regulate circulating lymphocyte levels during primary SIV infections. International Immunology 9:703–712
    [Google Scholar]
  125. Rosenberg Y. J., Anderson A. O., Pabst R. 1998; HIV-induced decline in blood CD4/CD8 ratios: viral killing or altered lymphocyte trafficking?. Immunology Today 19:10–17
    [Google Scholar]
  126. Rosenzweig M., DeMaria M. A., Harper D. M., Friedrich S., Jain R. K., Johnson R. P. 1998; Increased rates of CD4(+) and CD8(+) T lymphocyte turnover in simian immunodeficiency virus-infected macaques. Proceedings of the National Academy of Sciences, USA 95:6388–6393
    [Google Scholar]
  127. Ruprecht R. M., Baba T. W., Liska V., Ayehunie S., Andersen J., Montefiori D. C., Trichel A., Murphey-Corb M., Martin L., Rizvi T. A., Bernacky B. J., Buchl S. J., Keeling M. 1998; Oral SIV, SHIV and HIV type 1 infection. AIDS Research and Human Retroviruses 14:S97–S102
    [Google Scholar]
  128. Saksela K., Cheng G., Baltimore D. 1995; Proline-rich (PxxP) motifs in HIV-1 Nef bind to SH3 domains of a subset of Src kinases and are required for the enhanced growth of Nef+ viruses but not for down-regulation of CD4. EMBO Journal 14:484–491
    [Google Scholar]
  129. Sasseville V. G., Lane J. H., Walsh D., Ringler D. J., Lackner A. A. 1995; VCAM-1 expression and leukocyte trafficking to the CNS occur early in infection with pathogenic isolates of SIV. Journal of Medical Primatology 24:123–131
    [Google Scholar]
  130. Sasseville V. G., Smith M. M., Mackay C. R., Pauley D. R., Mansfield K. G., Ringler D., Lackner A. A. 1996; Chemokine expression in simian immunodeficiency virus-induced AIDS encephalitis. American Journal of Pathology 149:1459–1467
    [Google Scholar]
  131. Saucier M., Hodge S., Dewhurst S., Gibson T., Gibson J. P., McClure H. M., Novembre F. J. 1998; The tyrosine-17 residue of Nef in SIVsmmPBj14 is required for acute pathogenesis and contributes to replication in macrophages. Virology 244:261–272
    [Google Scholar]
  132. Schenkel A. R., Uno H., Pauza C. D. 1999; Asymptomatic simian immunodeficiency virus infection decreases blood CD4+ T cells by accumulating recirculating lymphocytes in the lymphoid tissues. Journal of Virology 73:601–607
    [Google Scholar]
  133. Schwartz O., Marechal V., Le Gall S., Lemonnier F., Heard J. M. 1996; Endocytosis of major histocompatibility complex class I molecules is induced by the HIV-1 Nef protein. Nature Medicine 2:338–342
    [Google Scholar]
  134. Sharma D. P., Zink M. C., Anderson M., Adams R., Clements J. E., Joag S. V., Narayan O. 1992; Derivation of neurotropic simian immunodeficiency virus from exclusively lymphocytotropic parental virus:pathogenesis of infection in macaques. Journal of Virology 66:3550–3556
    [Google Scholar]
  135. Shibata R., Maldarelli F., Siemon C., Matano T., Parta M., Miller G., Fredrickson T., Martin M. A. 1997; Infection and pathogenicity of chimeric simian-human immunodeficiency viruses in macaques: determinants of high virus loads and CD4 cell killing. Journal of Infectious Diseases 176:362–373
    [Google Scholar]
  136. Sinclair E., Barbosa P., Feinberg M. B. 1997; The Nef gene products of both simian and human immunodeficiency viruses enhance virus infectivity and are functionally interchangeable. Journal of Virology 71:3641–3651
    [Google Scholar]
  137. Skowronski J., Parks D., Mariani R. 1993; Altered T cell activation and development in transgenic mice expressing the HIV-1 nef gene. EMBO Journal 12:703–713
    [Google Scholar]
  138. Smit-McBride Z., Mattapallil J. J., McChesney M., Ferrick D., Dandekar S. 1998; Gastrointestinal T lymphocytes retain high potential for cytokine responses but have severe CD4+ T-cell depletion at all stages of simian immunodeficiency virus infection compared to peripheral lymphocytes. Journal of Virology 72:6646–6655
    [Google Scholar]
  139. Sodora D. L., Gettie A., Miller C. J., Marx P. A. 1998; Vaginal transmission of SIV: assessing infectivity and hormonal influences in macaques inoculated with cell-free and cell-associated viral stocks. AIDS Research and Human Retroviruses 14:S119–S123
    [Google Scholar]
  140. Spira A. I., Marx P. A., Patterson B. K., Mahoney J., Koup R. A., Wolinsky S. M., Ho D. D. 1996; Cellular targets of infection and route of viral dissemination after an intravaginal inoculation of simian immunodeficiency virus into rhesus macaques. Journal of Experimental Medicine 183:215–225
