1887

Abstract

The potential for plasmids encoding a secreted form of bovine herpesvirus type 1 (BHV-1) glycoprotein D (gD) to elicit immune responses in passively immune mice following intramuscular immunization was investigated. In these experiments, 6- to 8-week-old female C3H/HeN or C57BL/6 mice were passively immunized with hyperimmune antisera raised against BHV-1 recombinant, truncated (secreted) gD immediately prior to immunization with plasmids. A single immunization of passively immune mice with plasmid encoding the secreted form of BHV-1 gD resulted in rapid development of both cell-mediated immunity and antibody responses. Furthermore, 50% of mice immunized with a suboptimal dose of recombinant gD formulated into an adjuvant developed significant levels of serum antibodies if mice were pre-treated with hyperimmune antisera. The apparent failure of passive polyclonal antisera to suppress the induction of immune responses to pSLRSV may be related to the immunoglobulin subtypes present in the hyperimmune sera.

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1999-11-01
2019-12-05
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References

  1. Baca-Estrada, M. E. , Snider, M. , Tikoo, S. K. , Harland, R. , Babiuk, L. A. & van Drunen Littel-van den Hurk, S. ( 1996; ). Immunogenicity of bovine herpesvirus-1 glycoprotein D in mice: effect of antigen form on the induction of cellular and humoral immune responses. Viral Immunology 9, 11-22.[CrossRef]
    [Google Scholar]
  2. Bona, C. & Bot, A. ( 1997; ). Neonatal immunoresponsiveness. The Immunologist 5, 5-9.
    [Google Scholar]
  3. Bot, A. , Bot, S. , Garcia-Sastre, A. & Bona, C. ( 1996; ). DNA immunization of newborn mice with a plasmid-expressing nucleoprotein of influenza virus. Viral Immunology 9, 207-210.[CrossRef]
    [Google Scholar]
  4. Carson, D. A. & Raz, E. ( 1997; ). Oligonucleotide adjuvants for T helper 1 (Th1)-specific vaccination. Journal of Experimental Medicine 186, 1621-1622 .[CrossRef]
    [Google Scholar]
  5. Condon, C. , Watkins, S. C. , Celluzzi, C. M. , Thompson, K. & Falo, L. D.Jr ( 1996; ). DNA- based immunization by in vivo transfection of dendritic cells. Nature Medicine 2, 1122-1128.[CrossRef]
    [Google Scholar]
  6. Cox, J. C. & Coulter, A. R. ( 1997; ). Adjuvants: a classification and review of their modes of action. Vaccine 15, 248-256.[CrossRef]
    [Google Scholar]
  7. Czerkinsky, C. , Andersson, G. , Ekre, H. P. , Nilsson, L. A. , Klareskog, L. & Ouchterlony, O. ( 1988; ). Reverse ELISPOT assay for clonal analysis of cytokine production. I. Enumeration of gamma- interferon-secreting cells. Journal of Immunological Methods 110, 29-36.[CrossRef]
    [Google Scholar]
  8. Davis, H. L. , Mancini, M. , Michel, M. L. & Whalen, R. G. ( 1996; ). DNA-mediated immunization to hepatitis B surface antigen: longevity of primary response and effect of boost. Vaccine 14, 910-915.[CrossRef]
    [Google Scholar]
  9. Donnelly, J. J. , Ulmer, J. B. & Liu, M. A. ( 1993; ). Immunization with polynucleotides: a novel approach to vaccination. The Immunologist 2, 20-26.
    [Google Scholar]
  10. Ertl, H. C. J. & Xiang, Z. Q. ( 1996; ). Genetic immunization. Viral Immunology 9, 1-9.[CrossRef]
    [Google Scholar]
  11. Fanger, N. A. , Wardwell, K. , Shen, L. , Tedder, T. F. & Guyre, P. M. ( 1996; ). Type I (CD64) and Type II (CD32) Fc-gamma receptor-mediated phagocytosis by human dendritic cells. Journal of Immunology 157, 541-548.
    [Google Scholar]
  12. Gerloni, M. , Baliou, W. R. , Billetta, R. & Zanetti, M. ( 1997; ). Immunity to Plasmodium falciparum malaria sporozoites by somatic transgene immunization. Nature Biotechnology 15, 876-881.[CrossRef]
    [Google Scholar]
  13. Harte, P. G. , Cooke, A. & Playfair, J. H. ( 1983; ). Specific monoclonal IgM is a potent adjuvant in murine malaria vaccination. Nature 302, 256-258.[CrossRef]
    [Google Scholar]
  14. Hassett, D. E. & Whitton, J. L. ( 1996; ). DNA immunization. Trends in Microbiology 4, 307-312.[CrossRef]
    [Google Scholar]
  15. Hassett, D. E. , Zhang, J. & Whitton, J. L. ( 1997; ). Neonatal DNA immunization with a plasmid encoding an internal viral protein is effective in the presence of maternal antibodies and protects against subsequent viral challenge. Journal of Virology 71, 7881-7888 .