    [Google Scholar]
  141. Stone J. D., Heise C. C., Miller C. J., Halsted C. H., Dandekar S. 1994; Development of malabsorption and nutritional complications in simian immunodeficiency virus-infected rhesus macaques. AIDS 8:1245–1256
    [Google Scholar]
  142. Strelow L. I., Watry D. D., Fox H. S., Nelson J. A. 1998; Efficient infection of brain microvascular endothelial cells by an in vivo-selected neuroinvasive SIVmac variant. Journal of Neurovirology 4:269–280
    [Google Scholar]
  143. Sutjipto S., Pedersen N. C., Miller C. J., Gardner M. B., Hanson C. V., Gettie A., Jennings M., Higgins J., Marx P. A. 1990; Inactivated simian immunodeficiency virus vaccine failed to protect rhesus macaques from intravenous or genital mucosal infection but delayed disease in intravenously exposed animals. Journal of Virology 64:2290–2297
    [Google Scholar]
  144. Ten Haaft P., Verstrepen B., Uberla K., Rosenwirth B., Heeney J. 1998; A pathogenic threshold of virus load defined in simian immunodeficiency virus- or simian-human immunodeficiency virus-infected macaques. Journal of Virology 72:10281–10285
    [Google Scholar]
  145. Trivedi P., Horejsh D., Hinds S. B., Hinds P. W. II, Wu M. S., Salvato M. S., Pauza C. D. 1996; Intrarectal transmission of simian immunodeficiency virus in rhesus macaques: selective amplification and host responses to transient or persistent viremia. Journal of Virology 70:6876–6883
    [Google Scholar]
  146. Veazey R. S., Lackner A. A. 1998; The gastrointestinal tract and the pathogenesis of AIDS. AIDS 12:S35–S42
    [Google Scholar]
  147. Veazey R. S., DeMaria M., Chalivoux L. V., Shevetz D. E., Pauley D. R., Knight H. L., Rosenzweig M., Johnson R. P., Desrosiers R. C., Lackner A. A. 1998; Gastrointestinal tract as a major site of CD4+ T cell depletion and viral replication in SIV infection. Science 280:427–431
    [Google Scholar]
  148. Watson A., Ranchalis J., Travis B., McClure J., Sutton W., Johnson P. R., Hu S.-L., Haigwood N. L. 1997; Plasma viremia in macaques infected with simian immunodeficiency virus: plasma viral load early in infection predicts survival. Journal of Virology 71:284–290
    [Google Scholar]
  149. Weissman D., Rabin R. L., Arthos J., Rubbert A., Dybul M., Swofford R., Venkatesan S., Farber J. M., Fauci A. S. 1997; Macrophage-tropic HIV and SIV envelope proteins induce a signal through the CCR5 chemokine receptor. Nature 389:981–985
    [Google Scholar]
  150. Wykrzykowska J. J., Rosenzweig M., Veazey R. S., Simon M. A., Halvorsen K., Desrosiers R. C., Johnson R. P., Lackner A. A. 1998; Early regeneration of thymic progenitors in rhesus macaques infected with simian immunodeficiency virus. Journal of Experimental Medicine 187:1767–1778
    [Google Scholar]
  151. Xu X. N., Screaton G. R., Gotch F. M., Dong T., Tan R., Almond N., Walker B., Stebbings B., Kent K., Nagata S., Stott J. E., McMichael A. J. 1997; Evasion of cytotoxic T lymphocyte (CTL) responses by Nef-dependent induction of Fas ligand (CD95L) expression on simian immunodeficiency virus-infected cells. Journal of Experimental Medicine 186:7–16
    [Google Scholar]
  152. Yasutomi Y., Reimann K. A., Lord C. I., Miller M. D., Letvin N. L. 1993; Simian immunodeficiency virus-specific CD8+ lymphocyte response in acutely infected rhesus monkeys. Journal of Virology 67:1707–1711
    [Google Scholar]
  153. Yu X. F., Matsuda M., Essex M., Lee T. H. 1990; Open reading frame vpr of simian immunodeficiency virus encodes a virion-associated protein. Journal of Virology 64:5688–5693
    [Google Scholar]
  154. Yu X. F., Yu Q. C., Essex M., Lee T. H. 1991; The vpx gene of simian immunodeficiency virus facilitates efficient viral replication in fresh lymphocytes and macrophage. Journal of Virology 65:5088–5091
    [Google Scholar]
  155. Zink M. C., Amedee A. M., Mankowski J. L., Craig L., Didier P., Carter D. L., Munoz A., Murphey-Corb M., Clements J. E. 1997; Pathogenesis of SIV encephalitis: selection and replication of neurovirulent SIV. American Journal of Pathology 151:793–803
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jgv/10.1099/0022-1317-80-7-1557
Loading
/content/journal/jgv/10.1099/0022-1317-80-7-1557
Loading

Data & Media loading...

Most cited this month Most Cited RSS feed

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error