    [Google Scholar]
  16. Henry, C. & Jerne, N. K. ( 1968; ). Competition of 19S and 7S antigen receptors in the primary immune response. Journal of Experimental Medicine 128, 133-152.[CrossRef]
    [Google Scholar]
  17. Heyman, B. , Pilstrom, L. & Shulman, M. J. ( 1988; ). Complement activation is required for IgM-mediated enhancement of the antibody response. Journal of Experimental Medicine 167, 1999-2004 .[CrossRef]
    [Google Scholar]
  18. Hughes, G. , Babiuk, L. A. & van Drunen Littel-van den Hurk, S. ( 1988; ). Functional and topographical analysis of epitopes on bovine herpesvirus type 1 glycoprotein IV. Archives of Virology 103, 47-60.[CrossRef]
    [Google Scholar]
  19. Ishizaka, S. T. , Piacente, P. , Silva, J. & Mishkin, E. M. ( 1995; ). IgG subtype is correlated with efficiency of passive protection and effector function of anti-herpes simplex virus glycoprotein D monoclonal antibodies. Journal of Infectious Diseases 172, 1108-1111 .[CrossRef]
    [Google Scholar]
  20. Julia, V. , Rassoulzadegan, M. & Glaichenhaus, N. ( 1996; ). Resistance to Leishmania major induced by tolerance to a single antigen. Science 274, 421-423.[CrossRef]
    [Google Scholar]
  21. Keller, M. A. , Palmer, C. J. , Jelonek, M. T. , Song, C. H. , Miller, A. , Sercarz, E. E. , Calandra, G. B. & Brust, J. L. ( 1991; ). Modulation of the immune response by maternal antibody. In Immunology of Milk and the Neonate, pp. 207-213. Edited by J. Mestecky. New York: Plenum.
  22. Klaus, G. G. B. , Pepys, M. B. , Kitajima, K. & Askonas, B. A. ( 1979; ). Activation of mouse complement by different classes of mouse antibody. Immunology 38, 687-695.
    [Google Scholar]
  23. Lewis, P. J. , Cox, G. J , van Drunen Littel-van den Hurk, S. & Babiuk, L. A. ( 1997; ). Polynucleotide vaccines in animals: Enhancing and modulating responses. Vaccine 15, 861-864.[CrossRef]
    [Google Scholar]
  24. MacDonald, L. J. ( 1992; ). Factors that can undermine the success of routine vaccination protocols. Veterinary Medicine 87, 223-230.
    [Google Scholar]
  25. Manickan, E. , Kanangat, S. , Rouse, R. J. , Yu, Z. & Rouse, B. T. ( 1997; ). Enhancement of immune response to naked DNA vaccine by immunization with transfected dendritic cells. Journal of Leukocyte Biology 61, 125-132.
    [Google Scholar]
  26. Monteil, M. , Le Potier, M. F. , Guillotin, J. , Cariolet, R. , Houdayer, C. & Eloit, M. ( 1996; ). Genetic immunization of seronegative one-day-old piglets against pseudorabies induces neutralizing antibodies but not protection and is ineffective in piglets from immune dams. Veterinary Research 27, 443-452.
    [Google Scholar]
  27. Mor, G. , Yamshchikov, G. , Sedegah, M. , Takeno, M. , Wang, R. , Houghten, R. A. , Hoffman, S. & Klinman, D. M. ( 1996; ). Induction of neonatal tolerance by plasmid DNA vaccination of mice. Journal of Clinical Investigation 98, 2700-2705 .[CrossRef]
    [Google Scholar]
  28. Pertmer, T. M. , Roberts, T. R. & Haynes, J. R. ( 1996; ). Influenza virus nucleoprotein-specific immunoglobulin G subclass and cytokine responses elicited by DNA vaccination are dependent on the route of vector DNA delivery. Journal of Virology 70, 6119-6125 .
    [Google Scholar]
  29. Phillips, N. E. & Parker, D. C. ( 1983; ). Fc-dependent inhibition of mouse B cell activation by whole anti-mu antibodies. Journal of Immunology 130, 602-606.
    [Google Scholar]
  30. Pisetsky, D. S. ( 1996; ). Immune activation by bacterial DNA: a new genetic code. Immunity 5, 303-310.[CrossRef]
    [Google Scholar]
  31. Ravetch, J. V. ( 1997; ). Fc Receptors. Current Opinions in Immunology 9, 121-125.[CrossRef]
    [Google Scholar]
  32. Ravetch, J. V. & Kinet, J. P. ( 1991; ). Fc Receptors. Annual Review of Immunology 9, 457-492.[CrossRef]
    [Google Scholar]
  33. Reitan, S. K. & Hannestad, K. ( 1995; ). A syngeneic idiotype is immunogenic when borne by IgM but tolerogenic when joined to IgG. European Journal of Immunology 25, 1601-1608 .[CrossRef]
    [Google Scholar]
  34. Ridge, J. P. , Fuchs, E. J. & Matzinger, P. ( 1996; ). Neonatal tolerance revisited: turning on newborn T cells with dendritic cells. Science 271, 1723-1726 .[CrossRef]
    [Google Scholar]
  35. Roman, M. , Martin-Orozco, E. , Goodman, J. S. , Nguyen, M. D. , Sato, Y. , Ronaghy, A. , Kornbluth, R. S. , Richman, D. D. , Carson, D. A. & Raz, E. ( 1997; ). Immunostimulatory DNA sequences function as T helper-1-promoting adjuvants. Nature Medicine 38, 849-854.
    [Google Scholar]
  36. Sarzotti, M. , Robbins, D. S. & Hoffman, P. M. ( 1996; ). Induction of protective CTL responses in newborn mice by a murine retrovirus. Science 271, 1726-1728 .[CrossRef]
    [Google Scholar]
  37. Shulman, M. J. , Pennell, N. , Collins, C. & Hozumi, N. ( 1986; ). Activation of complement by immunoglobulin M is impaired by the substitution serine- 406–asparagine in the immunoglobulin mu heavy chain. Proceedings of the National Academy of Sciences, USA 83, 7678-7682 .[CrossRef]
    [Google Scholar]
  38. Siegrist, C. A. , Barrios, C. , Martinez, X. , Brandt, C. , Berney, M. , Cordova, M. , Kovarik, J. & Lambert, P. H. ( 1998; ). Influence of maternal antibodies on vaccine responses: inhibition of antibody but not T cell responses allows successful early prime-boost strategies in mice. European Journal of Immunology 28, 4138-48.[CrossRef]
    [Google Scholar]
  39. Spalding, D. M. , Koopman, W. J. , Eldridge, J. H. , McGhee, J. R. & Steinman, R. M. ( 1983; ). Accessory cells in murine Peyer‘s patches. Journal of Experimental Medicine 157, 1646-1659 .[CrossRef]
    [Google Scholar]
  40. Steinman, R. M. , Pack, M. & Inaba, K. ( 1997; ). Dendritic cells in the T-cell areas of lymphoid organs. Immunology Reviews 156, 25-37.[CrossRef]
    [Google Scholar]
  41. Tang, D.-C. , DeVit, M. & Johnston, S. A. ( 1992; ). Genetic immunization is a simple method for eliciting an immune response. Nature 356, 152-154.[CrossRef]
    [Google Scholar]
  42. Tew, J. G. , Wu, J. , Qin, D. , Helm, S. , Burton, G. F. & Szakal, A. K. ( 1997; ). Follicular dendritic cells and presentation of antigen and co-stimulatory signals to B cells. Immunology Reviews 156, 39-52.[CrossRef]
    [Google Scholar]
  43. Tikoo, S. K. , Fitzpatrick, D. R. , Babiuk, L. A. & Zamb, T. J. ( 1990; ). Molecular cloning, sequencing, and expression of functional bovine herpesvirus-1 glycoprotein gIV in transfected bovine cells. Journal of Virology 64, 5132-5142 .
    [Google Scholar]
  44. Tikoo, S. K. , Zamb, T. J. & Babiuk, L. A. ( 1993; ). Analysis of bovine herpesvirus 1 glycoprotein gIV truncations and deletions expressed by recombinant vaccinia viruses. Journal of Virology 67, 2103-2109 .
    [Google Scholar]
  45. Ulmer, J. B. , Sadoff, J. C. & Liu, M. A. ( 1996; ). DNA vaccines. Current Opinions in Immunology 8, 531-536.[CrossRef]
    [Google Scholar]
  46. Van de Winkel, J. G. & Capel, P. J. A. ( 1993; ). Human IgG Fc receptor heterogeneity: molecular aspects and clinical implications. Immunology Today 14, 215-221.[CrossRef]
    [Google Scholar]
  47. van Drunen Littel-van den Hurk, S. , van den Hurk, J. V. , Gilchrist, J. E. , Misra, V. & Babiuk, L. A. ( 1984; ). Interactions of monoclonal antibodies and bovine herpesvirus type 1 (BHV-1) glycoproteins: characterization of their biochemical and immunological properties. Virology 135, 466-479.[CrossRef]
    [Google Scholar]
  48. Vieira, P. & Rajewsky, K. ( 1988; ). The half-lives of serum immunoglobulins in adult mice. European Journal of Immunology 18, 313-316.[CrossRef]
    [Google Scholar]
  49. Wang, Y. , Xiang, Z. , Pasquini, S. & Ertl, H. C. ( 1997; ). Immune response to neonatal genetic immunization. Virology 228, 278-284.[CrossRef]
    [Google Scholar]
  50. Wolff, J. A. , Ludtke, J. J. , Acsadi, G. , Williams, P. & Jani, A. ( 1992; ). Long-term persistence of plasmid DNA and foreign gene expression in mouse muscle. Human Molecular Genetics 1, 363-369.[CrossRef]
    [Google Scholar]
  51. Xiang, Z. Q. & Ertl, H. C. J. ( 1992; ). Transfer of maternal antibodies results in inhibition of specific immune responses in the offspring. Virus Research 24, 297-314.[CrossRef]
    [Google Scholar]
  52. Zinkernagel, R. M. ( 1996; ). Immunology taught by viruses. Science 271, 173-178.[CrossRef]
    [Google Scholar]
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